Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Jae Hwan Kwak"'
Publikováno v:
Journal of Analytical Science and Technology, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Objectives Carbon-14 (14C) labeling is a standard technology for tracing molecules and providing their pharmacokinetic profiles. However, its primary focus has been on small molecules, with limited application to biomacromolecules. Particula
Externí odkaz:
https://doaj.org/article/0393b4f6cdc644e29c065204b171a84b
Autor:
Kwanghee Lee, Young-Ah Kim, Chanhyun Jung, Jaeuk Sim, Shanmugam Rajasekar, Jae-Hwan Kwak, Mayavan Viji, Jae-Kyung Jung
Publikováno v:
Molecules, Vol 29, Iss 4, p 894 (2024)
A catalyst-free, additive-free, and eco-friendly method for synthesizing 1,2,4-triazolo[1,5-a]pyridines under microwave conditions has been established. This tandem reaction involves the use of enaminonitriles and benzohydrazides, a transamidation me
Externí odkaz:
https://doaj.org/article/91a326ad95c64ba6aee67a5ce24c812c
Autor:
Young Jin Jung, Narges Hosseininasab, Jungjin Park, Soonsil Hyun, Jae-Kyung Jung, Jae-Hwan Kwak
Publikováno v:
Molecules, Vol 29, Iss 2, p 416 (2024)
A growing global health concern is metabolic syndrome, which is defined by low HDL, diabetes, hypertension, and abdominal obesity. Nuclear receptors are attractive targets for treatment of diseases associated with metabolic syndrome. Liver X receptor
Externí odkaz:
https://doaj.org/article/3d7cc8abbaf0430dbf0de0f3c43f8a43
Autor:
Ahyoung Jo, Jae-Hwan Kwak, Soo-Yeon Woo, Bo-Young Kim, Yonghae Son, Hee-Seon Choi, Jayoung Kim, Munju Kwon, Hyok-Rae Cho, Seong-Kug Eo, Ji Ho Nam, Hyung-Sik Kim, Ninib Baryawno, Dongjun Lee, Koanhoi Kim
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Several derivatives derived from the oxime structure have been reported as potential anticancer agents in various cancers. Here, we first tested a novel oxime-containing derivative of 2-((2,4,5-trifluorobenzyl)oxy)benzaldehyde oxime (TFOBO)
Externí odkaz:
https://doaj.org/article/1e452fcf232c4348a1c81f6e13967c4c
Autor:
Sou Hyun Kim, Doyoung Kwon, Seung Won Son, Tae Bin Jeong, Seunghyun Lee, Jae-Hwan Kwak, Joon-Yong Cho, Dae Youn Hwang, Min-Soo Seo, Kil Soo Kim, Young-Suk Jung
Publikováno v:
Laboratory Animal Research, Vol 37, Iss 1, Pp 1-7 (2021)
Abstract Background Inflammatory bowel disease (IBD), including both Crohn’s disease and ulcerative colitis, are chronic human diseases that are challenging to cure and are often unable to be resolved. The inbred mouse strain C57BL/6 N has been use
Externí odkaz:
https://doaj.org/article/019083237d7e4bd0b96e01a2c2624e53
Publikováno v:
ACS Omega, Vol 5, Iss 36, Pp 22951-22957 (2020)
Externí odkaz:
https://doaj.org/article/77d4bd131cb04c57a11290857540b919
Publikováno v:
Molecules, Vol 28, Iss 3, p 1476 (2023)
Liver metabolic disorders and oxidative stress are crucial factors in the development of nonalcoholic fatty liver disease (NAFLD); however, treatment strategies to combat NAFLD remain poorly established, presenting an important challenge that needs t
Externí odkaz:
https://doaj.org/article/46b93d8b8d91423e9ad6d58aea9c3457
Autor:
Tae Bin Jeong, Joung-Hee Kim, Sou Hyun Kim, Seunghyun Lee, Seung Won Son, Yong Lim, Joon-Yong Cho, Dae Youn Hwang, Kil Soo Kim, Jae-Hwan Kwak, Young-Suk Jung
Publikováno v:
Laboratory Animal Research, Vol 35, Iss 1, Pp 1-7 (2019)
Abstract Acetaminophen (APAP) is the most common antipyretic analgesic worldwide. However, APAP overdose causes severe liver injury, especially centrilobular necrosis, in humans and experimental animals. At therapeutic dosage, APAP is mainly metaboli
Externí odkaz:
https://doaj.org/article/d891be9b173e450787fd178656a36c20
Autor:
Seunghyun Lee, Jae-Hwan Kwak, Sou Hyun Kim, Tae Bin Jeong, Seung Won Son, Joung-Hee Kim, Yong Lim, Joon-Yong Cho, Dae Youn Hwang, Kil Soo Kim, Young-Suk Jung
Publikováno v:
Laboratory Animal Research, Vol 35, Iss 1, Pp 1-7 (2019)
Abstract Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease worldwide. It is characterized by the accumulation of lipids without alcohol intake and often progresses to non-alcoholic steatohepatitis (NASH), liver f
Externí odkaz:
https://doaj.org/article/b71bb1407e4a4e57af31eb02a4f8f23f
Autor:
Seunghyun Lee, Jae-Hwan Kwak, Sou Hyun Kim, Jieun Yun, Joon-Yong Cho, Kilsoo Kim, Daeyeon Hwang, Young-Suk Jung
Publikováno v:
Laboratory Animal Research, Vol 34, Iss 4, Pp 232-238 (2018)
Abstract Animal models have been used to elucidate the pathophysiology of varying diseases and to provide insight into potential targets for therapeutic intervention. Although alternatives to animal testing have been proposed to help overcome potenti
Externí odkaz:
https://doaj.org/article/225e53b9f7a249c39b3d76dc3329a400