Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jacy R. Crosby"'
Autor:
Vivien A Sheehan, Jacy R Crosby, Aniko Sabo, Nicole A Mortier, Thad A Howard, Donna M Muzny, Shannon Dugan-Perez, Banu Aygun, Kerri A Nottage, Eric Boerwinkle, Richard A Gibbs, Russell E Ware, Jonathan M Flanagan
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110740 (2014)
Hydroxyurea has proven efficacy in children and adults with sickle cell anemia (SCA), but with considerable inter-individual variability in the amount of fetal hemoglobin (HbF) produced. Sibling and twin studies indicate that some of that drug respon
Externí odkaz:
https://doaj.org/article/92b9698c6a9b4d21be5ddfd8aef760dd
Autor:
Alireza Paikari, Carly C. Ginter Summarell, Jacy R. Crosby, Pavel Sumazin, Yankai Zhang, Eric Boerwinkle, Vivien A. Sheehan, Mitchell J. Weiss
Publikováno v:
Blood. 132:321-333
Induction of red blood cell (RBC) fetal hemoglobin (HbF; α2γ2) ameliorates the pathophysiology of sickle cell disease (SCD) by reducing the concentration of sickle hemoglobin (HbS; α2β(S)2) to inhibit its polymerization. Hydroxyurea (HU), the onl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292a45c8d366fc7b0dae12adad3d70f3
https://doi.org/10.1182/blood-2017-11-814335
https://doi.org/10.1182/blood-2017-11-814335
Autor:
Wensheng Sun, David Couper, Jennifer Jiang, Ron C. Hoogeveen, Salim S. Virani, Christie M. Ballantyne, Rhiannon Dodge, Jacy R Crosby, John W. Gaubatz, Eric Boerwinkle, Sekar Kathiresan
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 34:1069-1077
Objective— To investigate the relationship between plasma levels of small dense low-density lipoprotein-cholesterol (sdLDL-C) and risk for incident coronary heart disease (CHD) in a prospective study among Atherosclerosis Risk in Communities (ARIC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c64624ca61deb8f212f1bd649ec79dc8
https://doi.org/10.1161/atvbaha.114.303284
https://doi.org/10.1161/atvbaha.114.303284
Autor:
Albert Hofman, Megan L. Grove, Jennifer A. Brody, Adolfo Correa, Kim Lawson, Jose M. Ordovas, Yingchang Lu, André G. Uitterlinden, Riccardo E. Marioni, Nathan O. Stitziel, Oscar H. Franco, Yongmei Liu, Ingrid B. Borecki, Aron Y. Joon, Lindsay M. Reynolds, Ozren Polasek, Kelli K. Ryckman, Muredach P. Reilly, Johanna Jakobsdottir, Abbas Dehghan, L. Adrienne Cupples, Tamara B. Harris, Michael Griswold, Judy Wang, Christopher S. Carlson, Caroline Hayward, Leslie A. Lange, Stephen S. Rich, Kenneth Rice, Jacy R Crosby, Diego Ardissino, Charles Kooperberg, Gudny Eiriksdottir, Rachel H. Mackey, Ani Manichaikul, Martin Farrall, Jennifer E. Huffman, Albert V. Smith, Vilmundur Gudnason, Aniruddh P. Patel, Ruth J. F. Loos, Sumeet A. Khetarpal, Daniel J. Rader, Domenico Girelli, Eric Boerwinkle, Qunyuan Zhang, Valeska Redon, Anuj Goel, Cornelia M. van Duijn, Bruce M. Psaty, Ruth McPherson, Piera Angelica Merlini, Daniel Levy, Ian J. Deary, Christopher J. O'Donnell, Kurt Lohman, Josyf C. Mychaleckyj, Brian W. Davis, Mary F. Feitosa, Kent D. Taylor, James S. Pankow, Marju Orho-Melander, Alanna C. Morrison, Igor Rudan, Alexander P. Reiner, William E. Kraus, Ulrike Peters, Paul L. Auer, Paolo Zanoni, Svati H. Shah, Olle Melander, Jennifer G. Robinson, Joshua C. Bis, Erwin P. Bottinger, Mingyao Li, George Hindy, Omri Gottesman, Stefano Duga, Herman A. Taylor, Y.-D. Ida Chen, David S. Siscovick, Aaron Isaacs, Michael Y. Tsai, Sekar Kathiresan, James G. Wilson, Pamela J. Schreiner, Nicola Martinelli, Myriam Fornage, Serkalem Demissie, Lenore J. Launer, Hugh Watkins, Arend Voorman, Jerome I. Rotter, Jeanette M. Stafford, John M. Starr, Gina M. Peloso, Rosanna Asselta, Gail Davies, Rebecca D. Jackson
Publikováno v:
American Journal of Human Genetics, 94(2), 223-232. Cell Press
American Journal of Human Genetics, 94(2), 223-32. Cell Press
American Journal of Human Genetics, 94(2), 223-32. Cell Press
Low-frequency coding DNA sequence variants in the proprotein convertase subtilisin/kexin type 9 gene (PCSK9) lower plasma low-density lipoprotein cholesterol (LDL-C), protect against risk of coronary heart disease (CHD), and have prompted the develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e58bcf3c1a5b72ab8d097dcaa1bd728d
https://doi.org/10.1016/j.ajhg.2014.01.009
https://doi.org/10.1016/j.ajhg.2014.01.009
Autor:
Pali Sen, Jacy R. Crosby
Publikováno v:
American Journal of Mathematics and Statistics. 2:129-138
When performing analysis of individual data on the application of a particu lar drug, it is useful to study the within variability. But when two drugs are used in combination, it is of more interest to study any combination effects on the subjects. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::975901f50f4113a2a72753c95bac9865
https://doi.org/10.5923/j.ajms.20120205.05
https://doi.org/10.5923/j.ajms.20120205.05
Autor:
Jacy R Crosby, Lora Lewis, Humeira Akbar, Yasunari Sakai, Huda Y. Zoghbi, Christian P. Schaaf, Donna M. Muzny, Eric Boerwinkle, Alicia Hawes, Aniko Sabo, Richard A. Gibbs, Robin T. Varghese
Publikováno v:
Human Molecular Genetics
Autism spectrum disorders (ASDs) are a heterogeneous group of neuro-developmental disorders. While significant progress has been made in the identification of genes and copy number variants associated with syndromic autism, little is known to date ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9539511ccb7c19a4b81bb2ddea56177
https://doi.org/10.1093/hmg/ddr243
https://doi.org/10.1093/hmg/ddr243
Autor:
Hong-Hee Won, Zi Ye, Danish Saleheen, Zheng-Zheng Tang, Rebecca D. Jackson, Pierre Fontanillas, Leslie A. Lange, Sharon Cresci, Julie E. Buring, Heribert Schunkert, Lisa Bastarache, Erin Austin, Nicola Marziliano, Stacey Gabriel, Piera Angelica Merlini, Peter Weeke, Paul M. Ridker, Inke R. König, Namrata Gupta, Anuj Goel, Karl-Ludwig Laugwitz, Maria Francesca Notarangelo, G. Kees Hovingh, Joshua C. Denny, Stefano Duga, Christian M. Shaffer, Gonçalo R. Abecasis, Muredach P. Reilly, Dan M. Roden, Colin N. A. Palmer, Jacy R Crosby, Daniel J. Rader, Thomas Meitinger, John Danesh, Sekar Kathiresan, Panos Deloukas, Eric Boerwinkle, James G. Wilson, Nathan O. Stitziel, Hugh Watkins, Diego Ardissino, Themistocles L. Assimes, Eric S. Lander, Paul L. Auer, Alanna C. Morrison, Martin Farrall, Christopher J. O'Donnell, Stephen M. Schwartz, Rosanna Asselta, Russell P. Tracy, Deborah A. Nickerson, Ruth McPherson, Christie M. Ballantyne, Shamil R. Sunyaev, Jerome I. Rotter, Daniel I. Chasman, Alexander P. Reiner, Ron Do, David S. Siscovick, Gina M. Peloso, Richard A. Gibbs, Donna M. Muzny, David Altshuler, Stanley L. Hazen, Danyu Lin, Thorsten Kessler, Jeanette Erdmann, Pradeep Natarajan, Iftikhar J. Kullo, Ursula M. Schick, Paola G. Ferrario, Adnan Kastrati, Robert L. Wilensky, Stephen S. Rich, Jaume Marrugat, Roberto Elosua, John A. Spertus
Publikováno v:
The New England journal of medicine, vol 371, iss 22
PMC
New England journal of medicine, 371(22), 2072-2082. Massachussetts Medical Society
PMC
New England journal of medicine, 371(22), 2072-2082. Massachussetts Medical Society
Background Ezetimibe lowers plasma levels of low-density lipoprotein (LDL) cholesterol by inhibiting the activity of the Niemann–Pick C1-like 1 (NPC1L1) protein. However, whether such inhibition reduces the risk of coronary heart disease is not kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b37fa5cd866642cfb55fd48687c724b9
https://escholarship.org/uc/item/06w7q4j8
https://escholarship.org/uc/item/06w7q4j8
Autor:
Stavroula Kanoni, Olle Melander, He Zhang, Omri Gottesman, Yingchang Lu, Nathan O. Stitziel, Caroline S. Fox, Stephen S. Rich, Ruth J. F. Loos, Jochen Kruppa, Bruce M. Psaty, Kathleen Stirrups, Jose M. Ordovas, Nora Franceschini, Majid Nikpay, Christie M. Ballantyne, Gonçalo R. Abecasis, Natalie R. van Zuydam, Dermot F. Reilly, Werner Koch, Kari E. North, George Hindy, Jacy R Crosby, Deborah N. Farlow, Nicholas G. D. Masca, Chenyi Xue, Leslie A. Lange, David R. Crosslin, Lisa W. Martin, Paul L. Auer, Oliviero Olivieri, Domenico Girelli, Russell P. Tracy, David Altshuler, Nicola Martinelli, Cristen J. Willer, Ron Do, Heribert Schunkert, Oddgeir L. Holmen, Gina M. Peloso, Sekar Kathiresan, James G. Wilson, Hyun Min Kang, Pier Angelica Merlini, Stefano Duga, Charles Kooperberg, Zheng-Zheng Tang, Gail P. Jarvik, Anuj Goel, Kristian Hveem, Alistair S. Hall, Thomas Meitinger, Marju Orho-Melander, Diego Ardissino, Themistocles L. Assimes, Rosanna Asselta, Elizabeth K. Speliotes, Franziska Degenhardt, Colin N. A. Palmer, Goo Jun, Youna Hu, Martin Farrall, Ruth McPherson, Stefan A. Escher, Mark A. DePristo, Namrata Gupta, Nicholas J. Wareham, L. Adrienne Cupples, Annette Peters, Danyu Lin, Raimund Erbel, Wu Yin, Jan-Håkan Jansson, Wolfgang Lieb, Hugh Watkins, Stacey Gabriel, Nilesh J. Samani, Inke R. König, Jennifer G. Robinson, Erwin P. Bottinger, Deborah A. Nickerson, Jeanette Erdmann, Christopher J. O'Donnell, Panos Deloukas, Eric Boerwinkle, Alexander P. Reiner
Publikováno v:
N. Engl. J. Med. 371, 22-31 (2014)
New England Journal of Medicine; 371(1), pp 22-31 (2014)
New England Journal of Medicine; 371(1), pp 22-31 (2014)
Background Plasma triglyceride levels are heritable and are correlated with the risk of coronary heart disease. Sequencing of the protein-coding regions of the human genome (the exome) has the potential to identify rare mutations that have a large ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08cc2ae3e1e279c804fc9411a32742df
https://www.ncbi.nlm.nih.gov/pubmed/24941081
https://www.ncbi.nlm.nih.gov/pubmed/24941081
Publikováno v:
Blood. 126:282-282
Sickle cell disease (SCD) affects >100,000 Americans and millions more worldwide. Symptoms and sequelae of SCD can be ameliorated by increasing fetal hemoglobin (HbF, α2γ2) levels. Unfortunately, up to 50% of adult SCD patients treated with hydroxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3705016b1dd512ca3b6130f929a55b2
https://doi.org/10.1182/blood.v126.23.282.282
https://doi.org/10.1182/blood.v126.23.282.282
Autor:
Richard A. Gibbs, Jonathan M. Flanagan, Eric Boerwinkle, Russell E. Ware, Donna M. Muzny, Nicole A. Mortier, Kerri Nottage, Vivien A. Sheehan, Jacy R Crosby, Thad A. Howard, Shannon Dugan-Perez, Aniko Sabo, Banu Aygun
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 10, p e110740 (2014)
PLoS ONE, Vol 9, Iss 10, p e110740 (2014)
Hydroxyurea has proven efficacy in children and adults with sickle cell anemia (SCA), but with considerable inter-individual variability in the amount of fetal hemoglobin (HbF) produced. Sibling and twin studies indicate that some of that drug respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::833ff3582cde82941d29dedee048342f
https://doi.org/10.1371/journal.pone.0110740
https://doi.org/10.1371/journal.pone.0110740