Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jacques Roberge"'
Autor:
Arindam Mondal, Dongxuan Jia, Vrushank Bhatt, Moumen Akel, Jacques Roberge, Jessie Yanxiang Guo, John Langenfeld
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract The imidazolium compound Ym155 was first reported to be a survivin inhibitor. Ym155 potently induces cell death of many types of cancer cells in preclinical studies. However, in phase II clinical trials Ym155 failed to demonstrate a signific
Externí odkaz:
https://doaj.org/article/d110184c34034a6596d3ed5d22a06372
Autor:
Arindam Mondal, Jacques Roberge, John Gilleran, Youyi Peng, Dongxuan Jia, Moumen Akel, Yash Patel, Harrison Zoltowski, Anupama Doraiswamy, John Langenfeld
Publikováno v:
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background Bone morphogenetic proteins (BMP) are evolutionarily conserved morphogens that are reactivated in lung carcinomas. In lung cancer cells, BMP signaling suppresses AMP activated kinase (AMPK) by inhibiting LKB1. AMPK is activated by
Externí odkaz:
https://doaj.org/article/887073c8f6c546c09e3906df94c126cb
Bone morphogenetic protein signaling regulation of AMPK and PI3K in lung cancer cells and C. elegans
Autor:
Mehul Vora, Arindam Mondal, Dongxuan Jia, Pranya Gaddipati, Moumen Akel, John Gilleran, Jacques Roberge, Christopher Rongo, John Langenfeld
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Background Bone morphogenetic protein (BMP) is a phylogenetically conserved signaling pathway required for development that is aberrantly expressed in several age-related diseases including cancer, Alzheimer’s disease, obesity, and cardiov
Externí odkaz:
https://doaj.org/article/b8535fe727a2416da76646ea73630696
Autor:
Arindam Mondal, Rachel NeMoyer, Mehul Vora, Logan Napoli, Zoya Syed, Elaine Langenfeld, Dongxuan Jia, Youyi Peng, John Gilleran, Jacques Roberge, Christopher Rongo, Salma K. Jabbour, John Langenfeld
Publikováno v:
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-15 (2021)
Abstract Background Recent studies have shown that bone morphogenetic protein receptor 2 (BMPR2) regulates cell survival signaling events in cancer cells independent of the BMP type 1 receptor (BMPR1) or the Smad-1/5 transcription factor. Mutations i
Externí odkaz:
https://doaj.org/article/69e13be64bb24a12811f30521a80e6ca
Autor:
Eileen Carry, Dushyant Kshatriya, Joshua Silva, Daryl L. Davies, Bo Yuan, Qingli Wu, Harna Patel, Elizabeth R. Park, John Gilleran, Lihong Hao, Jacques Roberge, Nicholas T. Bello, James E. Simon
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7460 (2021)
Dihydromyricetin is a natural bioactive flavonoid with unique GABAA receptor activity with a putative mechanism of action to reduce the intoxication effects of ethanol. Although dihydromyricetin’s poor oral bioavailability limits clinical utility,
Externí odkaz:
https://doaj.org/article/771df6ab519c4603bd4bf0d3e4101b85
Autor:
John A. Gilleran, S. David Kimball, Jacques Roberge, Alan J. Blayney, Stewart N. Loh, Adam R. Blanden, David Augeri, Darren R. Carpizo, Anthony F. Bencivenga, Xin Yu, Bing Na
Publikováno v:
J Med Chem
We identified a set of thiosemicarbazone (TSC) metal ion chelators that reactivate specific zinc-deficient p53 mutants using a mechanism called zinc metallochaperones (ZMCs) that restore zinc binding by shuttling zinc into cells. We defined biophysic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37960bf2b8c996bc4b1a6bffd407a5ac
https://doi.org/10.1021/acs.jmedchem.0c01360
https://doi.org/10.1021/acs.jmedchem.0c01360
Autor:
Xiao-Ping Li, Bin Cao, Jacques Roberge, Nilgun E. Tumer, David Augeri, Anastasiia M Tsymbal, Michael Pierce, Jennifer Nielsen Kahn, Rajesh K. Harijan
Publikováno v:
Journal of medicinal chemistry. 64(20)
Ricin toxin A subunit (RTA) is the catalytic subunit of ricin, which depurinates an adenine from the sarcin/ricin loop in eukaryotic ribosomes. There are no approved inhibitors against ricin. We used a new strategy to disrupt RTA-ribosome interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98582b494a2052d8b5837c327e69e18
https://pubmed.ncbi.nlm.nih.gov/34648707
https://pubmed.ncbi.nlm.nih.gov/34648707
Autor:
Qingli Wu, John A. Gilleran, Harna Patel, Nicholas T. Bello, Lihong Hao, Eileen Carry, James E. Simon, Bo Yuan, Jacques Roberge, Daryl L. Davies, Dushyant Kshatriya, Elizabeth R. Park, Joshua Silva
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 7460, p 7460 (2021)
Volume 22
Issue 14
International Journal of Molecular Sciences, Vol 22, Iss 7460, p 7460 (2021)
Volume 22
Issue 14
Dihydromyricetin is a natural bioactive flavonoid with unique GABAA receptor activity with a putative mechanism of action to reduce the intoxication effects of ethanol. Although dihydromyricetin’s poor oral bioavailability limits clinical utility,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae38dac29769dc357e7a43417b363d5f
http://europepmc.org/articles/PMC8307506
http://europepmc.org/articles/PMC8307506
Autor:
Jing Liang, Jacques Roberge, Daryl L. Davies, Eileen Carry, Chen Xue, Joshua Silva, Jifeng Zhang
Publikováno v:
Molecules
Volume 26
Issue 6
Molecules, Vol 26, Iss 1791, p 1791 (2021)
Volume 26
Issue 6
Molecules, Vol 26, Iss 1791, p 1791 (2021)
Alcohol use disorder (AUD) affects over 18 million people in the US. Unfortunately, pharmacotherapies available for AUD have limited clinical success and are under prescribed. Previously, we established that avermectin compounds (ivermectin [IVM] and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d4f668d2e64b25f5a269badb6c955f2
Autor:
Salma K. Jabbour, John Langenfeld, Elaine Langenfeld, Logan Napoli, Jacques Roberge, Arindam Mondal, Youyi Peng, Dongxuan Jia, John A. Gilleran, Christopher Rongo, Zoya Syed, Rachel NeMoyer, Mehul Vora
Publikováno v:
Cell Communication and Signaling : CCS
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-15 (2021)
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-15 (2021)
BackgroundRecent studies have shown that bone morphogenetic protein receptor 2 (BMPR2) regulates cell survival signaling events in cancer cells independent of the BMP type 1 receptor (BMPR1) or the Smad-1/5 transcription factor. Mutations in BMPR2 tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aeb4478bc0be2fd7b129abd3e46cfdc
https://pubmed.ncbi.nlm.nih.gov/34563224
https://pubmed.ncbi.nlm.nih.gov/34563224