Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Jae Hung Shieh"'
Autor:
Ashish Saxena, Matthew S. Walters, Jae-Hung Shieh, Ling-Bo Shen, Kazunori Gomi, Robert J. Downey, Ronald G. Crystal, Malcolm A. S. Moore
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The human airway epithelium lining the bronchial tree contains basal cells that proliferate, differentiate, and communicate with other components of their microenvironment. One method that cells use for intercellular communication involves t
Externí odkaz:
https://doaj.org/article/92449e126f694f7d8e77c16977597922
Autor:
Robert J. Downey, Malcolm A.S. Moore, Ronald G. Crystal, Kazunori Gomi, Matthew S. Walters, Jae-Hung Shieh, Ling-Bo Shen, Ashish Saxena
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
The human airway epithelium lining the bronchial tree contains basal cells that proliferate, differentiate, and communicate with other components of their microenvironment. One method that cells use for intercellular communication involves the secret
Autor:
Jing Mei Hsu, Eric von Hofe, Yen-Michael Hsu, Jae-Hung Shieh, Ok-Kyong Chaekal, Danielle Guarneri, Thomas J. Fahey, Jana Ivanidze, Janusz Puc, Karrie Du, Ashlee You, Theresa Scognamiglio, Ljiljana Vasovic, Melissa Cushing, Moonsoo Jin, Koen Van Besien
Publikováno v:
Journal of Clinical Oncology. 40:6093-6093
6093 Background: ICAM-1 is a cell surface glycoprotein that is typically expressed on endothelial cells and immune cells and a ligand for LFA-1 integrin. It is also overexpressed in several malignancies, in particular anaplastic and advanced thyroid
Autor:
Malcolm A.S. Moore, Jae-Hung Shieh, Marcel R.M. van den Brink, Lauren Young, Wen Zhang, Ivo D. Shterev, Nancy R. Manley, Shiyun Xiao, Gregory D. Sempowski
Publikováno v:
The Journal of Immunology. 199:2701-2712
Total body irradiation (TBI) damages hematopoietic cells in the bone marrow and thymus; however, the long-term effects of irradiation with aging remain unclear. In this study, we found that the impact of radiation on thymopoiesis in mice varied by se
Autor:
Elissa W.P. Wong, Ashish Saxena, Tsann-Long Su, Anisha Chaudhry, Benet Pera, Srikanth R. Ambati, Malcolm A.S. Moore, Jae-Hung Shieh, Eloisi Caldas Lopes
Publikováno v:
Oncotarget
DNA damaging agents cause rapid shrinkage of tumors and form the basis of chemotherapy for sarcomas despite significant toxicities. Drugs having superior efficacy and wider therapeutic windows are needed to improve patient outcomes. We used cell prol
Autor:
Ying Liu, Yang Lin, Jae-Hung Shieh, Chaitanya R. Badwe, Shahin Rafii, Sean Houghton, Fuqiang Geng, Jesus M. Gomez-Salinero, Peipei Guo, Tomer Itkin, Yen-Michael S. Hsu, David Redmond, Brandon Hadland
Publikováno v:
Blood. 134:725-725
During adulthood and embryogenesis, fate decisions of hematopoietic stem and progenitor cells (HSPCs), such as specification, self-renewal, and differentiation are tightly regulated by their neighboring niche cells. Moreover, distinct types of niches
Akademický článek
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Autor:
Jennifer Tsai, Koichi Takahashi, Alan M. Hanash, Marcel R.M. van den Brink, Malcolm A.S. Moore, Amanda M. Holland, Arnab Ghosh, Mallory L. West, Jae-Hung Shieh, Odette M. Smith, Enrico Velardi, Jarrod A Dudakov, Hien Tran, Yusuke Shono, Natalie V. Singer, Lauren Florence Young
Publikováno v:
Nature Cell Biology. 15:309-316
Coordinating the balance between haematopoietic stem cell (HSC) quiescence and self-renewal is crucial for maintaining haematopoiesis lifelong. Equally important for haematopoietic function is modulating HSC localization within the bone marrow niches
Autor:
Marcel R.M. van den Brink, Yoshiko Kubo, Kei Nakachi, Waka Ohishi, Yoichiro Kusunoki, Jae-Hung Shieh, Malcolm A.S. Moore, Munechika Misumi, Kengo Yoshida, Seishi Kyoizumi, Tomonori Hayashi, Lauren F. Young, Junko Kajimura, Kazue Imai, Nan-ping Weng
Accumulated DNA damage in hematopoietic stem cells is a primary mechanism of aging-associated dysfunction in human hematopoiesis. About 70 years ago, atomic-bomb (A-bomb) radiation induced DNA damage and functional decreases in the hematopoietic syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c7f261a7bf6bd8b9e079417cdc00c5
https://europepmc.org/articles/PMC5152679/
https://europepmc.org/articles/PMC5152679/
Autor:
Yoichiro Kusunoki, Malcolm A.S. Moore, Lauren F. Young, Kengo Yoshida, Munechika Misumi, Junko Kajimura, Tomonori Hayashi, Kazue Imai, Seishi Kyoizumi, Waka Ohishi, Jae-Hung Shieh, Marcel R.M. van den Brink, Yoshiko Kubo, Kei Nakachi
It is not yet known whether hematopoietic stem and progenitor cells (HSPCs) are compromised in the aging population of atomic bomb (A-bomb) survivors after their exposure nearly 70 years ago. To address this, we evaluated age- and radiation-related c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b24d7371544ac269612a90b16d8e0839
https://europepmc.org/articles/PMC5015444/
https://europepmc.org/articles/PMC5015444/