Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jad Maamary"'
Autor:
David Prihoda, Jad Maamary, Andrew Waight, Veronica Juan, Laurence Fayadat-Dilman, Daniel Svozil, Danny A. Bitton
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Despite recent advances in transgenic animal models and display technologies, humanization of mouse sequences remains one of the main routes for therapeutic antibody development. Traditionally, humanization is manual, laborious, and requires expert k
Externí odkaz:
https://doaj.org/article/1cfab3de8e254294ae2cd13c6a106121
Autor:
Liset Westera, Alisha M. Jennings, Jad Maamary, Martin Schwemmle, Adolfo García-Sastre, Eric Bortz
Publikováno v:
Advances in Virology, Vol 2019 (2019)
Influenza A viruses (IAV) are evolutionarily successful pathogens, capable of infecting a number of avian and mammalian species and responsible for pandemic and seasonal epidemic disease in humans. To infect new species, IAV typically must overcome a
Externí odkaz:
https://doaj.org/article/25d1b56894b3449da49101ba5ddac054
Autor:
Mila Brum Ortigoza, Oliver Dibben, Jad Maamary, Luis Martinez-Gil, Victor H Leyva-Grado, Pablo Abreu, Juan Ayllon, Peter Palese, Megan L Shaw
Publikováno v:
PLoS Pathogens, Vol 8, Iss 4, p e1002668 (2012)
Influenza viruses continue to pose a major public health threat worldwide and options for antiviral therapy are limited by the emergence of drug-resistant virus strains. The antiviral cytokine, interferon (IFN) is an essential mediator of the innate
Externí odkaz:
https://doaj.org/article/2658e6b4c2e042d0aa9be6c8b270cfdb
Autor:
Eric Bortz, Liset Westera, Jad Maamary, John Steel, Randy A. Albrecht, Balaji Manicassamy, Geoffrey Chase, Luis Martínez-Sobrido, Martin Schwemmle, Adolfo García-Sastre
Publikováno v:
mBio, Vol 2, Iss 4 (2011)
ABSTRACT Highly pathogenic avian influenza A (HPAI) viruses of the H5N1 subtype have recently emerged from avian zoonotic reservoirs to cause fatal human disease. Adaptation of HPAI virus RNA-dependent RNA polymerase (PB1, PB2, and PA proteins) and n
Externí odkaz:
https://doaj.org/article/ca34bbf134f14f6dabe7f0d60ab0c2a6
Publikováno v:
Journal of pharmaceutical sciences. 111(4)
Immunogenicity to biologics is often observed following dosing in human subjects during clinical trials. Both product and host specific factors may be implicated in contributing to a potential immune response. However, even if such risk factors are i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3689a930fa23949e121b0691594f3af4
https://pubmed.ncbi.nlm.nih.gov/35122828
https://pubmed.ncbi.nlm.nih.gov/35122828
Autor:
Martin Schwemmle, Alisha M. Jennings, Jad Maamary, Eric Bortz, Adolfo García-Sastre, Liset Westera
Publikováno v:
Advances in Virology
Advances in Virology, Vol 2019 (2019)
Advances in Virology, Vol 2019 (2019)
Influenza A viruses (IAV) are evolutionarily successful pathogens, capable of infecting a number of avian and mammalian species, and responsible for pandemic and seasonal epidemic disease in humans. To infect new species, IAV typically must overcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acae3fedc7a0ec3a93bfb8b70182d26f
http://europepmc.org/articles/PMC6444269
http://europepmc.org/articles/PMC6444269
Autor:
Florian Krammer, Peter Palese, Sarah J. Schlesinger, Gene S. Tan, Jeffrey V. Ravetch, Taia T. Wang, Rafi Ahmed, Carl W. Davis, Jad Maamary, Stylianos Bournazos
Publikováno v:
Cell. 162(1):160-169
SummaryProtective vaccines elicit high-affinity, neutralizing antibodies by selection of somatically hypermutated B cell antigen receptors (BCR) on immune complexes (ICs). This implicates Fc-Fc receptor (FcR) interactions in affinity maturation, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d1d041371ebcb934da8d9e6af0490d3
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(38)
The main barrier to reduction of morbidity caused by influenza is the absence of a vaccine that elicits broad protection against different virus strains. Studies in preclinical models of influenza virus infections have shown that antibodies alone are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ebed62eba1e3de1e7d27351cd31c60b
https://pubmed.ncbi.nlm.nih.gov/28874545
https://pubmed.ncbi.nlm.nih.gov/28874545
IgG antibodies mediate a diversity of immune functions by coupling of antigen specificity through the Fab domain to signal transduction via Fc-Fc receptor interactions. Indeed, balanced IgG signaling through type I and type II Fc receptors is require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b91e29ecbc7fcdef1654dc06061ffb9a
https://europepmc.org/articles/PMC5613280/
https://europepmc.org/articles/PMC5613280/
Autor:
Dabeiba Bernal-Rubio, Jad Maamary, Juan R. Rodriguez-Madoz, Alan Belicha-Villanueva, Alina Baum, Maria Minguito de la Escalera, Ana Fernandez-Sesma, Adolfo García-Sastre
Publikováno v:
Journal of Virology. 86:5926-5930
Influenza A viruses containing the promoter mutations G3A/C8U in a given segment express increased levels of the corresponding viral protein during infection due to increased levels of mRNA or cRNA species. The replication of these recombinant viruse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05bf1817b1c05c9983fe26c5871c27dc
https://doi.org/10.1128/jvi.06384-11
https://doi.org/10.1128/jvi.06384-11