Mechanisms underlying cognitive deficits in a mouse model for Costello Syndrome are distinct from other RASopathy mouse models

Autor: Jadwiga Schreiber, Laura-Anne Grimbergen, Iris Overwater, Thijs van der Vaart, Jeffrey Stedehouder, Alberto J. Schuhmacher, Carmen Guerra, Steven A. Kushner, Dick Jaarsma, Ype Elgersma

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-19 (2017)

Abstract RASopathies, characterized by germline mutations in genes encoding proteins of the RAS-ERK signaling pathway, show overlapping phenotypes, which manifest themselves with a varying severity of intellectual disability. However, it is unclear t

Externí odkaz: https://doaj.org/article/e97ef2c4374149b689e3417c7b683ad5

Effects of antiepileptic drugs in a new TSC/mTOR-dependent epilepsy mouse model

Autor: Martina Proietti Onori, Ilse Wallaard, Annabel van Oort, Nathalie H. R. M. Kooijman, Ype Elgersma, Saskia E. van Grondelle, Linda M. C. Koene, Jadwiga Schreiber

Publikováno v: Annals of Clinical and Translational Neurology, 6(7), 1273-1291. John Wiley & Sons Inc.
Annals of Clinical and Translational Neurology, Vol 6, Iss 7, Pp 1273-1291 (2019)
Annals of Clinical and Translational Neurology

Objective An epilepsy mouse model for Tuberous Sclerosis Complex (TSC) was developed and validated to investigate the mechanisms underlying epileptogenesis. Furthermore, the possible antiepileptogenic properties of commonly used antiepileptic drugs (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a284908e7685de6348a0906222d1efad
https://pure.eur.nl/en/publications/47e571a9-4fd8-4c2c-a42a-810fb0a23c37

The Ig CAM CAR is Implicated in Cardiac Development and Modulates Electrical Conduction in the Mature Heart

Autor: René Jüttner, Fritz G. Rathjen, Claudia Matthäus, Jadwiga Schreiber

Publikováno v: Journal of Cardiovascular Development and Disease, Vol 1, Iss 1, Pp 111-120 (2014)

The coxsackievirus and adenovirus receptor (CAR, CXADR) is a multi-functional cell adhesion molecule which forms with CLMP, BT-IgSF, ESAM and CTX a structural subgroup within the Ig superfamily. These proteins share an overall domain organization wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8df3271ba9e57a907482267aee4ac2b0
https://doi.org/10.3390/jcdd1010111

The Coxsackievirus–Adenovirus Receptor Reveals Complex Homophilic and Heterophilic Interactions on Neural Cells

Autor: Jadwiga Schreiber, Fritz G. Rathjen, Hannes Schmidt, Klaas E.A. Max, Joachim Behlke, Stephan Kröger, Christopher Patzke, Albrecht Otto, Mechthild Henning, Armin A. Dorner, Udo Heinemann

Publikováno v: The Journal of Neuroscience. 30:2897-2910

The coxsackievirus–adenovirus receptor (CAR) is a member of the Ig superfamily strongly expressed in the developing nervous system. Our histological investigations during development reveal an initial uniform distribution of CAR on all neural cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e100c3c1fa934c01f235b4066b37d95
https://doi.org/10.1523/jneurosci.5725-09.2010

The IgCAMs CAR, BT-IgSF, and CLMP: Structure, Function, and Diseases

Autor: Jadwiga Schreiber, Hanna Langhorst, Fritz G. Rathjen, René Jüttner

Publikováno v: Advances in Neurobiology ISBN: 9781461480891

The coxsackie-adenovirus receptor (CAR) is the prototype of a small subfamily of IgCAMs composed of CAR itself, CLMP, BT-IgSF, ESAM, CTX, and A33. These six proteins are composed of one V-set and one C2-set Ig domains and a single transmembrane helix

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee6794d53cdc1b42441bf23ab359736b
https://doi.org/10.1007/978-1-4614-8090-7_2