Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jada H. Vaden"'
Autor:
Jessica M. Froula, Benjamin W. Henderson, Jose Carlos Gonzalez, Jada H. Vaden, John W. Mclean, Yumei Wu, Gokulakrishna Banumurthy, Linda Overstreet-Wadiche, Jeremy H. Herskowitz, Laura A. Volpicelli-Daley
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-13 (2018)
Abstract Neuronal inclusions composed of α-synuclein (α-syn) characterize Parkinson’s Disease (PD) and Dementia with Lewy bodies (DLB). Cognitive dysfunction defines DLB, and up to 80% of PD patients develop dementia. α-Syn inclusions are abunda
Externí odkaz:
https://doaj.org/article/ba926feb28c449fa93eef0a3491c5679
Autor:
Jennifer A Watson, Bula J Bhattacharyya, Jada H Vaden, Julie A Wilson, Mert Icyuz, Alan D Howard, Edward Phillips, Tara M DeSilva, Gene P Siegal, Andrew J Bean, Gwendalyn D King, Scott E Phillips, Richard J Miller, Scott M Wilson
Publikováno v:
PLoS Genetics, Vol 11, Iss 6, p e1005290 (2015)
Neurons are particularly vulnerable to perturbations in endo-lysosomal transport, as several neurological disorders are caused by a primary deficit in this pathway. In this report, we used positional cloning to show that the spontaneously occurring n
Externí odkaz:
https://doaj.org/article/4fa74ad0928c45cbb6f41a27408027a2
Autor:
Jada H Vaden, Jennifer Ashley Watson, Alan David Howard, Ping-Chung eChen, Julie Ann Wilson, Scott Michael Wilson
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 8 (2015)
Ubiquitin-specific protease 14 (USP14) is a major deubiquitinating enzyme and a key determinant of neuromuscular junction (NMJ) structure and function. We have previously reported dramatic ubiquitin depletion in the nervous systems of the USP14-defic
Externí odkaz:
https://doaj.org/article/ebdeb4a68bef493f87613d8a88d417d1
Publikováno v:
Journal of Neurochemistry. 148:386-399
Ubiquitin is an essential signaling protein that controls many different cellular processes. While cellular ubiquitin levels normally cycle between pools of free and conjugated ubiquitin, the balance of these ubiquitin pools can be shifted by exposur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::261cc3b0de04d160b4ab7f263be113bd
https://doi.org/10.1111/jnc.14630
https://doi.org/10.1111/jnc.14630
Autor:
Linda Overstreet-Wadiche, Izumi Sugihara, Jacques I. Wadiche, Gokulakrishna Banumurthy, Shreya Malhotra, Jada H. Vaden, Reagan L. Pennock
Publikováno v:
J Neurosci
Neurotransmitter spillover is a form of communication not readily predicted by anatomical structure. In the cerebellum, glutamate spillover from climbing fibers recruits molecular layer interneurons in the absence of conventional synaptic connections
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0c4e3f8ded952ca11d36e997e22b5c5
https://pubmed.ncbi.nlm.nih.gov/34400517
https://pubmed.ncbi.nlm.nih.gov/34400517
Autor:
Jeremy H. Herskowitz, Benjamin W. Henderson, Jada H. Vaden, Laura A. Volpicelli-Daley, Gokulakrishna Banumurthy, Linda Overstreet-Wadiche, Yumei Wu, John W. Mclean, Jessica M. Froula, Jose Carlos Gonzalez
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-13 (2018)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Neuronal inclusions composed of α-synuclein (α-syn) characterize Parkinson’s Disease (PD) and Dementia with Lewy bodies (DLB). Cognitive dysfunction defines DLB, and up to 80% of PD patients develop dementia. α-Syn inclusions are abundant in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::badac168f5f5beca278633e5fe7a1817
http://link.springer.com/article/10.1186/s40478-018-0537-x
http://link.springer.com/article/10.1186/s40478-018-0537-x
Autor:
Linda Overstreet-Wadiche, Gokulakrishna Banumurthy, Jada H. Vaden, Jacques I. Wadiche, E. S. Gusarevich
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
The number of neurotransmitter-filled vesicles released into the synaptic cleft with each action potential dictates the reliability of synaptic transmission. Variability of this fundamental property provides diversity of synaptic function across brai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaecac145cbeb2f5a4dab525198b343e
https://elifesciences.org/articles/47434
https://elifesciences.org/articles/47434
Autor:
Jada H. Vaden, Jacques I. Wadiche, Luke T. Coddington, Angela K. Nietz, Linda Overstreet-Wadiche
Publikováno v:
eLife
eLife, Vol 6 (2017)
eLife, Vol 6 (2017)
Golgi cells are the principal inhibitory neurons at the input stage of the cerebellum, providing feedforward and feedback inhibition through mossy fiber and parallel fiber synapses. In vivo studies have shown that Golgi cell activity is regulated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e769b1589928af17860187dddd88f3
http://europepmc.org/articles/PMC5640426
http://europepmc.org/articles/PMC5640426