Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jade M. Katinas"'
Autor:
Nian Tong, Jennifer Wong-Roushar, Adrianne Wallace-Povirk, Yesha Shah, Morgan C. Nyman, Jade M. Katinas, Mathew Schneider, Carrie O’Connor, Xun Bao, Seongho Kim, Jing Li, Zhanjun Hou, Larry H. Matherly, Charles E. Dann, Aleem Gangjee
Publikováno v:
ACS Pharmacology & Translational Science. 6:748-770
Autor:
Larry H. Matherly, Aleem Gangjee, Charles E. Dann, Zhanjun Hou, Jing Li, Joshua D. Rabinowitz, Lisa Polin, Maik Hüttemann, Seongho Kim, Juiwanna Kushner, Kathryn White, Sijana H. Dzinic, Carrie O'Connor, Adrianne Wallace-Povirk, Jenney Liu, Josephine Frühauf, Xun Bao, Changwen Ning, Arpit Doshi, Md. Junayed Nayeen, Jennifer Wong-Roushar, Jade M. Katinas, Gregory S. Ducker, Khushbu Shah, Aamod S. Dekhne
Supplementary Method Descriptions Molecular modeling and computational studies Enzyme expression and purification. In vitro enzymatic assays and Ki determinations In vivo efficacy trials with MIA PaCa-2 pancreatic cancer xenografts. Cytochrome c oxid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc08fe908fb7939bc9f8ad0ffe9cbc1
https://doi.org/10.1158/1535-7163.22505520
https://doi.org/10.1158/1535-7163.22505520
Autor:
Larry H. Matherly, Aleem Gangjee, Charles E. Dann, Zhanjun Hou, Jing Li, Joshua D. Rabinowitz, Lisa Polin, Maik Hüttemann, Seongho Kim, Juiwanna Kushner, Kathryn White, Sijana H. Dzinic, Carrie O'Connor, Adrianne Wallace-Povirk, Jenney Liu, Josephine Frühauf, Xun Bao, Changwen Ning, Arpit Doshi, Md. Junayed Nayeen, Jennifer Wong-Roushar, Jade M. Katinas, Gregory S. Ducker, Khushbu Shah, Aamod S. Dekhne
Folate-dependent one-carbon (C1) metabolism is compartmentalized into the mitochondria and cytosol and supports cell growth through nucleotide and amino acid biosynthesis. Mitochondrial C1 metabolism, including serine hydroxymethyltransferase (SHMT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4253307c713eb35fa04c2ec4fe8823be
https://doi.org/10.1158/1535-7163.c.6538104.v1
https://doi.org/10.1158/1535-7163.c.6538104.v1
Autor:
Larry H. Matherly, Aleem Gangjee, Charles E. Dann, Zhanjun Hou, Jing Li, Joshua D. Rabinowitz, Lisa Polin, Maik Hüttemann, Seongho Kim, Juiwanna Kushner, Kathryn White, Sijana H. Dzinic, Carrie O'Connor, Adrianne Wallace-Povirk, Jenney Liu, Josephine Frühauf, Xun Bao, Changwen Ning, Arpit Doshi, Md. Junayed Nayeen, Jennifer Wong-Roushar, Jade M. Katinas, Gregory S. Ducker, Khushbu Shah, Aamod S. Dekhne
Supplementary Figure S1 shows in vitro antiproliferative activity and targeted pathways of previously reported AICARFTase and GARFTase inhibitors. Supplementary Figure S2 shows docking of AGF291, AGF320, and AGF347 (along with 5-formyl-THF) in human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f58160726ffe67fe411c78ec2698b22
https://doi.org/10.1158/1535-7163.22505523.v1
https://doi.org/10.1158/1535-7163.22505523.v1
Autor:
Aamod S. Dekhne, Khushbu Shah, Gregory S. Ducker, Jade M. Katinas, Jennifer Wong-Roushar, Md. Junayed Nayeen, Arpit Doshi, Changwen Ning, Xun Bao, Josephine Frühauf, Jenney Liu, Adrianne Wallace-Povirk, Carrie O'Connor, Sijana H. Dzinic, Kathryn White, Juiwanna Kushner, Seongho Kim, Maik Hüttemann, Lisa Polin, Joshua D. Rabinowitz, Jing Li, Zhanjun Hou, Charles E. Dann, Aleem Gangjee, Larry H. Matherly
Publikováno v:
Molecular Cancer Therapeutics. 22:287-287
Autor:
Jennifer Wong-Roushar, Aamod Dekhne, Charles E. Dann, Lisa Polin, Xun Bao, Seongho Kim, Jade M. Katinas, Adrianne Wallace-Povirk, Jose Cardiel Nunez, Md. Junayed Nayeen, Khushbu Shah, Zhanjun Hou, Aleem Gangjee, Carrie O'Connor, Jing Li, Larry Matherly
Publikováno v:
Cancer Research. 81:2348-2348
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. Though most patients initially respond to platinum-based therapy, the likelihood of disease reoccurrence is nearly 100%. Thus, new tumor-selective therapies for EOC are urgent
Autor:
Lisa Polin, Khushbu Shah, Zhanjun Hou, Arpit Doshi, Josephine Frühauf, Md. Junayed Nayeen, Kathryn White, Gregory S. Ducker, Jade M. Katinas, Seongho Kim, Larry H. Matherly, Changwen Ning, Adrianne Wallace-Povirk, Jing Li, Juiwanna Kushner, Maik Hüttemann, Jennifer Wong-Roushar, Carrie O'Connor, Jenney Liu, Xun Bao, Charles E. Dann, Sijana H. Dzinic, Aleem Gangjee, Joshua D. Rabinowitz, Aamod Dekhne
Folate-dependent one-carbon (C1) metabolism is compartmentalized into the mitochondria and cytosol and supports cell growth through nucleotide and amino acid biosynthesis. Mitochondrial C1 metabolism, including serine hydroxymethyltransferase (SHMT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae91497edf2a8770b4c5f8bc543f115
https://europepmc.org/articles/PMC6774887/
https://europepmc.org/articles/PMC6774887/
Autor:
Aamod Dekhne, Khushbu Shah, Gregory S. Ducker, Md. Junayed Nayeen, Jade M. Katinas, Jennifer Wong, Arpit Doshi, Xun Bao, Hasini Kalpage, Jenney Liu, Seongho Kim, Adrianne Wallace-Povirk, Changwen Ning, Carrie O'Connor, Zhanjun Hou, Lisa Polin, Jing Li, Maik Hüttemann, Joshua D. Rabinowitz, Charles E. Dann, Aleem Gangjee, Larry Matherly
Publikováno v:
Cancer Research. 79:2992-2992
Folate-dependent one-carbon metabolism (1CM) is compartmentalized in the mitochondria and cytosol and generates a number of metabolites critical to tumor propagation. Folates are taken up by the plasma membrane facilitative transporters, reduced fola
Autor:
Aleem Gangjee, Junayed Nayeen, Aamod Dekhne, Changwon Ning, Zhanjun Hou, Larry H. Matherly, Carrie O'Connor, Khushbu Shah, Jennifer Wong, Charles E. Dann, Jade M. Katinas
Publikováno v:
Cancer Research. 79:811-811
Targeting cellular one-carbon (1C) metabolism in cancer cells with pyrrolo[3,2-d]pyrimidine analogs provides in vivo antitumor efficacy. We discovered a first-in-class series of 5-substituted pyrrolo[3,2-d]pyrimidine analogs (AGF291, AGF320, AGF347)