Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Jae H, Chang"'
Autor:
Girish Bankar, Samuel J. Goodchild, Sarah Howard, Karen Nelkenbrecher, Matthew Waldbrook, Michelle Dourado, Noah G. Shuart, Sophia Lin, Clint Young, Zhiwei Xie, Kuldip Khakh, Elaine Chang, Luis E. Sojo, Andrea Lindgren, Sultan Chowdhury, Shannon Decker, Michael Grimwood, Jean-Christophe Andrez, Christoph M. Dehnhardt, Jodie Pang, Jae H. Chang, Brian S. Safina, Daniel P. Sutherlin, James P. Johnson, Jr., David H. Hackos, C. Lee Robinette, Charles J. Cohen
Publikováno v:
Cell Reports, Vol 24, Iss 12, Pp 3133-3145 (2018)
Summary: Selective block of NaV1.7 promises to produce non-narcotic analgesic activity without motor or cognitive impairment. Several NaV1.7-selective blockers have been reported, but efficacy in animal pain models required high multiples of the IC50
Externí odkaz:
https://doaj.org/article/751235f9fe504fde8c6781b6215d87d8
Autor:
Robert S. Jones, Christian Leung, Jae H. Chang, Suzanne Brown, Ning Liu, Zhengyin Yan, Jane R. Kenny, Fabio Broccatelli
Publikováno v:
Drug Metabolism and Disposition. 50:1053-1063
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f8f34f9a3345bb178e5627e887b014c
https://doi.org/10.1124/dmd.121.000784
https://doi.org/10.1124/dmd.121.000784
Publikováno v:
The Saudi Journal of Gastroenterology, Vol 21, Iss 1, Pp 18-24 (2015)
Background/Aims: The double-guidewire technique (DGT) and transpancreatic precut sphincterotomy (TPS) are introduced as alternative biliary cannulation techniques for difficult biliary cannulation. This study aimed to evaluate the sequential use of D
Externí odkaz:
https://doaj.org/article/4b454c3ae9d0435e80d09912a2989337
Autor:
Sultan Chowdhury, Christoph Martin Dehnhardt, Tao Sheng, Clint Young, Rainbow Kwan, Michael Scott Wilson, Jun Chen, Matthew Waldbrook, Dinah Misner, C. Lee Robinette, Rebecca M. Reese, Elaine Chang, Henry Verschoof, Tanja S. Zabka, Girish Bankar, Philippe Bergeron, Luis Sojo, Karen Nelkenbrecher, Daniel P. Sutherlin, Amy Kim, Ivan William Hemeon, Andrea Lindgren, Jae H. Chang, Alla Yurevna Zenova, Shaoyi Sun, Jonathan Maher, Shannon D. Shields, Jun Li, Daniel F. Ortwine, David H. Hackos, Zhiwei Xie, Thilo Focken, Charles J. Cohen, Richard T. Dean, Shannon Decker, Janette Mezeyova, Kuldip Khakh, Antonio G. DiPasquale, Chien-An Chen, Andrew D. White, Brian Safina, Jodie Pang, Qi Jia, Sophia Lin, Jean-Christophe Andrez, J. P. Johnson, Steven J. McKerrall
Publikováno v:
Journal of Medicinal Chemistry. 64:2953-2966
Nav1.7 is an extensively investigated target for pain with a strong genetic link in humans, yet in spite of this effort, it remains challenging to identify efficacious, selective, and safe inhibitors. Here, we disclose the discovery and preclinical p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a8a9431d81bf8ca2eed0fbbfbb36905
https://doi.org/10.1021/acs.jmedchem.1c00049
https://doi.org/10.1021/acs.jmedchem.1c00049
Autor:
Robert S, Jones, Christian, Leung, Jae H, Chang, Suzanne, Brown, Ning, Liu, Zhengyin, Yan, Jane R, Kenny, Fabio, Broccatelli
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals.
The utilization of in vitro data to predict drug pharmacokinetics (PK) in vivo has been a consistent practice in early drug discovery for decades. However, its success is hampered by mispredictions attributed to uncharacterized biological phenomena/e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9d8d9ce8429cada8fffa7d4e34c9573d
https://pubmed.ncbi.nlm.nih.gov/35636770
https://pubmed.ncbi.nlm.nih.gov/35636770
Autor:
Kuen Yeap, John S. Wai, Maia Vinogradova, Yu Zhong, Lori Friedman, Xiaojing Wang, Daniel Otwine, Jiangpeng Liao, Nick Ray, James R. Kiefer, Vidhi Mody, Jun Li, Fabien Roussel, Deepak Sampath, Simon Charles Goodacre, Jun Liang, Michelle Nannini, Sharada Labadie, Xiaoping Zheng, Ellen Ingalla, Steven J. Hartman, Birong Zhang, Jae H. Chang, Tao Wang, Yingqing Ran, Jason R. Zbieg, Amy Sambrone, Kwong Wah Lai, Amy Young, Ciara Metcalfe, Neville James Mclean, Robert A. Blake, Tracy Kleinheinz
Publikováno v:
ACS Med Chem Lett
[Image: see text] Estrogen receptor alpha (ERα) is a well-validated drug target for ER-positive (ER+) breast cancer. Fulvestrant is FDA-approved to treat ER+ breast cancer and works through two mechanisms—as a full antagonist and selective estroge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe42f6062f9f361a3f700a527fd2a8dc
https://doi.org/10.1021/acsmedchemlett.0c00224
https://doi.org/10.1021/acsmedchemlett.0c00224
Autor:
Martin O'Rourke, Nicholas Charles Ray, Thomas Gelzleichter, Leah Schutt, Ellen Ingalla, Neville James Mclean, Xiaojing Wang, Stephen Daly, Yingqing Ran, Jiangpeng Liao, Tommy Lai, Yu Zhong, Jun Liang, Sharada Labadie, Lori Friedman, Amy Sambrone, Jun Li, Robert A. Blake, Tao Wang, Liu Zhiguo, Birong Zhang, Steven J. Hartman, Jae H. Chang, Wei Zhou, Jane Guan, Vidhi Mody, Jonathan White, Fabien Roussel, Antonio G. DiPasquale, Jason R. Zbieg, Daniel F. Ortwine, Amy Young, James R. Kiefer, Maia Vinogradova, Simon Charles Goodacre, Deepak Sampath, Tracy Kleinheinz, Xiaoping Zheng, Jennifer M. Giltnane, Lorn Kategaya, Ingrid E. Wertz, Matthew Gill, Ciara Metcalfe, Siew Kuen Yeap, John S. Wai, Jason Oeh, Michelle Nannini
Publikováno v:
Journal of medicinal chemistry. 64(16)
Breast cancer remains a leading cause of cancer death in women, representing a significant unmet medical need. Here, we disclose our discovery efforts culminating in a clinical candidate, 35 (GDC-9545 or giredestrant). 35 is an efficient and potent s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee86fe3f8068fbb2ff9647a59eadb710
https://pubmed.ncbi.nlm.nih.gov/34251202
https://pubmed.ncbi.nlm.nih.gov/34251202
Autor:
Michael Ward, David H. Hackos, Michel Friesenhahn, Jae H. Chang, Michael E. Rothenberg, Janel M. Boyce-Rustay, Michael Tagen, Dan Sutherlin, William Cho, Avis Hains
Publikováno v:
Clinical Drug Investigation. 39:873-887
The original version of this article unfortunately contained a mistake. A few entries were incorrect in Table 2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f218c2c4a39ccbd547c90f60f2b5f753
https://doi.org/10.1007/s40261-019-00807-3
https://doi.org/10.1007/s40261-019-00807-3
Autor:
Jodie Pang, Lunbin Deng, Girish Bankar, Jun Chen, Sultan Chowdhury, William R Proctor, Philippe Bergeron, Jennifer Vogt, Daniel F. Ortwine, Daniel P. Sutherlin, Jian Payandeh, Lilia Schumann, Shannon D. Shields, Christoph Martin Dehnhardt, Jae H. Chang, David H. Hackos, Elisa Ballini, Teresa Nguyen, Pengfei Ji, Glauco Tarozzo, Charles J. Cohen, Antonio G. DiPasquale, Kwong Wah Lai, Jonathan Maher, Kuldip Khakh, Steven J. McKerrall, Tania Chernov-Rogan, Wenfeng Liu, Brian Safina, Sophia Lin, Abid Hasan, J. P. Johnson
Publikováno v:
Journal of Medicinal Chemistry. 62:4091-4109
Using structure- and ligand-based design principles, a novel series of piperidyl chromane arylsulfonamide Nav1.7 inhibitors was discovered. Early optimization focused on improvement of potency through refinement of the low energy ligand conformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::824349f727cab11e6b607d5268a59967
https://doi.org/10.1021/acs.jmedchem.9b00141
https://doi.org/10.1021/acs.jmedchem.9b00141
Autor:
Kyle A. Edgar, Amy Young, Jared Moore, Xi Chen, Wei Fang, Jae H. Chang, Wayne Kong, Jason E. Long, Aleksandr Pankov, Anneleen Daemen, Daniel G. Shore, Robert Warne, Paul Gibbons, Chudi O. Ndubaku, Melissa R. Junttila, Lori S. Friedman
Publikováno v:
Cancer Research. 82:2633-2633
Amplification and copy number alterations of the 17q23 amplicon are common in breast cancer and neuroblastoma and have been associated with early relapse and poor prognosis. Recent work identified a key vulnerability associated with amplicon-driven o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eaffc3f878f0559ccf8420f27e6889ca
https://doi.org/10.1158/1538-7445.am2022-2633
https://doi.org/10.1158/1538-7445.am2022-2633