Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jae H Hur"'
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50644 (2012)
Defects in mitochondrial electron transport chain (ETC) function have been implicated in a number of neurodegenerative disorders, cancer, and aging. Mitochondrial complex I (NADH dehydrogenase) is the largest and most complicated enzyme of the ETC wi
Externí odkaz:
https://doaj.org/article/768081d1f76244619d58fdbe3ff485d6
Autor:
Karine Van Doninck, Morgan L Mandigo, Jae H Hur, Peter Wang, Julien Guglielmini, Michel C Milinkovitch, William S Lane, Matthew Meselson
Publikováno v:
PLoS Genetics, Vol 5, Iss 3, p e1000401 (2009)
Rotifers of Class Bdelloidea are remarkable in having evolved for millions of years, apparently without males and meiosis. In addition, they are unusually resistant to desiccation and ionizing radiation and are able to repair hundreds of radiation-in
Externí odkaz:
https://doaj.org/article/af5584df8d74402285d334de16c418b4
Autor:
Nga N. Nguyen, Justin Tai, Rhiannon Moore, Camille Goldman, Jingyi Shen, Jae H. Hur, David W. Walker, Yongchan Hong, Anil Rana
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
The β5 subunit of the proteasome has been shown in worms and in human cell lines to be regulatory. In these models, β5 overexpression results in upregulation of the entire proteasome complex which is sufficient to increase proteotoxic stress resist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58704b5da89b8448611e091da4845551
https://doi.org/10.1038/s41598-019-39508-4
https://doi.org/10.1038/s41598-019-39508-4
Publikováno v:
Current biology : CB. 26(16)
In their study of genetic exchange in the bdelloid rotifer Adineta vaga, Debortoli et al. [1] conclude that the patchwork pattern of allele sharing among three individuals in the genomic regions they examined is "…unlikely to arise in cases of PTH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d13cf3c2521c74ddc722f7615f76e7
https://pubmed.ncbi.nlm.nih.gov/27554651
https://pubmed.ncbi.nlm.nih.gov/27554651
Autor:
Matthew Ulgherait, D. Leanne Jones, Michael Rera, Sepehr Bahadorani, Christopher L. Koehler, Jaehyoung Cho, Thomas Lo, Jae H. Hur, William S. Ansari, David W. Walker
Publikováno v:
Cell Metabolism
Cell Metabolism, Elsevier, 2011, 14 (5), pp.623-634. ⟨10.1016/j.cmet.2011.09.013⟩
Cell Metabolism, Elsevier, 2011, 14 (5), pp.623-634. ⟨10.1016/j.cmet.2011.09.013⟩
SummaryIn mammals, the PGC-1 transcriptional coactivators are key regulators of energy metabolism, including mitochondrial biogenesis and respiration, which have been implicated in numerous pathogenic conditions, including neurodegeneration and cardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bd2faf14a17359f3b0cd7e5e6d9f7f5
https://doi.org/10.1016/j.cmet.2011.09.013
https://doi.org/10.1016/j.cmet.2011.09.013
Publikováno v:
Aging (Albany NY)
A major goal of aging research is to identify interventions that prolong lifespan in distantly related organisms. In recent years, genetic studies in both nematodes and rodents have reported that moderate inactivation of genes important for mitochond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c1b03766cf25454c4e423159a0ca50
http://europepmc.org/articles/PMC2837206
http://europepmc.org/articles/PMC2837206
Autor:
Hyun Jong Lee, Jong J. Park, Won Gun Koh, Unyong Jeong, Ji H. Choi, Jae H. Hur, Sung W. Lee, Jeong Ho Cho, J.M. Myoung
Publikováno v:
Nano Letters. 10:347-351
High-performance organic field-effect transistors (OFETs) based on polyelectrolyte gate dielectric and electrospun poly(3-hexylthiophene) (P3HT) nanofibers were fabricated on a flexible polymer substrate. The use of UV-crosslinked hydrogel including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a706ece06581e9f3b7d54f9ab590bdf8
https://doi.org/10.1021/nl903722z
https://doi.org/10.1021/nl903722z
Rotifers of Class Bdelloidea are common freshwater invertebrates of ancient origin whose apparent asexuality has posed a challenge to the view that sexual reproduction is essential for long-term evolutionary success in eukaryotes and to hypotheses fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::357f80d7a99bc24667dd2a661700fe65
https://europepmc.org/articles/PMC4492381/
https://europepmc.org/articles/PMC4492381/
Publikováno v:
Journal of bioenergetics and biomembranes, vol 46, iss 4
The role of mitochondrial complex I in aging has been studied in both C. elegans and Drosophila, where RNAi knock down of specific complex I subunits has been shown to extend lifespan. More recently, studies in Drosophila have shown that an increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca49ea13ee97e33ae6017075a99d6cb
https://escholarship.org/uc/item/374252n9
https://escholarship.org/uc/item/374252n9
Autor:
David W. Walker, Jae H. Hur
Publikováno v:
Aging (Albany NY)
Truncated and mutant forms ofp53 affect life span in Drosophila, nematodes and mice, however the role of wild-type p53 in aging remains unclear. Here conditional over-expression of both wild-type and mutant p53 transgenes indicated that, in adult fli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bcc66306d0957b56f697d308fc0175d
https://doi.org/10.18632/aging.100101
https://doi.org/10.18632/aging.100101