Výsledky vyhledávání

High Resolution Mapping of the Binding Site on Human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and Design of IgG1 Variants with Improved Binding to the FcγR

Autor: Josephine P. Briggs, Kyu Hong, Leonard G. Presta, Betty Li, Angela K. Namenuk, Judith A. Fox, Dong Xie, Julie Rae, Y. Gloria Meng, Jadine Lai, Andrew Stadlen, Robert L. Shields

Publikováno v: Journal of Biological Chemistry. 276:6591-6604

Immunoglobulin G (IgG) Fc receptors play a critical role in linking IgG antibody-mediated immune responses with cellular effector functions. A high resolution map of the binding site on human IgG1 for human FcγRI, FcγRIIA, FcγRIIB, FcγRIIIA, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef7f21b94ef831ce45a573066d3f0fd3
https://doi.org/10.1074/jbc.m009483200

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Cardiac fibroblasts produce leukemia inhibitory factor and endothelin, which combine to induce cardiac myocyte hypertrophy in vitro

Autor: Jane Winer, Jeff Hooley, Jennie P. Mather, Jadine Lai, Kathleen L. King, P. Mickey Williams, Elizabeth Luis, Randy Yen

Publikováno v: Endocrine. 5:85-93

Cardiac fibroblasts in culture produce factor(s) that induce hypertrophy of neonatal rat ventricular myocytes in vitro. As in vivo, the myocyte hypertrophy response in culture is characterized by an increase in cell size and contractile protein conte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c72dfb8239a96a672d41a40b5ee74dfd
https://doi.org/10.1007/bf02738660

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Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity

Autor: Robert L. Shields, Leonard G. Presta, Kyu Hong, Y. Gloria Meng, Lori Y. O'Connell, Rodney G. Keck, Stefanie Weikert, Jadine Lai

Publikováno v: The Journal of biological chemistry. 277(30)

Lec13 cells, a variant Chinese hamster ovary cell line, were used to produce human IgG1 that were deficient in fucose attached to the Asn(297)-linked carbohydrate but were otherwise similar to that found in IgG1 produced in normal Chinese hamster ova

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9def7fb0eaca351ab37ac9b2b8f2a2fd
https://pubmed.ncbi.nlm.nih.gov/11986321

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Characterization and humanization of a monoclonal antibody that neutralizes human leukocyte interferon: a candidate therapeutic for IDDM and SLE

Autor: Timothy A. Stewart, K. Jin Kim, Leonard G. Presta, Verna Gibbs, Jadine Lai, Anan Chuntharapai, Xiaojian Huang

Publikováno v: Cytokine. 15(5)

We have developed a panel of murine monoclonal antibodies that recognize human interferon alpha. One of these mononclonal antibodies binds and neutralizes, with high affinity, all of seven tested recombinant human interferon alphas. This mononclonal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b1e4d7d8a604d0576e070e11457cad
https://pubmed.ncbi.nlm.nih.gov/11594789

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Akademický článek

Prostaglandin F2alpha induces cardiac myocyte hypertrophy in vitro and cardiac growth in vivo.

Autor: Lai, Jadine, Jin, Hongkui

Publikováno v: American Journal of Physiology: Heart & Circulatory Physiology; Dec96, Vol. 271 Issue 6, pH2197, 12p, 8 Color Photographs, 9 Black and White Photographs, 1 Chart, 9 Graphs

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Elektronická kniha

Autoimmune Disorders: Risk Factors, Pathogenesis and Treatments

Autor: Kutty Selva Nandakumar

Autoimmune diseases (ADs) occur when the immune system is mistakenly activated and attacks self antigens present in our body, leading to tissue destruction. Increasing prevalence of ADs is not only a problem for the affected patients but also causes

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