Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jade Harkin"'
Autor:
Sailee S. Lavekar, Jade Harkin, Melody Hernandez, Cátia Gomes, Shruti Patil, Kang-Chieh Huang, Shweta S. Puntambekar, Bruce T. Lamb, Jason S. Meyer
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of Aβ plaques and neurofibrillary tangles, resulting in synaptic loss and neurodegeneration. The retina is an extension of the central
Externí odkaz:
https://doaj.org/article/5b8a057306ec4cc9b99937e3d9a53d30
Autor:
Cátia Gomes, Kirstin B. VanderWall, Yanling Pan, Xiaoyu Lu, Sailee S. Lavekar, Kang-Chieh Huang, Clarisse M. Fligor, Jade Harkin, Chi Zhang, Theodore R. Cummins, Jason S. Meyer
Publikováno v:
Stem Cell Reports. 17:1636-1649
Although the degeneration of retinal ganglion cells (RGCs) is a primary characteristic of glaucoma, astrocytes also contribute to their neurodegeneration in disease states. Although studies often explore cell-autonomous aspects of RGC neurodegenerati
Autor:
Kang-Chieh Huang, Cátia Gomes, Yukihiro Shiga, Nicolas Belforte, Kirstin B. VanderWall, Sailee S. Lavekar, Clarisse M. Fligor, Jade Harkin, Adriana Di Polo, Jason S. Meyer
Autophagy dysfunction has been associated with several neurodegenerative diseases including glaucoma, characterized by the degeneration of retinal ganglion cells (RGCs). However, the mechanisms by which autophagy dysfunction promotes RGC damage remai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3178c710022f73c5afb17ec353643cf8
https://doi.org/10.1101/2023.01.04.522687
https://doi.org/10.1101/2023.01.04.522687
Autor:
Rajani M. George, Ronald M Payne, Loren J. Field, Hongyu Gao, Michael Rubart-von der Lohe, Weinian Shou, Anthony B. Firulli, Wenjun Zhang, Jade Harkin, Beth A. Firulli, Ying Liu, Kevin P. Toolan, Yunlong Liu
Publikováno v:
Cardiovasc Res
AimsTo examine the role of the basic Helix-loop-Helix (bHLH) transcription factor HAND1 in embryonic and adult myocardium.Methods and resultsHand1 is expressed within the cardiomyocytes of the left ventricle (LV) and myocardial cuff between embryonic
Autor:
Kirstin B. VanderWall, Jason S. Meyer, Sailee S. Lavekar, Kang-Chieh Huang, Priya K. Shields, Jade Harkin, Catia Gomes, Clarisse M. Fligor
Publikováno v:
Stem Cell Reports
Summary The development of the visual system involves the coordination of spatial and temporal events to specify the organization of varied cell types, including the elongation of axons from retinal ganglion cells (RGCs) to post-synaptic targets in t
Publikováno v:
Proceedings of IMPRS. 3
Humans have limited ability to repair damaged central nervous system neurons, such as retinal ganglion cells, making it critical to advance towards ways to reconstruct a patient’s retina if one suffers from trauma or a neurodegenerative disease of
Autor:
Anthony B. Firulli, Alexander G. Robling, Beth A. Firulli, Jade Harkin, Hannah Milliar, Robyn K. Fuchs, Kevin P. Toolan
Publikováno v:
Development (Cambridge, England)
The morphogenesis of the vertebrate limbs is a complex process in which cell signaling and transcriptional regulation coordinate diverse structural adaptations in diverse species. In this study, we examine the consequences of altering Hand1 dimer cho
Autor:
Kevin P. Toolan, Hannah Millar, Beth A. Firulli, Santiago Pineda, Jade Harkin, Anthony B. Firulli
Publikováno v:
Cardiovascular research. 113(14)
Aims To test if a human Hand1 frame shift mutation identified in human samples is causative of hypoplastic left heart syndrome (HLHS). Methods and results HLHS is a poorly understood single ventricle congenital heart defect that affects two to three