Zobrazeno 1 - 10
of 263
pro vyhledávání: '"Jadwiga, Handzlik"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10652 (2024)
Perry disease (PeD) is a rare, neurodegenerative, genetic disorder inherited in an autosomal dominant manner. The disease manifests as parkinsonism, with psychiatric symptoms on top, such as depression or sleep disorders, accompanied by unexpected we
Externí odkaz:
https://doaj.org/article/232be020a7e84cecb6a8035996edbfbe
Autor:
Magdalena Łysakowska, Iwona E. Głowacka, Ewelina Honkisz-Orzechowska, Jadwiga Handzlik, Dorota G. Piotrowska
Publikováno v:
Molecules, Vol 29, Iss 13, p 3050 (2024)
In this study, a new series of cis and trans 5-substituted-3-(dibenzyloxyphosphoryl)isoxazolidines 16a–g were synthesized by the 1,3-dipolar cycloaddition reaction of N-benzyl-C-(dibenzyloxyphosphoryl)nitrone and selected N1-allyl-N3-benzylquinazol
Externí odkaz:
https://doaj.org/article/b6bb75c24596445f9790ed339e54bf83
Autor:
Ewelina Honkisz-Orzechowska, Olga Barczyk-Woźnicka, Maria Kaleta, Jadwiga Handzlik, Katarzyna Kieć-Kononowicz
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6100 (2024)
This study demonstrated the anticancer efficacy of chalcones with indole moiety (MIPP, MOMIPP) in fibrosarcoma cells for the first time. The results showed that MIPP and MOMIPP reduced the viability of HT-1080 cells in a concentration-dependent manne
Externí odkaz:
https://doaj.org/article/fa698ba49c88436f95702c1791025128
Autor:
Damian Bartuzi, Ewa Kędzierska, Katarzyna M. Targowska-Duda, Oliwia Koszła, Tomasz M. Wróbel, Simon Jademyr, Tadeusz Karcz, Katarzyna Szczepańska, Piotr Stępnicki, Olga Wronikowska-Denysiuk, Grażyna Biała, Jadwiga Handzlik, Jesper L. Kristensen, Antti Poso, Agnieszka A. Kaczor
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Anxiety is a troublesome symptom for many patients, especially those suffering from schizophrenia. Its regulation involves serotonin receptors, targeted e.g. by antipsychotics or psychedelics such as LSD. 5-HT2A receptors are known for an ex
Externí odkaz:
https://doaj.org/article/e8d54c16692c4f768e6532bff908e43f
Autor:
Aneta Kaczor, Joanna Knutelska, Katarzyna Kucwaj-Brysz, Małgorzata Zygmunt, Ewa Żesławska, Agata Siwek, Marek Bednarski, Sabina Podlewska, Magdalena Jastrzębska-Więsek, Wojciech Nitek, Jacek Sapa, Jadwiga Handzlik
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 16609 (2023)
In order to find new hypotensive drugs possessing higher activity and better selectivity, a new series of fifteen 5,5-dimethylhydantoin derivatives (1–15) was designed. Three-step syntheses, consisting of N-alkylations using standard procedures as
Externí odkaz:
https://doaj.org/article/cee6fa445dd2407ca81ed8f23a1464ab
Autor:
Karolina Witek, Aneta Kaczor, Ewa Żesławska, Sabina Podlewska, Małgorzata Anna Marć, Kinga Czarnota-Łydka, Wojciech Nitek, Gniewomir Latacz, Waldemar Tejchman, Markus Bischoff, Claus Jacob, Jadwiga Handzlik
Publikováno v:
Antibiotics, Vol 12, Iss 11, p 1618 (2023)
In this study, a search for new therapeutic agents that may improve the antibacterial activity of conventional antibiotics and help to successfully overcome methicillin-resistant Staphylococcus aureus (MRSA) infections has been conducted. The purpose
Externí odkaz:
https://doaj.org/article/b86e873063524db1aa3c92b6214f256f
Autor:
Paweł Zagrodzki, Agnieszka Wiesner, Monika Marcinkowska, Marek Jamrozik, Enrique Domínguez-Álvarez, Katarzyna Bierła, Ryszard Łobiński, Joanna Szpunar, Jadwiga Handzlik, Agnieszka Galanty, Shela Gorinstein, Paweł Paśko
Publikováno v:
Molecules, Vol 28, Iss 5, p 2062 (2023)
Due to problems with selenium deficiency in humans, the search for new organic molecules containing this element in plant biofortification process is highly required. Selenium organic esters evaluated in this study (E-NS-4, E-NS-17, E-NS-71, EDA-11,
Externí odkaz:
https://doaj.org/article/c222e90068d14678851c1e65ad7ef7e1
Publikováno v:
Antibiotics, Vol 12, Iss 2, p 290 (2023)
Organic selenocyanates (RSeCN) are among the most reactive and biologically active Se species, often exhibiting a pronounced cytotoxic activity against mammalian cells and microorganisms. Various aromatic selenocyanates have been synthesized and, sim
Externí odkaz:
https://doaj.org/article/4d3b3512aff14112b0c558f070f5588b
Autor:
Dorota Łażewska, Małgorzata Więcek, Grzegorz Satała, Paulina Chałupnik, Ewa Żesławska, Ewelina Honkisz-Orzechowska, Monika Tarasek, Gniewomir Latacz, Wojciech Nitek, Ewa Szymańska, Jadwiga Handzlik
Publikováno v:
Molecules, Vol 28, Iss 3, p 1108 (2023)
Since the number of people with Alzheimer’s disease (AD) continues to rise, new and effective drugs are urgently needed to not only slow down the progression of the disease, but to stop or even prevent its development. Serotonin 5-HT6 receptor (5-H
Externí odkaz:
https://doaj.org/article/2818bbb54cea49789517aaf59945ee75
Autor:
Justyna Godyń, Paula Zaręba, Dorota Stary, Maria Kaleta, Kamil J. Kuder, Gniewomir Latacz, Szczepan Mogilski, David Reiner-Link, Annika Frank, Agata Doroz-Płonka, Agnieszka Olejarz-Maciej, Sylwia Sudoł-Tałaj, Tobias Nolte, Jadwiga Handzlik, Holger Stark, Anna Więckowska, Barbara Malawska, Katarzyna Kieć-Kononowicz, Dorota Łażewska, Marek Bajda
Publikováno v:
Molecules, Vol 28, Iss 1, p 238 (2022)
The multitarget-directed ligands demonstrating affinity to histamine H3 receptor and additional cholinesterase inhibitory potency represent a promising strategy for research into the effective treatment of Alzheimer’s disease. In this study, a nove
Externí odkaz:
https://doaj.org/article/2481fe283dea45f89bc7efb49683033f