Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jade A. Spencer"'
Autor:
Christopher K. Cote, Kevin D. Mlynek, Christopher P. Klimko, Sergei S. Biryukov, Sherry Mou, Melissa Hunter, Nathaniel O. Rill, Jennifer L. Dankmeyer, Jeremey A. Miller, Yuli Talyansky, Michael L. Davies, J. Matthew Meinig, Stephanie A. Halasohoris, Anette M. Gray, Jade L. Spencer, Ashley L. Babyak, M. Kelly Hourihan, Bobby J. Curry, Ronald G. Toothman, Sara I. Ruiz, Xiankun Zeng, Keersten M. Ricks, Tamara L. Clements, Christina E. Douglas, Suma Ravulapalli, Christopher P. Stefan, Charles J. Shoemaker, Mindy G. Elrod, Jay E. Gee, Zachary P. Weiner, Ju Qiu, Joel A. Bozue, Nancy A. Twenhafel, David DeShazer
Publikováno v:
Emerging Infectious Diseases, Vol 30, Iss 10, Pp 2056-2069 (2024)
In the United States in 2021, an outbreak of 4 cases of Burkholderia pseudomallei, the etiologic agent of melioidosis and a Tier One Select Agent (potential for deliberate misuse and subsequent harm), resulted in 2 deaths. The causative strain, B. ps
Externí odkaz:
https://doaj.org/article/8ea8582aa67e4680aa3494f13afc1315
Autor:
Milene Volpato, John Hutchinson, Catriona Marshall, P. Louise Coletta, Jade A. Spencer, Nicola Ingram, SL Perry, Anna Nicolaou, Paul M. Loadman, Mark A. Hull, Amanda D. Race
Publikováno v:
Nicolaou, A & et al. 2020, ' Cyclooxygenase activity mediates colorectal cancer cell resistance to the omega-3 polyunsaturated fatty acid eicosapentaenoic acid ', Cancer Chemotherapy and Pharmacology . https://doi.org/10.1007/s00280-020-04157-2
Cancer Chemother Pharmacol
Cancer Chemotherapy and Pharmacology
Cancer Chemother Pharmacol
Cancer Chemotherapy and Pharmacology
PurposeThe naturally-occurring omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) is safe, well-tolerated and inexpensive, making it an attractive anti-cancer intervention. However, EPA has only modest anti-colorectal cancer (CRC) activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de86493b213c066d2f4df5e4d849c186
https://doi.org/10.1007/s00280-020-04157-2
https://doi.org/10.1007/s00280-020-04157-2
Autor:
Mark A. Hull, Clare L. Lawton, Louise Dye, Suparna Mitra, Henry Watson, Giles J. Toogood, Fiona Croden, M Taylor, Paul M. Loadman, SL Perry, Henry M. Wood, Phil Quirke, Jade A. Spencer
Publikováno v:
Gut. 67:1974-1983
ObjectiveOmega-3 polyunsaturated fatty acids (PUFAs) have anticolorectal cancer (CRC) activity. The intestinal microbiota has been implicated in colorectal carcinogenesis. Dietary omega-3 PUFAs alter the mouse intestinal microbiome compatible with an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426c0d345aae7a76116f9d7140d9fc5b
https://doi.org/10.1136/gutjnl-2017-314968
https://doi.org/10.1136/gutjnl-2017-314968
Autor:
Bindi S. Brook, Chris Twelves, Matthew E. Hubbard, Maria Jove, Stephen W. Smye, Reuben D. O'Dea, Roger M. Phillips, Elizabeth C. Holden, Paul M. Loadman, Jade A. Spencer
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 370(2)
Adequate drug distribution through tumors is essential for treatment to be effective. Palbociclib is a cyclin-dependent kinase 4/6 inhibitor approved for use in patients with hormone receptor positive, human epidermal growth factor receptor 2 negativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efef7c1e248bb93d6327a68673625626
https://pubmed.ncbi.nlm.nih.gov/31189729
https://pubmed.ncbi.nlm.nih.gov/31189729
Publikováno v:
Critical reviews in oncology/hematology. 141
Failure of systemic cancer treatment can be, at least in part, due to the drug not being delivered to the tumour at sufficiently high concentration and/or sufficiently homogeneous distribution; this is termed as “pharmacokinetic drug resistance”.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ddff216e244498bf447b7554f5d739d
https://pubmed.ncbi.nlm.nih.gov/31302407
https://pubmed.ncbi.nlm.nih.gov/31302407
Autor:
Jade A. Spencer, Paul M. Loadman, Patricia A. Cooper, Chris Twelves, Steven D. Shnyder, Amanda D. Race
Publikováno v:
Cancer Research. 80:4847-4847
Background: Palbociclib is a CDK4/6 inhibitor approved for the treatment of ER+ HER2- advanced/metastatic breast cancer (MBC). We explored the hypothesis that palbociclib can enhance the efficacy of cytotoxics by synchronising the cell cycle prior to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbad6c4298e3c86c8796f70151002dde
https://doi.org/10.1158/1538-7445.am2020-4847
https://doi.org/10.1158/1538-7445.am2020-4847
A liquid chromatography-tandem mass spectrometry method to measure fatty acids in biological samples
Autor:
Milene Volpato, Mark A. Hull, Alessandra Munarini, Andrew J. Cockbain, Jade A. Spencer, Andrea Belluzzi, Amanda D. Race, Paul M. Loadman
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
As pre-clinical and clinical research interest in ω-3 polyunsaturated fatty acids (PUFA) increases, so does the need for a fast, accurate and reproducible analytical method to measure fatty acids (FA) in biological samples in order to validate poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a46e26ddf201bd13aad3e790535ccc4d
https://pubmed.ncbi.nlm.nih.gov/28467947
https://pubmed.ncbi.nlm.nih.gov/28467947
Autor:
Milene Volpato, Henry Watson, Jade A. Spencer, Andrew J. Cockbain, Paul M. Loadman, Amanda D. Race, Mark A. Hull, Giles J. Toogood
Publikováno v:
Prostaglandins, leukotrienes, and essential fatty acids. 115
We investigated red blood cell (RBC) PUFA profiles, and the predictive value of RBC EPA content for tumour EPA exposure and clinical outcomes, in the EMT study, a randomised trial of EPA in patients awaiting colorectal cancer (CRC) liver metastasis s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34b66f6d493d4288fc043be0cda63185
https://pubmed.ncbi.nlm.nih.gov/27914515
https://pubmed.ncbi.nlm.nih.gov/27914515
Autor:
Malcolm R. Clench, Cristina Russo, Paul M. Loadman, Patricia A. Cooper, Ramon Salazar, Maria Jove Casulleras, Steve D. Shnyder, Chris J Twelves, Amanda D. Race, Jade A. Spencer
Publikováno v:
Cancer Research. 78:4926-4926
Background: Eri & Cap are active as single agents in metastatic breast cancer, but the combination appears particularly active & well tolerated clinically. We explored the hypothesis that normalisation of tumor vasculature by Eri seen in preclinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48d4709045d23d4fd5e81be7ffe81d53
https://doi.org/10.1158/1538-7445.am2018-4926
https://doi.org/10.1158/1538-7445.am2018-4926
Autor:
Paul M. Loadman, Maria Jove, Amanda D. Race, Lava Sulayman, Chris Twelves, Jo Wicks, Jade A. Spencer
Publikováno v:
Cancer Research. 77:4205-4205
Introduction: Pre-clinical drug development does not routinely assess drug penetration beyond use of the human intestinal Caco-2 cell line as an in vitro model of the intestinal barrier to evaluate potential drug absorption. Detailed in vivo tumour p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55f26621d436a8bcfecba4f0715ca52d
https://doi.org/10.1158/1538-7445.am2017-4205
https://doi.org/10.1158/1538-7445.am2017-4205