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A Deep Learning Approach Validates Genetic Risk Factors for Late Toxicity After Prostate Cancer Radiotherapy in a REQUITE Multi-National Cohort.

Autor: Massi MC; Modelling and Scientific Computing Laboratory, Math Department, Politecnico di Milano, Milan, Italy.; Center for Analysis, Decisions and Society, Human Technopole, Milan, Italy., Gasperoni F; Medical Research Council-Biostatistic Unit, University of Cambridge, Cambridge, United Kingdom., Ieva F; Modelling and Scientific Computing Laboratory, Math Department, Politecnico di Milano, Milan, Italy.; Center for Analysis, Decisions and Society, Human Technopole, Milan, Italy.; CHRP-National Center for Healthcare Research and Pharmacoepidemiology, University of Milano-Bicocca, Milan, Italy., Paganoni AM; Modelling and Scientific Computing Laboratory, Math Department, Politecnico di Milano, Milan, Italy.; Center for Analysis, Decisions and Society, Human Technopole, Milan, Italy.; CHRP-National Center for Healthcare Research and Pharmacoepidemiology, University of Milano-Bicocca, Milan, Italy., Zunino P; Modelling and Scientific Computing Laboratory, Math Department, Politecnico di Milano, Milan, Italy., Manzoni A; Modelling and Scientific Computing Laboratory, Math Department, Politecnico di Milano, Milan, Italy., Franco NR; Modelling and Scientific Computing Laboratory, Math Department, Politecnico di Milano, Milan, Italy., Veldeman L; Department of Human Structure and Repair, Ghent University, Ghent, Belgium.; Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium., Ost P; Department of Human Structure and Repair, Ghent University, Ghent, Belgium.; Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium., Fonteyne V; Department of Human Structure and Repair, Ghent University, Ghent, Belgium.; Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium., Talbot CJ; Leicester Cancer Research Centre, Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom., Rattay T; Leicester Cancer Research Centre, Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom., Webb A; Leicester Cancer Research Centre, Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom., Symonds PR; Leicester Cancer Research Centre, Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom., Johnson K; Leicester Cancer Research Centre, Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom., Lambrecht M; Department of Radiation Oncology, University Hospitals Leuven, Leuven, Belgium., Haustermans K; Department of Radiation Oncology, University Hospitals Leuven, Leuven, Belgium., De Meerleer G; Department of Radiation Oncology, University Hospitals Leuven, Leuven, Belgium., de Ruysscher D; Maastricht University Medical Center, Maastricht, Netherlands.; Department of Radiation Oncology (Maastro), GROW Institute for Oncology and Developmental Biology, Maastricht, Netherlands., Vanneste B; Department of Radiation Oncology (Maastro), GROW Institute for Oncology and Developmental Biology, Maastricht, Netherlands., Van Limbergen E; Maastricht University Medical Center, Maastricht, Netherlands.; Department of Radiation Oncology (Maastro), GROW Institute for Oncology and Developmental Biology, Maastricht, Netherlands., Choudhury A; Translational Radiobiology Group, Division of Cancer Sciences, Manchester Academic Health Science Centre, Christie Hospital, University of Manchester, Manchester, United Kingdom., Elliott RM; Translational Radiobiology Group, Division of Cancer Sciences, Manchester Academic Health Science Centre, Christie Hospital, University of Manchester, Manchester, United Kingdom., Sperk E; Department of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Herskind C; Department of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Veldwijk MR; Department of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Avuzzi B; Department of Radiation Oncology 1, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Giandini T; Department of Medical Physics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Valdagni R; Department of Radiation Oncology 1, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.; Department of Oncology and Haemato-Oncology, University of Milan, Milan, Italy.; Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Cicchetti A; Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Azria D; Department of Radiation Oncology, University Federation of Radiation Oncology, Montpellier Cancer Institute, Univ Montpellier MUSE, Grant INCa_Inserm_DGOS_12553, Inserm U1194, Montpellier, France., Jacquet MF; Department of Radiation Oncology, University Federation of Radiation Oncology, CHU Caremeau, Nîmes, France., Rosenstein BS; Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Stock RG; Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Collado K; Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Vega A; Fundación Pública Galega de Medicina Xenómica, Grupo de Medicina Xenómica (USC), Santiago de Compostela, Spain.; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain.; Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain., Aguado-Barrera ME; Fundación Pública Galega de Medicina Xenómica, Grupo de Medicina Xenómica (USC), Santiago de Compostela, Spain.; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain., Calvo P; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain.; Department of Radiation Oncology, Complexo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain., Dunning AM; Strangeways Research Labs, Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom., Fachal L; Strangeways Research Labs, Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom., Kerns SL; Departments of Radiation Oncology and Surgery, University of Rochester Medical Center, Rochester, New York, NY, United States., Payne D; Centre for Integrated Genomic Medical Research (CIGMR), University of Manchester, Manchester, United Kingdom., Chang-Claude J; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Seibold P; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., West CML; Translational Radiobiology Group, Division of Cancer Sciences, Manchester Academic Health Science Centre, Christie Hospital, University of Manchester, Manchester, United Kingdom., Rancati T; Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Publikováno v: Frontiers in oncology [Front Oncol] 2020 Oct 15; Vol. 10, pp. 541281. Date of Electronic Publication: 2020 Oct 15 (Print Publication: 2020).