Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Jadwiga M. Giebultowicz"'
Autor:
Benjamin Sebastian, Rosalyn M. Fey, Patrick Morar, Brittany Lasher, Jadwiga M. Giebultowicz, David A. Hendrix
Publikováno v:
Journal of Circadian Rhythms, Vol 20 (2022)
Many critical life processes are regulated by input from 24-hour external light/dark cycles, such as metabolism, cellular homeostasis, and detoxification. The circadian clock, which helps coordinate the response to these diurnal light/dark cycles, re
Externí odkaz:
https://doaj.org/article/174f28bc64ab4e2195bcda09f476dcab
Autor:
Jun Yang, Yujuan Song, Alexander D. Law, Conner J. Rogan, Kelsey Shimoda, Danijel Djukovic, Jeffrey C. Anderson, Doris Kretzschmar, David A. Hendrix, Jadwiga M. Giebultowicz
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Blue light (BL) is becoming increasingly prevalent in artificial illumination, raising concerns about its potential health hazard to humans. In fact, there is evidence suggesting that acute BL exposure may lead to oxidative stress and death of retina
Externí odkaz:
https://doaj.org/article/86ef98bb2b204c55afe828ffcf464c6c
Autor:
Alexander D. Law, Marlène Cassar, Dani M. Long, Eileen S. Chow, Jadwiga M. Giebultowicz, Anjana Venkataramanan, Roland Strauss, Doris Kretzschmar
Publikováno v:
Neurobiology of Disease, Vol 170, Iss , Pp 105770- (2022)
Although mutations in the microtubules-associated protein Tau have long been connected with several neurodegenerative diseases, the underlying molecular mechanisms causing these tauopathies are still not fully understood. Studies in various models su
Externí odkaz:
https://doaj.org/article/5662c98be9934fca882e7065b3adf1e7
Autor:
Trevor R. Nash, Eileen S. Chow, Alexander D. Law, Samuel D. Fu, Elzbieta Fuszara, Aleksandra Bilska, Piotr Bebas, Doris Kretzschmar, Jadwiga M. Giebultowicz
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 5, Iss 1, Pp 1-8 (2019)
Abstract Light is necessary for life, but prolonged exposure to artificial light is a matter of increasing health concern. Humans are exposed to increased amounts of light in the blue spectrum produced by light-emitting diodes (LEDs), which can inter
Externí odkaz:
https://doaj.org/article/b5a13df9da704333ac49a61936553663
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
A hallmark feature of Alzheimer’s disease (AD) and other Tauopathies, like Frontotemporal Dementia with Parkinsonism linked to chromosome 17 (FTDP-17), is the accumulation of neurofibrillary tangles composed of the microtubule-associated protein Ta
Externí odkaz:
https://doaj.org/article/6b32aeac766e4116acc3e5210b2b4f86
Autor:
Rachael C. Kuintzle, Eileen S. Chow, Tara N. Westby, Barbara O. Gvakharia, Jadwiga M. Giebultowicz, David A Hendrix
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Disruption of circadian rhythms leads to reduced healthspan, but the mechanisms by which the normal clock protects aging organisms are not known. Here, the authors show that a subset of genes becomes more rhythmically expressed in older flies, and th
Externí odkaz:
https://doaj.org/article/72d2f017cdf647a7826f0fc41de1759f
Autor:
Dani M. Long, Jadwiga M. Giebultowicz
Publikováno v:
Frontiers in Physiology, Vol 8 (2018)
Circadian clocks consist of molecular negative feedback loops that coordinate physiological, neurological, and behavioral variables into “circa” 24-h rhythms. Rhythms in behavioral and other circadian outputs tend to weaken during aging, as evide
Externí odkaz:
https://doaj.org/article/f648a737101744a2b5b84e157c6d4146
Autor:
Matthew R. Blake, Scott D. Holbrook, Joanna Kotwica-Rolinska, Eileen S. Chow, Doris Kretzschmar, Jadwiga M. Giebultowicz
Publikováno v:
Neurobiology of Disease, Vol 77, Iss , Pp 117-126 (2015)
Alzheimer's disease (AD) is a neurodegenerative disease characterized by severe cognitive deterioration. While causes of AD pathology are debated, a large body of evidence suggests that increased cleavage of Amyloid Precursor Protein (APP) producing
Externí odkaz:
https://doaj.org/article/a6290416fee14b209f00b2a63e95b552
Autor:
Natraj Krishnan, Kuntol Rakshit, Eileen S. Chow, Jill S. Wentzell, Doris Kretzschmar, Jadwiga M. Giebultowicz
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 3, Pp 1129-1135 (2012)
Circadian clocks generate rhythms in molecular, cellular, physiological, and behavioral processes. Recent studies suggest that disruption of the clock mechanism accelerates organismal senescence and age-related pathologies in mammals. Impaired circad
Externí odkaz:
https://doaj.org/article/0ac48a79343d4cfe83238c5b629d010f
Autor:
Yujuan Song, Jun Yang, Alexander D. Law, David A. Hendrix, Doris Kretzschmar, Matthew Robinson, Jadwiga M. Giebultowicz
Publikováno v:
npj Aging. 8
Blue light is a predominant component of light emitting devices (LEDs), which are increasingly present in our environment. There is already accumulating evidence that blue light exposure causes damage to retinal cells in vitro and in vivo; however, m