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pro vyhledávání: '"Jacques Nunez"'
Thyroid hormone (TH) is important in both the development and adult function of the central nervous system (CNS). In human development, lack of iodine or congenital abnormalities in TH production or action are known causes of mental retardation. TH a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b87a880db147eb3e61a79c49c868c88
https://doi.org/10.1016/b978-0-12-809324-5.02258-6
https://doi.org/10.1016/b978-0-12-809324-5.02258-6
Publikováno v:
Molecular and Cellular Endocrinology. 287:1-12
Thyroid hormone (TH) has a remarkable range of actions in the development and function of the nervous system. A multigenic picture is emerging of the mechanisms that specify these diverse functions in target tissues. Distinct responses are mediated b
Autor:
Dominique Couchie, Jack Puymirat, Jacques Nunez, J. Guilleminot, Andrée Tixier-Vidal, A. Faivre-Bauman
Publikováno v:
Journal of Neurochemistry. 47:1255-1261
Immunoblotting analysis was used to identify the microtubule-associated proteins (MAPs) present in cultures of mouse brain neurons. Polyclonal antibodies were raised against the two main adult brain MAPs, i.e., MAP2 (300 kDa) and tau (60-70 kDa). Wha
Publikováno v:
European Journal of Biochemistry. 118:239-245
The respective role of iodide and of free diiodotyrosine on thyroid hormone synthesis (coupling reaction) has been analyzed under a variety of enzymatic and non-enzymatic conditions. The coupling reaction was studied either during the course of the i
Publikováno v:
European Journal of Biochemistry. 117:103-109
1 When thyroglobulin iodination by thyroid peroxidase or lactoperoxidase is studied with optimal concentrations of H2O2-generating system, thyroid hormone synthesis (coupling reaction) begins after a constant lag period which is independent of the co
Autor:
Jacques Nunez, Kazuaki Shimoji, Hideyo Suzuki, Michelle Cook, Takanori Esaki, Sheue-yann Cheng, Louis Sokoloff
Publikováno v:
Endocrinology. 144:4117-4122
Neonatal hypothyroidism impairs structural maturation in the brain and results in diminished electrical activities and energy metabolism. We recently found that glucose utilization (CMR(glc)) is markedly depressed throughout the brain in mice with ta
Publikováno v:
Journal of Neurochemistry. 63:2300-2306
We show in this work that high-molecular-weight (HMW) tau transcripts are present in all the regions of the CNS and PNS studied, i.e., the dorsal root ganglia (DRG), spinal cord, cerebellum, and forebrain. However, the relative amount of HMW and low-
Publikováno v:
Journal of Molecular Neuroscience. 7:193-201
The high-mol-wt forms of brain microtubule-associated protein 2 (MAP2a/b) segregate within the dendrites during neuronal differentiation, whereas a low-mol-wt variant, MAP2c, is distributed within all the neuronal domains. Both MAP2b and MAP2c contai
Autor:
Jacques Nunez, Juan Bernal
Publikováno v:
European Journal of Endocrinology. 133:390-398
Bernal J, Nunez J. Thyroid hormones and brain development. Eur J Endocrinol 1995;133:390–8. ISSN 0804–4643 Thyroid hormone is a major physiological regulator of mammalian brain development. Cell differentiation, migration and gene expression are
Publikováno v:
Neurobiology of Aging. 16:243-246