Extracellular Vesicles Are Conveyors of the NS1 Toxin during Dengue Virus and Zika Virus Infection

Autor: Daed El Safadi, Grégorie Lebeau, Alisé Lagrave, Julien Mélade, Lauriane Grondin, Sarah Rosanaly, Floran Begue, Mathilde Hoareau, Bryan Veeren, Marjolaine Roche, Jean-Jacques Hoarau, Olivier Meilhac, Patrick Mavingui, Philippe Desprès, Wildriss Viranaïcken, Pascale Krejbich-Trotot

Publikováno v: Viruses, Vol 15, Iss 2, p 364 (2023)

Extracellular vesicles (EVs), produced during viral infections, are of emerging interest in understanding infectious processes and host–pathogen interactions. EVs and exosomes in particular have the natural ability to transport nucleic acids, prote

Externí odkaz: https://doaj.org/article/a4b7b9bc32bf445e9f4b98f8433bba75

Zika E Glycan Loop Region and Guillain–Barré Syndrome-Related Proteins: A Possible Molecular Mimicry to Be Taken in Account for Vaccine Development

Autor: Grégorie Lebeau, Etienne Frumence, Jonathan Turpin, Floran Begue, Jean-Jacques Hoarau, Gilles Gadea, Pascale Krejbich-Trotot, Philippe Desprès, Wildriss Viranaicken

Publikováno v: Vaccines, Vol 9, Iss 3, p 283 (2021)

The neurological complications of infection by the mosquito-borne Zika virus (ZIKV) include Guillain–Barré syndrome (GBS), an acute inflammatory demyelinating polyneuritis. GBS was first associated with recent ZIKV epidemics caused by the emergenc

Externí odkaz: https://doaj.org/article/6cc82d5b5f5f4b2982307ed05fc93164

Viral Toxin NS1 Implication in Dengue Pathogenesis Making It a Pivotal Target in Development of Efficient Vaccine

Autor: Pascale Krejbich-Trotot, Grégorie Lebeau, Alisé Lagrave, Marjolaine Roche, Wildriss Viranaicken, Philippe Desprès, Soundary Seriacaroupin, Cédric Moutoussamy, Jean-Jacques Hoarau, Lauriane Grondin, Patrick Mavingui, Eva Ogire

Publikováno v: Vaccines
Vaccines, 2021, 9 (9), ⟨10.3390/vaccines9090946⟩
Vaccines, Vol 9, Iss 946, p 946 (2021)

International audience; The mosquito-borne viral disease dengue is a global public health problem causing a wide spectrum of clinical manifestations ranging from mild dengue fever to severe dengue with plasma leakage and bleeding which are often fata

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fdd44592d00fedfc5a88ac3c247cf32
https://hal.univ-reunion.fr/hal-03703022

Identical strength of the T cell responses against E2, nsP1 and capsid CHIKV proteins in recovered and chronic patients after the epidemics of 2005-2006 in La Reunion Island.

Autor: Jean-Jacques Hoarau, Frederick Gay, Olivier Pellé, Assia Samri, Marie-Christine Jaffar-Bandjee, Philippe Gasque, Brigitte Autran

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e84695 (2013)

To characterize the immunity developed by patients infected by chikungunya virus (CHIKV), we studied the intensity and specificity of CHIKV-specific T cells mediated responses in chronic and recovered patients at 12 to 24 months post-infection. T cel

Externí odkaz: https://doaj.org/article/ee8e2f3ae08c4dbdbd5bb1790b9521f6

Emergence and clinical insights into the pathology of Chikungunya virus infection

Autor: Jean Jacques Hoarau, Stéphanie Robin, Anne Ribera, Duksha Ramful, Marie Christine Jaffar-Bandjee, Bernard Alex Gaüzère, Philippe Gasque, Jimmy Selambarom, Pascale Krejbich-Trotot

Publikováno v: Expert Review of Anti-infective Therapy
Expert Review of Anti-infective Therapy, Expert Reviews, 2010, 8 (9), pp.987--996. ⟨10.1586/eri.10.92⟩

International audience; Major epidemics of Chikungunya have re-emerged with millions of cases worldwide. What was once largely a tropical disease in poorer countries is now recognized as a major global health issue. The disease is perpetuated by the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6567e81f7d8e35cea2d739ba4729a5
https://doi.org/10.1586/eri.10.92