Dynamics of macrophage polarization support Salmonella persistence in a whole living organism

Autor: Jade Leiba, Tamara Sipka, Christina Begon-Pescia, Matteo Bernardello, Sofiane Tairi, Lionello Bossi, Anne-Alicia Gonzalez, Xavier Mialhe, Emilio J Gualda, Pablo Loza-Alvarez, Anne Blanc-Potard, Georges Lutfalla, Mai E Nguyen-Chi

Publikováno v: eLife, Vol 13 (2024)

Numerous intracellular bacterial pathogens interfere with macrophage function, including macrophage polarization, to establish a niche and persist. However, the spatiotemporal dynamics of macrophage polarization during infection within host remain to

Externí odkaz: https://doaj.org/article/3af0b99d3e344f90b3211f34a283ae51

Role of LrrkA in the Control of Phagocytosis and Cell Motility in Dictyostelium discoideum

Autor: Romain Bodinier, Ayman Sabra, Jade Leiba, Anna Marchetti, Otmane Lamrabet, Imen Ayadi, Vedrana Filić, Takefumi Kawata, Igor Weber, Pierre Cosson

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

LrrkA is a Dictyostelium discoideum kinase with leucine-rich repeats. LrrkA stimulates Kil2 and intra-phagosomal killing of ingested bacteria in response to folate. In this study, we show that genetic inactivation of lrrkA also causes a previously un

Externí odkaz: https://doaj.org/article/6eb249a6e9d147ecbc50769fc28a3d7f

Phosphorylation of KasB regulates virulence and acid-fastness in Mycobacterium tuberculosis.

Autor: Catherine Vilchèze, Virginie Molle, Séverine Carrère-Kremer, Jade Leiba, Lionel Mourey, Shubhada Shenai, Grégory Baronian, Joann Tufariello, Travis Hartman, Romain Veyron-Churlet, Xavier Trivelli, Sangeeta Tiwari, Brian Weinrick, David Alland, Yann Guérardel, William R Jacobs, Laurent Kremer

Publikováno v: PLoS Pathogens, Vol 10, Iss 5, p e1004115 (2014)

Mycobacterium tuberculosis bacilli display two signature features: acid-fast staining and the capacity to induce long-term latent infections in humans. However, the mechanisms governing these two important processes remain largely unknown. Ser/Thr ph

Externí odkaz: https://doaj.org/article/49ab48b0206344a38995360212f31a12

Role of LrrkA in the Control of Phagocytosis and Cell Motility in Dictyostelium discoideum

Autor: Anna Marchetti, Romain Bodinier, Pierre Cosson, Otmane Lamrabet, Vedrana Filić, Imen Ayadi, Jade Leiba, Igor Weber, Takefumi Kawata, Ayman Sabra

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in cell and developmental biology
Frontiers in Cell and Developmental Biology

LrrkA is a Dictyostelium discoideum kinase with leucine-rich repeats. LrrkA stimulates Kil2 and intra-phagosomal killing of ingested bacteria in response to folate. In this study, we show that genetic inactivation of lrrkA also causes a previously un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b4de309a18cf30605526c386f87b3d
https://www.frontiersin.org/articles/10.3389/fcell.2021.629200/full

The Mycobacterium tuberculosis transcriptional repressor EthR is negatively regulated by Serine/Threonine phosphorylation

Autor: Séverine Carrère-Kremer, Nicolas Blondiaux, Alexandre Wohlkonig, Laurent Kremer, Alain R. Baulard, Virginie Molle, Jade Leiba, Martin Moune Dimala

Publikováno v: Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, 2014, 446 (4), pp.1132-1138. ⟨10.1016/j.bbrc.2014.03.074⟩
Biochemical and Biophysical Research Communications, Elsevier, 2014, 446 (4), pp.1132-1138. ⟨10.1016/j.bbrc.2014.03.074⟩

International audience; Recent efforts have underlined the role of Serine/Threonine Protein Kinases (STPKs) in growth, pathogenesis and cell wall metabolism in mycobacteria. Herein, we demonstrated that the Mycobacterium tuberculosis EthR, a transcri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbce88c9d281dbbcdc7c0e7fab59cd56
https://doi.org/10.1016/j.bbrc.2014.03.074