Genetic loci influencing kidney function and chronic kidney disease

Autor: Thomas Eggermann, James Scott, Graham M. Lord, L.J. Ubink-Veltmaat, Weihua Zhang, Gérard Waeber, Georg Schlieper, Michael J.E. Sternberg, Brenda W.J.H. Penninx, Stephan J. L. Bakker, Elina Hyppönen, Toshiko Tanaka, Bo Hedblad, Xijin Han, Peter Vollenweider, Johannes H. Smit, Anneli Pouta, Yun Li, Olle Melander, Nita G. Forouhi, Morris J. Brown, Joban Sehmi, George Davey Smith, Ruth J. F. Loos, Vincent Mooser, Jaap J. Homan van der Heide, Manuela Uda, Mark N. Wass, Debbie A Lawlor, Gonçalo R. Abecasis, Klaus Zerres, Nicole Soranzo, Leena Peltonen, Maria P. Hernandez-Fuentes, Marketa Sjögren, Dawn M. Waterworth, Ron T. Gansevoort, Mark J. Caulfield, Nada Dimkovic, Shah Ebrahim, Louise Nordfors, Harold Snieder, Ranil de Silva, Céline Maréchal, Olivier Devuyst, Ioana Cotlarciuc, Toby Johnson, John M. C. Connell, Jian'an Luan, Martin Schalling, R. Swaminathan, Peter Stenvinkel, Nanne Kleefstra, Henk J. G. Bilo, Guohong Deng, Patrick H. Maxwell, Bouke G. Hepkema, Inga Prokopenko, Karin Luttropp, Luigi Ferrucci, Murielle Bochud, Gerjan Navis, Kourosh R. Ahmadi, Anna F. Dominiczak, Paul Elliott, H. Terence Cook, Serena Sanna, Mark Dockrell, Chris Wallace, Marc A. Seelen, Esperanza Perucha, Marta Lapsley, Marjo-Riitta Järvelin, Jürgen Floege, David Schlessinger, Afshin Parsa, Vasiliki Lagou, Liz Lightstone, Patricia B. Munroe, Daniel P. Gale, Paul E. de Jong, John C. Chambers, Martin Farrall, Tim D. Spector, Alan R. Shuldiner, Pim van der Harst, Mark I. McCarthy, Jacqui Beckmann, Lambert D Dikkeschei, Nilesh J. Samani, Paul Roderick, Jaspal S. Kooner, Aimo Ruokonen, Nicholas J. Wareham

Publikováno v: Nature Genetics, 42(5), 373-375. Nature Publishing Group
Chambers, J C, Zhang, W H, Lord, G M, van der Harst, P, Lawlor, D A, Sehmi, J S, Gale, D P, Wass, M N, Ahmadi, K R, Bakker, J L, Beckmann, J, Bilo, H J G, Bochud, M, Brown, M J, Caulfield, M J, Connell, J M C, Cook, H T, Cotlarciuc, I, Smith, G D, de Silva, R, Deng, G H, Devuyst, O, Dikkeschei, L D, Dimkovic, N, Dockrell, M, Dominiczak, A, Ebrahim, S, Eggermann, T, Farrall, M, Ferrucci, L, Floege, J, Forouhi, N G, Gansevoort, R T, Han, X J, Hedblad, B, van der Heide, J J H, Hepkema, B G, Hernandez-Fuentes, M, Hypponen, E, Johnson, T, de Jong, P E, Kleefstra, N, Lagou, V, Lapsley, M, Li, Y, Loos, R J F, Luan, J, Luttropp, K, Marechal, C, Melander, O, Munroe, P B, Nordfors, L, Parsa, A, Peltonen, L, Penninx, B W J H, Perucha, E, Pouta, A, Prokopenko, I, Roderick, P J, Ruokonen, A, Samani, N J, Sanna, S, Schalling, M, Schlessinger, D, Schlieper, G, Seelen, M A J, Shuldiner, A R, Sjogren, M, Smit, J H, Snieder, H, Soranzo, N, Spector, T D, Stenvinkel, P, Sternberg, M J E, Swaminathan, R, Tanaka, T, Ubink-Veltmaat, L J, Uda, M, Vollenweider, P, Wallace, C, Waterworth, D, Zerres, K, Waeber, G, Wareham, N J, Maxwell, P H, McCarthy, M I, Jarvelin, M R, Mooser, V, Abecasis, G R, Lightstone, L, Scott, J, Navis, G, Elliott, P & Kooner, J S 2010, ' Genetic loci influencing kidney function and chronic kidney disease ', Nature Genetics, vol. 42, no. 5, pp. 373-375 . https://doi.org/10.1038/ng.566
Nature genetics, 42(5), 373-375. Nature Publishing Group
Nature Genetics, 42(5), 373-375
Nature Genetics
Nature genetics
Nature Genetics; Vol 42

Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10−10 to 10−15). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A

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https://research.vumc.nl/en/publications/9a3e1424-986d-4779-babc-c9ea12333200