Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jadwiga Miotla, Zarebska"'
Autor:
Maria Dzamukova, Tobias M. Brunner, Jadwiga Miotla-Zarebska, Frederik Heinrich, Laura Brylka, Mir-Farzin Mashreghi, Anjali Kusumbe, Ralf Kühn, Thorsten Schinke, Tonia L. Vincent, Max Löhning
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The study shows that mechanical forces trigger secretion of the extracellular matrix protein dentin matrix protein 1 from osteoblasts. This transforms bone growth-promoting blood vessels into a quiescent subtype to limit bone growth at the end of ado
Externí odkaz:
https://doaj.org/article/6aebe5fcbba74c2caa9172547833f209
Autor:
Linyi Zhu, Shannah Donhou, Annika Burleigh, Jadwiga Miotla Zarebska, Marcia Curtinha, Ida Parisi, Sumayya Nafisa Khan, Francesco Dell’Accio, Anastasios Chanalaris, Tonia L. Vincent
Publikováno v:
ACR Open Rheumatology, Vol 2, Iss 10, Pp 605-615 (2020)
Objective Tumor necrosis factor α–stimulated gene 6 (TSG‐6) is an anti‐inflammatory protein highly expressed in osteoarthritis (OA), but its influence on the course of OA is unknown. Methods Cartilage injury was assessed by murine hip avulsion
Externí odkaz:
https://doaj.org/article/e77822038b8847f581cb6871c9779453
Autor:
Isabell S. von Loga, Jadwiga Miotla-Zarebska, Yi-Shu Huang, Richard Williams, Luke Jostins, Tonia L. Vincent
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 2, Iss 4, Pp 100101- (2020)
Objective: Evoked responses following mechanical or thermal stimulation are typically used to assess pain behaviour in murine osteoarthritis (OA). However, there is no consensus on how best to measure spontaneous pain behaviour. Method: OA by partial
Externí odkaz:
https://doaj.org/article/bebdf95c9809406bb78810d52c3bd586
Autor:
Linyi, Zhu, Pragash, Kamalathevan, Lada A, Koneva, Jadwiga Miotla, Zarebska, Anastasios, Chanalaris, Heba, Ismail, Akira, Wiberg, Michael, Ng, Hayat, Muhammad, John, Walsby-Tickle, James S O, McCullagh, Fiona E, Watt, Stephen N, Sansom, Dominic, Furniss, Matthew D, Gardiner, Tonia L, Vincent, Nick, Riley, Michelle, Spiteri, Ian, McNab, Christopher, Little, Lucy, Cogswell, Paul, Critchley, Henk, Giele, Rebecca, Shirley
Publikováno v:
Science translational medicine. 14(676)
More than 40% of individuals will develop osteoarthritis (OA) during their lifetime, yet there are currently no licensed disease-modifying treatments for this disabling condition. Common polymorphic variants in
Publikováno v:
Cartilage Tissue Engineering ISBN: 9781071628386
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ca7f9c7eed94383af625b47a06ad6b5
https://doi.org/10.1007/978-1-0716-2839-3_26
https://doi.org/10.1007/978-1-0716-2839-3_26
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2598
In this chapter, we describe an induced model of osteoarthritis in mice, frequently employed in the study of this disease. We outline in detail the surgical induction of disease and preparation of samples for histological assessment of disease.
Autor:
Clarissa R Coveney, Hasmik J Samvelyan, Jadwiga Miotla‐Zarebska, Josephine Carnegie, Emer Chang, C Jonty Corrin, Trystan Coveney, Bryony Stott, Ida Parisi, Claudia Duarte, Tonia L Vincent, Katherine A Staines, Angus KT Wann
Compared with our understanding of endochondral ossification, much less is known about the coordinated arrest of growth defined by the narrowing and fusion of the cartilaginous growth plate. Throughout the musculoskeletal system, appropriate cell and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d1ced8e28241dc55c9f61686088daf
https://ora.ox.ac.uk/objects/uuid:7e554552-f923-4513-9335-1faa4100d582
https://ora.ox.ac.uk/objects/uuid:7e554552-f923-4513-9335-1faa4100d582
Autor:
Maria Dzamukova, Tobias M. Brunner, Jadwiga Miotla-Zarebska, Frederik Heinrich, Laura Brylka, Mir-Farzin Mashreghi, Anjali Kusumbe, Ralf Kühn, Thorsten Schinke, Tonia L. Vincent, Max Löhning
Publikováno v:
Nature communications. 13(1)
Bone growth requires a specialised, highly angiogenic blood vessel subtype, so-called type H vessels, which pave the way for osteoblasts surrounding these vessels. At the end of adolescence, type H vessels differentiate into quiescent type L endothel
Autor:
Heba M, Ismail, Jadwiga, Miotla-Zarebska, Linda, Troeberg, Xiaodi, Tang, Bryony, Stott, Kazuhiro, Yamamoto, Hideaki, Nagase, Amanda J, Fosang, Tonia L, Vincent, Jeremy, Saklatvala
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.). 68(5)
The pathogenesis of osteoarthritis (OA) is poorly understood. Loss of the proteoglycan aggrecan from cartilage is an early event. Recently, we identified a role for the JNK pathway, particularly JNK-2, in human articular chondrocytes in vitro in regu