Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Jacques Prudhomme"'
Autor:
Thomas Hollin, Steven Abel, Charles Banks, Borislav Hristov, Jacques Prudhomme, Kianna Hales, Laurence Florens, William Stafford Noble, Karine G. Le Roch
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Ribonucleoprotein complexes are composed of RNA, RNA-dependent proteins (RDPs) and RNA-binding proteins (RBPs), and play fundamental roles in RNA regulation. However, in the human malaria parasite, Plasmodium falciparum, identification and c
Externí odkaz:
https://doaj.org/article/4573a320ff5f4aa8bbb69c437e80ca21
Autor:
Gayani Batugedara, Xueqing M. Lu, Borislav Hristov, Steven Abel, Zeinab Chahine, Thomas Hollin, Desiree Williams, Tina Wang, Anthony Cort, Todd Lenz, Trevor A. Thompson, Jacques Prudhomme, Abhai K. Tripathi, Guoyue Xu, Juliana Cudini, Sunil Dogga, Mara Lawniczak, William Stafford Noble, Photini Sinnis, Karine G. Le Roch
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The complex life cycle of Plasmodium falciparum requires coordinated gene expression regulation to allow host cell invasion, transmission, and immune evasion. Increasing evidence now suggests a major role for epigenetic mechanisms in gene ex
Externí odkaz:
https://doaj.org/article/f2a81b4d714045ac8d01aa238cd881cc
Autor:
Thomas Hollin, Steven Abel, Alejandra Falla, Charisse Flerida A. Pasaje, Anil Bhatia, Manhoi Hur, Jay S. Kirkwood, Anita Saraf, Jacques Prudhomme, Amancio De Souza, Laurence Florens, Jacquin C. Niles, Karine G. Le Roch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The function of RNA-binding domain abundant in Apicomplexans (RAP) protein family members is largely unknown. Here, using high-throughput functional genomics, including metabolomics, Hollin et al. characterize two RAP proteins that are essential for
Externí odkaz:
https://doaj.org/article/094d1d1baf8f47fca002306e194e4932
Autor:
Evelien M. Bunnik, Kate B. Cook, Nelle Varoquaux, Gayani Batugedara, Jacques Prudhomme, Anthony Cort, Lirong Shi, Chiara Andolina, Leila S. Ross, Declan Brady, David A. Fidock, Francois Nosten, Rita Tewari, Photini Sinnis, Ferhat Ay, Jean-Philippe Vert, William Stafford Noble, Karine G. Le Roch
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The development of malaria parasites is controlled by coordinated changes in gene expression. Here, the authors show that the three-dimensional genome structure of human malaria parasites is strongly connected with transcriptional activity of specifi
Externí odkaz:
https://doaj.org/article/4a6a36d14fb4490e84769dc9194c6458
Autor:
Swati Agrawal, Duk-Won D Chung, Nadia Ponts, Giel G van Dooren, Jacques Prudhomme, Carrie F Brooks, Elisadra M Rodrigues, John C Tan, Michael T Ferdig, Boris Striepen, Karine G Le Roch
Publikováno v:
PLoS Pathogens, Vol 9, Iss 6, p e1003426 (2013)
Apicomplexan parasites are responsible for numerous important human diseases including toxoplasmosis, cryptosporidiosis, and most importantly malaria. There is a constant need for new antimalarials, and one of most keenly pursued drug targets is an a
Externí odkaz:
https://doaj.org/article/25749d8909aa40a584833210ddcf13ac
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43477 (2012)
Ubiquitin-dependent protein degradation within malarial parasites is a burgeoning field of interest due to several encouraging reports of proteasome inhibitors that were able to confer antimalarial activity. Despite the growing interest in the Plasmo
Externí odkaz:
https://doaj.org/article/923a24d2e1974f0e804762c8ad02b6cd
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 87, Pp 303-312 (1992)
The vast majority of the 1-2 million malaria associated deaths that occur each year are due to anemia and cerebral malaria (the attachment of erythrocytes containing mature forms of Plasmodium falciparum to the endothelial cells that line the vascula
Externí odkaz:
https://doaj.org/article/dca1b58284ad4fc2874d09593c32839d
Autor:
Jacques Prudhomme, Eric McDaniel, Nadia Ponts, Stéphane Bertani, William Fenical, Paul Jensen, Karine Le Roch
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2335 (2008)
Malaria continues to be a devastating parasitic disease that causes the death of 2 million individuals annually. The increase in multi-drug resistance together with the absence of an efficient vaccine hastens the need for speedy and comprehensive ant
Externí odkaz:
https://doaj.org/article/936a1588b42d416b8720feb85e6d451b
Autor:
Nadia Ponts, Jianfeng Yang, Duk-Won Doug Chung, Jacques Prudhomme, Thomas Girke, Paul Horrocks, Karine G Le Roch
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2386 (2008)
BACKGROUND: Reversible modification of proteins through the attachment of ubiquitin or ubiquitin-like modifiers is an essential post-translational regulatory mechanism in eukaryotes. The conjugation of ubiquitin or ubiquitin-like proteins has been de
Externí odkaz:
https://doaj.org/article/db5b08f8686d46df860e688a6fc7c66d
Autor:
Gayani Batugedara, Xueqing M. Lu, Steven Abel, Zeinab Chahine, Borislav Hristov, Desiree Williams, Thomas Hollin, Tina Wang, Anthony Cort, Todd Lenz, Trevor Thompson, Jacques Prudhomme, Abhai K. Tripathi, Guoyue Xu, Juliana Cudini, Sunil Dogga, Mara Lawniczak, William Stafford Noble, Photini Sinnis, Karine G. Le Roch
The complex life cycle ofPlasmodium falciparumrequires coordinated gene expression regulation to allow host cell invasion, transmission, and immune evasion. However, this cascade of transcripts is unlikely to be regulated by the limited number of ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d8c3bc30a808b2ec700d46893d9df02
https://doi.org/10.1101/2022.10.12.511630
https://doi.org/10.1101/2022.10.12.511630
