Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Jacques Jami"'
Autor:
Jacques Jami, P Schaerly, Andras Paldi, Bertrand Duvillié, Louise Deltour, K Kelemen, Y Jouvenot, Julien Vandamme
Publikováno v:
Gene Expression Patterns. 5:297-300
There are two functional insulin genes in the mouse genome. The Ins2 gene is imprinted and expressed monoallelically from the paternal allele in the yolk sac. In the present study we have re-examined the imprinting status of Ins1. We found that Ins1
Autor:
Joëlle Morin, Véronique Laloux, D. Dubois-Laforgue, Jean-Claude Carel, Patricia Krief, Philippe Halbout, Christian Boitard, Agnès Lehuen, Sylviane Muller, Jacques Jami, Karine Vallon-Geoffroy, Jean-Paul Briand, Karine Thébault-Baumont
Publikováno v:
Journal of Clinical Investigation. 111:851-857
Accumulating evidence favors a role for proinsulin as a key autoantigen in diabetes. In the mouse, two proinsulin isoforms coexist. Most studies point to proinsulin 2 as the major isoform recognized by T cells in the NOD mouse. We studied mice in whi
Autor:
Danièle Dubois-Lafforgue, Jacques Jami, Laurent Mogenet, Christian Boitard, Patricia Krief, Karine Thébault
Publikováno v:
Diabetes. 51:S489-S493
Insulin is a major disease determinant in type 1 diabetes, type 2 diabetes, and related disorders. The role of variations in the expression of the insulin gene has been proposed in genetic susceptibility to the three pathological conditions in humans
Publikováno v:
Diabetologia
Diabetologia, Springer Verlag, 2002, 45 (9), pp.1292-1297. ⟨10.1007/s00125-002-0881-y⟩
Diabetologia, Springer Verlag, 2002, 45 (9), pp.1292-1297. ⟨10.1007/s00125-002-0881-y⟩
Insulin receptor null mutant mice develop severe diabetes, ketoacidosis and liver steatosis and die within 1 week after birth. Since the liver plays an essential role in the control of glucose homeostasis, we examined in this work whether the metabol
Publikováno v:
Current Biology. 9:1199-1202
The H19 and insulin-like growth factor 2 ( Igf2 ) genes in the mouse are models for genomic imprinting during development. The genes are located only 90 kb apart in the same transcriptional orientation [1], but are reciprocally imprinted: Igf2 is pat
Publikováno v:
Genomics. 47:52-57
The mouse gene encoding preproinsulin 2 ( Ins2 ) is located on the distal end of chromosome 7 in a region of several hundred kilobases that contains several imprinted genes. The exclusive expression of the Ins2 paternal allele in the visceral yolk sa
Autor:
Jacques Jami, Danielle Bucchini, Bertrand Duvillié, Susan Saint-Just, Betty Lamothe, Nathalie Cordonnier, Rajiv L. Joshi, Anne Baudry
Publikováno v:
Molecular and Cellular Biochemistry. 182:161-168
Transgenic and gene targeting approaches have now been applied to a number of genes in order to investigate the metabolic disorders that would result by manipulating insulin action or pancreatic β-cell function in the mouse. The availability of such
Autor:
Pierrette Desbois, Jean-Michel Itier, Philippe Douhet, Jacques Jami, Rajiv L. Joshi, Françoise Dandoy-Dron, Danielle Bucchini
Publikováno v:
Differentiation
Differentiation, Elsevier, 1996, 60 (5), pp.309-316. ⟨10.1046/j.1432-0436.1996.6050309.x⟩
Differentiation, Elsevier, 1996, 60 (5), pp.309-316. ⟨10.1046/j.1432-0436.1996.6050309.x⟩
A mini-human insulin gene and four derivatives mutated at several regions potentially involved in the regulation of gene expression were used to generate transgenic mouse lines. The effect of these mutations on the efficiency of gene expression and c
Autor:
Niels Blume, Patrick Leduque, Danielle Bucchini, Jacques Jami, Ole D. Madsen, Paul Dubois, Louise Deltour
Publikováno v:
Proceedings of the National Academy of Sciences. 90:527-531
In the mouse, insulin is produced from two similar but nonallelic genes that encode proinsulins I and II. We have investigated expression of these two genes during mouse embryonic development, using a PCR to detect the two gene transcripts and immuno
Publikováno v:
Journal of Cellular Physiology. 146:349-355
Insulin gene expression in rat insulinoma (RIN) cells is extinct in RIN × fibroblast hybrids and can reappear upon loss of DNA contributed by the fibroblast parent. (Besnard et al., Exp. Cell Res. 185:101–108, 1989). In the present study, we looke