Structural and biochemical characterization of Leptospira interrogans Lsa45 reveals a penicillin-binding protein with esterase activity

Autor: Jademilson C. Santos, Sumit Handa, Luis G.V. Fernandes, Lucas Bleicher, César A. Gandin, Mario de Oliveira-Neto, Partho Ghosh, Ana Lucia T.O. Nascimento

Publikováno v: Process Biochemistry. 125:141-153

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32d4f70435c413168848f7104df7ed2f
https://doi.org/10.1016/j.procbio.2022.12.010

An epoxide hydrolase from endophytic Streptomyces shows unique structural features and wide biocatalytic activity

Autor: Luciana G. de Oliveira, Gabriel S. de Oliveira, Gabriela D. Tormet-González, Carolina Wilson, Jademilson C. Santos, Marcio Vinicius Bertacine Dias

Publikováno v: Acta Crystallographica. Section D, Structural Biology
Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The crystal structure of an epoxide hydrolase from Streptomyces sp. CBMAI 2042 was determined and revealed the conserved overall fold found in other α/β-hydrolases, despite its unusual hexameric quaternary structure. Although its primary sequence i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0b425ec546b93a8e69df80dcae74e8
http://europepmc.org/articles/PMC7466753

Tetrazoles as PPARγ ligands: A structural and computational investigation

Autor: Karina de Paula, Alessandro S. Nascimento, Jademilson C. Santos, Ana Carolina Mafud

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Diabetes is an important chronic disease affecting about 10% of the adult population in the US and over 420 million people worldwide, resulting in 1.6 million deaths every year, according to the World Health Organization. The most common type of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4296957b0dc66f1b0f352629ec09075d
https://doi.org/10.1016/j.jmgm.2021.107932

Purification, crystallization and preliminary crystallographic analysis of peroxidase from the palm tree Chamaerops excelsa

Autor: Jademilson C. Santos, Igor Polikarpov, Larissa C. Textor, Galina G. Zhadan, Valery L. Shnyrov, Manuel G. Roig, Nazaret Hidalgo Cuadrado

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Plant peroxidases are presently used extensively in a wide range of biotechnological applications owing to their high environmental and thermal stability. As part of efforts towards the discovery of appealing new biotechnological enzymes, the peroxid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4eed061386822b570c674d8a2e7a94
https://doi.org/10.1107/s1744309111039030

Structure-based identification of novel PPAR gamma ligands

Autor: Ana Carolina Migliorini Figueira, Jademilson C. Santos, Flávia Marinho Correia da Silva, Jessica L. O. Campos, Alessandro S. Nascimento, Igor Polikarpov, Ana Carolina Mafud

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor with an important role in the glucose metabolism and a target for type 2 diabetes mellitus therapy. The recent findings relating the use of the receptor full agonist rosigli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be3b637ea5dc1143ee5309007b1d47e2
https://pubmed.ncbi.nlm.nih.gov/24075729