Liver cell polyploidization : a pivotal role for binuclear hepatocytes

Autor: Aude Robert, Olivier Brégerie, Chantal Desdouets, Pascale Debey, Christian Bréchot, Jacques-Emanuelle Guidotti

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2003, 278 (21), pp.19095-19101
Journal of Biological Chemistry 21 (278), 19095-19101. (2003)

Polyploidy is a general physiological process indicative of terminal differentiation. During liver growth, this process generates the appearance of tetraploid (4n) and octoploid (8n) hepatocytes with one or two nuclei. The onset of polyploidy in the

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