Výsledky vyhledávání - "Jacques Plummer"

Abstract 1791: Next generation UltraCAR-T® cells with intrinsic checkpoint inhibition and overnight manufacturing overcome suppressive tumor microenvironment leading to sustained antitumor activity

Autor: Giorgio Zenere, Carol Poortman, Afreen Sayed, Devi Gunasekera, Cheryl Bolinger, Pooja Chauhan, Jacques Plummer, Shamim Ahmad, Rutul R. Shah, Helen Sabzevari, Douglas E. Brough, Tim Chan

Publikováno v: Cancer Research. 83:1791-1791

The UltraCAR-T® platform, with decentralized overnight manufacturing, has shifted the autologous CAR-T manufacturing paradigm. This disruptive approach has been validated in clinical and pre-clinical studies for both hematologic and solid tumors. Ul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4b1e4bcdf7c1f32b8864a9bbc73653a
https://doi.org/10.1158/1538-7445.am2023-1791

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Abstract 2821: Incorporation of intrinsic checkpoint blockade enhances functionality of multigenic autologous UltraCAR-T® cells manufactured using non-viral gene delivery and rapid manufacturing process

Publikováno v: Cancer Research. 82:2821-2821

Current chimeric antigen receptor (CAR)-T manufacturing utilizes viral vectors and extensive ex vivo expansion at large central facilities leading to an exhausted CAR-T phenotype, high costs and long vein-to-vein times. While allogeneic CAR-T can red

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63133a1ac856a76bf48a2068e0fb3c51
https://doi.org/10.1158/1538-7445.am2022-2821

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Preclinical Evaluation of Prgn-3007, a Non-Viral, Multigenic, Autologous ROR1 Ultracar-T ® Therapy with Novel Mechanism of Intrinsic PD-1 Blockade for Treatment of Hematological and Solid Cancers

Publikováno v: Blood. 138:1694-1694

Traditional methods for chimeric antigen receptor (CAR) T manufacturing utilize viral vectors, ex vivo activation and expansion of T cells to achieve clinically relevant cell numbers, which leads to an exhausted T cell phenotype, high manufacturing c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a15f4b9864fcf5fa4c9f1ebfad13ef0
https://doi.org/10.1182/blood-2021-149203

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Abstract 6593: PRGN-3005 UltraCAR-T™: multigenic CAR-T cells generated using non-viral gene delivery and rapid manufacturing process for the treatment of ovarian cancer

Autor: Padma Kamineny, Simon Metenou, Adeline Govekung, Marion Chakiath, Jose Velez, Shah Rutul R, Tim Chan, Jacques Plummer, Fernando Carvajal-Borda, Helen Sabzevari, Carol Poortman, Xiaohong Ma, Mary L. Disis, Lindsey Shepard

Publikováno v: Cancer Research. 80:6593-6593

Ovarian cancer is the most lethal of gynecologic cancers. Chimeric antigen receptor (CAR)-T cells have improved clinical outcomes in hematological malignancies; however similar responses have not yet been achieved for solid tumors. Furthermore, tradi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c198ed4e1656db78e606d35925e469d
https://doi.org/10.1158/1538-7445.am2020-6593

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Preclinical Characterization of Prgn-3006 Ultracar-T™ for the Treatment of AML and MDS: Non-Viral, Multigenic Autologous CAR-T Cells Administered One Day after Gene Transfer

Autor: Jose Velez, Fernando Carvajal-Borda, Shah Rutul R, Helen Sabzevari, Xiaohong Ma, Lindsey Shepard, David A. Sallman, Tim Chan, Jacques Plummer

Publikováno v: Blood. 134:2660-2660

Relapsed/refractory (r/r) acute myeloid leukemia (AML) is an aggressive malignancy with poor prognosis and limited treatment options underscoring the need for new therapies. Traditional methods for generating CAR-T cells require extensive ex vivo exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dcf2eb37f30ff3bd97c3377ac0c88090
https://doi.org/10.1182/blood-2019-130617

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Abstract B127: Pharmacodynamics and functionality of RheoSwitch® regulated immunomodulatory proteins, expressed from a multigenic embedded cellular bioreactor following intramuscular electroporation in mice

Autor: Tim Chan, Michele Kaloss, Lindsay Williams, John A. Barrett, Richard Einstein, Thomas Reed, Laurent M. Humeau, Stephen Schauer, Jacques Plummer, Xiaohong Ma, Pooja Agarwal

Publikováno v: Molecular Cancer Therapeutics. 12:B127-B127

Over the past decade, immunotherapies have emerged as prominent means to fight cancer. It is currently well accepted that combining multiple immunomodulatory therapeutic modalities will likely have a deeper impact in promoting cancer remission than m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::630406d4f81539b51b2989ee3c91a17c
https://doi.org/10.1158/1535-7163.targ-13-b127

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