Výsledky vyhledávání - "Jacquetta M, Trasler"

Akademický článek

Sperm DNA methylome abnormalities occur both pre- and post-treatment in men with Hodgkin disease and testicular cancer

Autor: Donovan Chan, Kathleen Oros Klein, Antoni Riera-Escamilla, Csilla Krausz, Cristian O’Flaherty, Peter Chan, Bernard Robaire, Jacquetta M. Trasler

Publikováno v: Clinical Epigenetics, Vol 15, Iss 1, Pp 1-19 (2023)

Abstract Background Combination chemotherapy has contributed to increased survival from Hodgkin disease (HD) and testicular cancer (TC). However, questions concerning the quality of spermatozoa after treatment have arisen. While studies have shown ev

Externí odkaz: https://doaj.org/article/ee283cdeca094d42b57e7edecd141171

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Akademický článek

Exposure to environmental contaminants and folic acid supplementation intergenerationally impact fetal skeleton development through the paternal lineage in a rat model

Autor: Phanie L. Charest, Emmanuel Tessougue, Maryse Lessard, Pauline M. Herst, Pauline Navarro, Sarah Kimmins, Jacquetta M. Trasler, Amanda J. MacFarlane, Marie-Odile Benoit-Biancamano, Janice L. Bailey, Mathieu Dalvai

Publikováno v: Frontiers in Toxicology, Vol 4 (2022)

Persistent organic pollutants (POPs) are ubiquitous in the environment, which is of concern since they are broadly toxic for wildlife and human health. It is generally accepted that maternal prenatal folic acid supplementation (FA) may beneficially i

Externí odkaz: https://doaj.org/article/ac93d9bb901d408db719e6ba132b7668

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5,10-Methylenetetrahydrofolate reductase becomes phosphorylated during meiotic maturation in mouse oocytes

Autor: Kyla Young, Allison K. Tscherner, Baohua Zhang, Megan Meredith, Taylor McClatchie, Jacquetta M. Trasler, Jay M. Baltz

Publikováno v: Zygote. 30:674-688

SummaryThe enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) links the folate cycle that produces one-carbon units with the methionine cycle that converts these into S-adenosylmethionine (SAM), the universal methyl donor for almost all methyltr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a47e866a840bb42dff0c8e8feed602c
https://doi.org/10.1017/s0967199422000156

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Paternal MTHFR deficiency leads to hypomethylation of young retrotransposons and reproductive decline across two successive generations

Autor: Gurbet Karahan, Kenjiro Shirane, Jay M. Baltz, Matthew C. Lorincz, Taylor McClatchie, Sanne M. Janssen, Jacquetta M. Trasler, Donovan Chan

Publikováno v: Development (Cambridge, England)
article-version (VoR) Version of Record

5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in the folate metabolic pathway with a key role in generating methyl groups. As MTHFR deficiency impacts male fertility and sperm DNA methylation, there is the potential for epimuta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0c3b783c67ef5dfe7337c62b41c51f
http://europepmc.org/articles/PMC8276981

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Early-Life Exposure to Environmental Contaminants Perturbs the Sperm Epigenome and Induces Negative Pregnancy Outcomes for Three Generations via the Paternal Lineage

Autor: Nancy Côté, Serge McGraw, Ayelet Ziv-Gal, Donovan Chan, Jacquetta M. Trasler, Sarah Kimmins, Astrid Deschênes, Janice L. Bailey, Mathieu Dalvai, Marie-Pier Scott-Boyer, Clotilde Maurice, Arnaud Droit, Jodi A. Flaws, Romain Lambrot

Publikováno v: Epigenomes
Volume 5
Issue 2
Epigenomes, Vol 5, Iss 10, p 10 (2021)

Due to the grasshopper effect, the Arctic food chain in Canada is contaminated with persistent organic pollutants (POPs) of industrial origin, including polychlorinated biphenyls and organochlorine pesticides. Exposure to POPs may be a contributor to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d3e7ad695d411cf8bcfadf7fbec5af

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Akademický článek

Loss of DNMT1o disrupts imprinted X chromosome inactivation and accentuates placental defects in females.

Autor: Serge McGraw, Christopher C Oakes, Josée Martel, M Cecilia Cirio, Pauline de Zeeuw, Winifred Mak, Christoph Plass, Marisa S Bartolomei, J Richard Chaillet, Jacquetta M Trasler

Publikováno v: PLoS Genetics, Vol 9, Iss 11, p e1003873 (2013)

The maintenance of key germline derived DNA methylation patterns during preimplantation development depends on stores of DNA cytosine methyltransferase-1o (DNMT1o) provided by the oocyte. Dnmt1o(mat-/-) mouse embryos born to Dnmt1(Δ1o/Δ1o) female m

Externí odkaz: https://doaj.org/article/fcd229fc7143439d9c7283774ba18045

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Whole-genome sequencing of H3K4me3 and DNA methylation in human sperm reveals regions of overlap linked to fertility and development

Autor: Guillaume Bourque, Mahmoud Aarabi, Tony Kwan, Xiaojian Shao, Sergey I. Moskovtsev, Sarah Kimmins, Jacquetta M. Trasler, Romain Lambrot, Clifford Librach, Donovan Chan, Vanessa Dumeaux

Publikováno v: Cell reports. 36(3)

The paternal environment has been linked to infertility and negative outcomes. Such effects may be transmitted via sperm through histone modifications. To date, in-depth profiling of the sperm chromatin in men has been limited. Here, we use deep sequ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278cdaa73f3f98d713b30d013527bc1e
https://pubmed.ncbi.nlm.nih.gov/34289352

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