Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jadwiga K. Kepa"'
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44861 (2012)
NAD(P)H:quinone oxidoreductase 1 (NQO1) is an FAD containing quinone reductase that catalyzes the 2-electron reduction of a broad range of quinones. The 2-electron reduction of quinones to hydroquinones by NQO1 is believed to be a detoxification proc
Externí odkaz:
https://doaj.org/article/9e9acc21d74941ae88af12d8800c8e47
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 336:874-880
Previous work demonstrated that NAD(P)H:quinone oxidoreductase 1 (NQO1) metabolized the heat shock protein 90 (Hsp90) inhibitor 17-(allylamino)-17-demethoxygeldanamycin (17AAG) to the corresponding hydroquinone (17AAGH₂). The formation of 17AAGH₂
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f116a18e31fced7e2b7a4ea125fd50a
https://doi.org/10.1124/jpet.110.176438
https://doi.org/10.1124/jpet.110.176438
Publikováno v:
Molecular Pharmacology. 74:1657-1665
2,5-Diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1) is a novel antitumor diaziridinyl benzoquinone derivative designed to be bioactivated by the two-electron reductase NAD(P)H:quinone oxidoreductase (NQO1) and is currently in clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::554d7d4b2f0a9cf4714f9a81efdf30f5
https://doi.org/10.1124/mol.108.050401
https://doi.org/10.1124/mol.108.050401
Autor:
David Siegel, Andrea L. Merz, Michael E. Long, David Ross, Jeffrey C. Rastatter, Daniel L. Gustafson, Jadwiga K. Kepa, Jacqueline C. Parpal
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 305:1079-1086
The bioreductive activation of the antitumor quinone mitomycin C (MMC) by NAD(P)H: quinone oxidoreductase 1 (NQO1) is complicated by the ability of MMC to also act as a mechanism-based inhibitor of NQO1 in a pH dependent manner. Inhibition of NQO1 by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6296f5fc9e1ba8eb6722715e04628e3
https://doi.org/10.1124/jpet.103.050070
https://doi.org/10.1124/jpet.103.050070
Autor:
David Siegel, David Ross, Luo Jia Tang, Jadwiga K. Kepa, Donna L. Dehn, Adil Anwar, Jennifer A. Pietenpol
Publikováno v:
Journal of Biological Chemistry. 278:10368-10373
NAD(P)H:quinone oxidoreductase 1 (NQO1) has been proposed to stabilize p53 via a redox mechanism involving oxidation of NAD(P)H as a consequence of the catalytic activity of NQO1. We report that treatment of HCT-116 human colon carcinoma cells with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8f4a5699338fc8df09ed28d5e8fb10
https://doi.org/10.1074/jbc.m211981200
https://doi.org/10.1074/jbc.m211981200
Publikováno v:
Chemico-Biological Interactions. 129:77-97
NAD(P)H:quinone oxidoreductase 1 (NQO1) is an obligate two-electron reductase that is involved in chemoprotection and can also bioactivate certain antitumor quinones. This review focuses on detoxification reactions catalyzed by NQO1 and its role in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a65af034d90756da60c46fd7c59d299
https://doi.org/10.1016/s0009-2797(00)00199-x
https://doi.org/10.1016/s0009-2797(00)00199-x
Autor:
Jadwiga K. Kepa, Philip Reigan, Andrew M. Donson, Christopher C. Franklin, Dennis R. Petersen, Kristofer S. Fritz, Nicholas K. Foreman, Donald S. Backos, Debbie G. McArthur
Publikováno v:
Neurochemical research. 38(9)
The antioxidant glutathione (GSH) plays a critical role in maintaining intracellular redox homeostasis but in tumors the GSH biosynthetic pathway is often dysregulated, contributing to tumor resistance to radiation and chemotherapy. Glutamate-cystein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9965789ebf248cc208aabc8aa5cbec
https://pubmed.ncbi.nlm.nih.gov/23743623
https://pubmed.ncbi.nlm.nih.gov/23743623
Autor:
Eric A. Boen, Glenn S. Takimoto, Paul Prendergast, Jadwiga K. Kepa, Margaret E. Wierman, Dean P. Edwards, Britta M. Jacobsen
Publikováno v:
Molecular and Cellular Endocrinology. 117:27-39
The mechanisms by which steroid receptors repress gene expression are not well understood. In this report, we show that progesterone receptor (PR), in the presence of progesterone (P) directly represses rat gonadotropin releasing hormone (rGnRH) gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b69af073dea0224a888a645eb4dc388
https://doi.org/10.1016/0303-7207(95)03723-3
https://doi.org/10.1016/0303-7207(95)03723-3
Publikováno v:
Cellular and Molecular Neurobiology. 15:79-88
1. Gonadotropin-releasing hormone (GnRH) is the hypothalamic releasing factor that controls pituitary gonadotropin subunit gene expression and indirectly gametogenesis and steroidogenesis from the gonad, which results in reproductive competence. 2. G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a755378e1eceb91f2d83774a6eefef6b
https://doi.org/10.1007/bf02069559
https://doi.org/10.1007/bf02069559
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 334(1)
NAD(P)H:quinone oxidoreductase 1 (NQO1) deficiency resulting from a homozygous NQO1*2 polymorphism has been associated with an increased risk of benzene-induced myeloid toxicity and a variety of de novo and therapy-induced leukemias. Endothelial cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411ef5e076ff52d1b9108a89aec14c55
https://pubmed.ncbi.nlm.nih.gov/20378716
https://pubmed.ncbi.nlm.nih.gov/20378716