Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jacques Wepierre"'
Publikováno v:
Skin Pharmacology and Physiology. 7:245-256
Percutaneous absorption occurs after passive diffusion through the different layers of the skin and its appendages. Thereafter, a resorption process into the cutaneous microcirculation brings the compounds into the systemic circulation. The objective
Publikováno v:
Skin Pharmacology and Physiology. 5:99-107
The importance of the transappendageal route on percutaneous absorption was assessed in the hairless rat. Skin permeation of two steroids, hydrocortisone and testosterone, was evaluated in vivo on normal and artificially damaged skin in which follicl
Publikováno v:
Alternatives to Laboratory Animals. 19:324-336
A comparative study of the cytotoxicity of 17 surfactants was performed in vitro on cultured human skin fibroblasts to predict their irritation potential under different experimental conditions: test media, presence of proteins, various times of expo
Publikováno v:
Journal of pharmaceutical sciences. 86(5)
The significance of the sebaceous gland pathway in the cutaneous permeation of an antiandrogen, 4-[3-(4-hydroxybutyl)-4,4-dimethyl -2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile (RU 58841), was studied with normal hairless rat skin and
Publikováno v:
Skin pharmacology : the official journal of the Skin Pharmacology Society. 7(5)
Percutaneous absorption theoretically comprises two components: the transepidermal and the transfollicular routes. The aim of the present work was to confirm this hypothesis in the human skin by comparing the in vitro percutaneous absorption of four
Publikováno v:
Journal of pharmaceutical sciences. 80(5)
The relative importance of stratum corneum and follicles in percutaneous absorption is not fully understood. In order to quantitatively investigate the importance of the transappendageal route, we have previously developed a model of skin without fol
Publikováno v:
International Journal of Cosmetic Science. 1:213-219
Synopsis The unsaponifiable lipidic fractions of avocado and soya bean were administered percutaneously, on the dorsal skin of hairless rats for 15 days, in a 5% sweet almond oil solution. This treatment produced a modification of dermal connective t
Autor:
Monique Prioux-Guyonneau, Christian Jacquot, Henri Sentenac, Elisabeth Cretet, Jacques Wepierre
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 313(2)
The central effects of tabernanthine on noradrenaline and dopamine turnover times were studied in the hypothalamus, the striatum and the remainder of the brain of normal and hypobaric hypoxic rats, the latter state corresponding to 5,200 m (410 mm Hg