Aη-α and Aη-β peptides impair LTP ex vivo within the low nanomolar range and impact neuronal activity in vivo

Autor: Maria Mensch, Jade Dunot, Sandy M. Yishan, Samuel S. Harris, Aline Blistein, Alban Avdiu, Paula A. Pousinha, Camilla Giudici, Marc Aurel Busche, Peter Jedlicka, Michael Willem, Hélène Marie

Publikováno v: Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-13 (2021)

Abstract Background Amyloid precursor protein (APP) processing is central to Alzheimer’s disease (AD) etiology. As early cognitive alterations in AD are strongly correlated to abnormal information processing due to increasing synaptic impairment, i

Externí odkaz: https://doaj.org/article/8d3b175cccd54deba4ca41637388c576

IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer’s disease

Autor: Sara Costa-Pereira, Jade Dunot, David Blum, Bruno Silva-Santos, Emilie Faivre, Luísa V. Lopes, Julie C. Ribot, Joana E. Coelho, Hélène Marie, Paula A. Pousinha, Rui Gomes, Miguel Ribeiro, Julie Darrigues, Afonso Antunes de Almeida, Victoria Gomez-Murcia, Luc Buée, Helena C. Brigas, Kevin Carvalho

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2021, 36 (9), pp.109574. ⟨10.1016/j.celrep.2021.109574⟩
Cell Reports, 2021, 36 (9), pp.109574. ⟨10.1016/j.celrep.2021.109574⟩
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
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© 2021 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Neuroinflammation in patients with Alzheimer's disease (AD) and related mouse models has been recognized for decades, bu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4825421007a8884ccb61b87dbe350824
https://hal.archives-ouvertes.fr/hal-03391561