Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Jacques U. Baenziger"'
Publikováno v:
Glycobiology. 27:450-456
Expanded access to DNA sequencing now fosters ready detection of site-specific human genome alterations whose actual significance requires in-depth functional study to rule in or out disease-causing mutations. This is a particular concern for genomic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b13b95db14ea09bb74411763c6f93af
https://doi.org/10.1093/glycob/cwx018
https://doi.org/10.1093/glycob/cwx018
Publikováno v:
Journal of Biological Chemistry. 289:12157-12167
The rate at which glycoproteins are cleared from the circulation has a critical impact on their biologic activity in vivo. We have shown that clearance rates for glycoproteins such as luteinizing hormone (LH) that undergo regulated release into the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cbbbfa48accbd0bd957cb09c8d8f90c
https://doi.org/10.1074/jbc.m113.544973
https://doi.org/10.1074/jbc.m113.544973
Autor:
Lindsay Steirer, Gabriela Dveksler, Jacques U. Baenziger, Dorothy Fiete, Yiling Mi, Marcy Coonce, Raymond R. Townsend
The mannose receptor (ManR, Mrc1) and asialoglycoprotein receptor (ASGR, Asgr1 and Asgr2) are highly abundant endocytic receptors expressed by sinusoidal endothelial cells and parenchymal cells in the liver, respectively. We genetically manipulated e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9b9012a582212eb3914a3558221126
https://europepmc.org/articles/PMC5009246/
https://europepmc.org/articles/PMC5009246/
Publikováno v:
Journal of Biological Chemistry. 287:29204-29212
N- and O-linked oligosaccharides on pro-opiomelanocortin both bear the unique terminal sequence SO(4)-4-GalNAcβ1,4GlcNAcβ. We previously demonstrated that protein-specific transfer of GalNAc to N-linked oligosaccharides on glycoprotein substrates i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68aa2ea255b80a174903bcd3b4cbc099
https://doi.org/10.1074/jbc.m112.371880
https://doi.org/10.1074/jbc.m112.371880
Autor:
Andreas R. Janecke, Birgit Krabichler, Robert Gruber, Julia Vodopiutz, Qi Zhang, Munis Dundar, Thomas Müller, Jacques U. Baenziger, Tohru Sonoda, Beat Steinmann, Gerd Utermann, Jing Pan, Lijuan Zhang
Publikováno v:
The American Journal of Human Genetics. 85(6):873-882
Adducted thumb-clubfoot syndrome is an autosomal-recessive disorder characterized by typical facial appearance, wasted build, thin and translucent skin, congenital contractures of thumbs and feet, joint instability, facial clefting, and coagulopathy,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ea89c6ad9145adbc4c5b784d9d266d
Publikováno v:
Journal of Biological Chemistry. 284:3777-3783
The asialoglycoprotein receptor (ASGP-R) is an abundant, carbohydrate-specific, endocytic receptor expressed by parenchymal cells of the liver. We recently demonstrated that the ASGP-R mediates the clearance of glycoproteins bearing Siaalpha2,6GalNAc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef50784b4d26dc41dbb3312f0e3eb777
https://doi.org/10.1074/jbc.m808689200
https://doi.org/10.1074/jbc.m808689200
Publikováno v:
Proceedings of the National Academy of Sciences. 102:17125-17129
Endogenous ligands have not, to date, been identified for the asialoglycoprotein receptor (ASGP-R), which is abundantly expressed by parenchymal cells in the liver of mammals. On the basis of the rapid clearance of BSA bearing multiple chemically cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ced1ed38525b88a8ee32341534bd1da
https://doi.org/10.1073/pnas.0508537102
https://doi.org/10.1073/pnas.0508537102
Publikováno v:
Glycobiology. 15:1349-1358
We have cloned two GalNAc-4-sulfotransferases, GalNAc-4-ST1 and GalNAc-4-ST2, that transfer sulfate to terminal beta1,4-linked GalNAc. In conjunction with the action of protein-specific beta1,4GalNAc-transferases, GalNAc-4-ST1 and GalNAc-4-ST2 accoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1180fb728a1b088623b3d68f4712e456
https://doi.org/10.1093/glycob/cwj024
https://doi.org/10.1093/glycob/cwj024
Autor:
Jacques U. Baenziger
Publikováno v:
Biochemical Society Transactions. 31:326-330
The glycoprotein hormones lutropin (LH) and thyrotropin and a limited number of additional glycoproteins bear carbohydrate structures terminating with the unique sequence SO(4)-4-GalNAcbeta1,4GlcNAcbeta that has been conserved in the glycoprotein hor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a92f4002aa9984754458dcdf86eac241
https://doi.org/10.1042/bst0310326
https://doi.org/10.1042/bst0310326
Publikováno v:
Journal of Biological Chemistry. 278:4597-4602
The asialoglycoprotein-receptor (ASGP-R) located on liver parenchymal cells was originally identified and characterized on the basis of its ability to bind glycoproteins bearing terminal galactose (Gal) or N-acetylgalactosamine (GalNAc); however, end
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34800768fd9de01cc725c4e9bc87f77a
https://doi.org/10.1074/jbc.m210612200
https://doi.org/10.1074/jbc.m210612200