Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Jacques Ghysdael"'
Autor:
Marie-Emilie Dourthe, Etienne Lengline, Guillaume Charbonnier, Mehdi Latiri, Chaimae Saji, Agata Cieslak, Mathieu Simonin, Norbert Ifrah, Hervé Dombret, Olivier Hermine, Nicolas Boissel, André Baruchel, Jacques Ghysdael, Elizabeth Macintyre, Christine Tran-Quang, Guillaume Andrieu, Vahid Asnafi
Publikováno v:
HemaSphere, Vol 7, p e97465b3 (2023)
Externí odkaz:
https://doaj.org/article/040ecc6c2e754a43b742a30c232139f8
Autor:
Charlotte Smith, Aurore Touzart, Mathieu Simonin, Christine Tran-Quang, Guillaume Hypolite, Mehdi Latiri, Guillaume P. Andrieu, Estelle Balducci, Marie-Émilie Dourthe, Ashish Goyal, Françoise Huguet, Arnaud Petit, Norbert Ifrah, André Baruchel, Hervé Dombret, Elizabeth Macintyre, Christoph Plass, Jacques Ghysdael, Nicolas Boissel, Vahid Asnafi
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-7 (2023)
Abstract The acquisition of genetic abnormalities engendering oncogene dysregulation underpins cancer development. Certain proto-oncogenes possess several dysregulation mechanisms, yet how each mechanism impacts clinical outcome is unclear. Using T-c
Externí odkaz:
https://doaj.org/article/4734bedc577342f6ab4cb273d503e554
Autor:
Jeannig Berrou, Mélanie Dupont, Hanane Djamai, Emilie Adicéam, Véronique Parietti, Anna Kaci, Emmanuelle Clappier, Jean-Michel Cayuela, André Baruchel, Fabrice Paublant, Renaud Prudent, Jacques Ghysdael, Claude Gardin, Hervé Dombret, Thorsten Braun
Publikováno v:
Journal of Clinical Medicine, Vol 11, Iss 22, p 6761 (2022)
Ph+ (BCR::ABL+) B-ALL was considered to be high risk, but recent advances in BCR::ABL-targeting TKIs has shown improved outcomes in combination with backbone chemotherapy. Nevertheless, new treatment strategies are needed, including approaches withou
Externí odkaz:
https://doaj.org/article/b8ef5dd2b6894ca7b53f74bb99898a4a
Autor:
Claire Catherinet, Diana Passaro, Stéphanie Gachet, Hind Medyouf, Anne Reynaud, Charlène Lasgi, Jacques Ghysdael, Christine Tran Quang
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0254184 (2021)
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy with few available targeted therapies. We previously reported that the phosphatase calcineurin (Cn) is required for LIC (leukemia Initiating Capacity) potential of T-ALL pointing
Externí odkaz:
https://doaj.org/article/2035fe1092774cfca12dbb1b405d0995
Autor:
Benjamin Uzan, Sandrine Poglio, Bastien Gerby, Ching‐Lien Wu, Julia Gross, Florence Armstrong, Julien Calvo, Xavier Cahu, Caroline Deswarte, Florent Dumont, Diana Passaro, Corinne Besnard‐Guérin, Thierry Leblanc, André Baruchel, Judith Landman‐Parker, Paola Ballerini, Véronique Baud, Jacques Ghysdael, Frédéric Baleydier, Francoise Porteu, Francoise Pflumio
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 6, Pp 821-834 (2014)
Abstract Development of novel therapies is critical for T‐cell acute leukaemia (T‐ALL). Here, we investigated the effect of inhibiting the MAPK/MEK/ERK pathway on T‐ALL cell growth. Unexpectedly, MEK inhibitors (MEKi) enhanced growth of 70% of
Externí odkaz:
https://doaj.org/article/7da05d3e2efb44aeb069f4d5b6f9f963
Autor:
Michaela Waibel, Vanessa S. Solomon, Deborah A. Knight, Rachael A. Ralli, Sang-Kyu Kim, Kellie-Marie Banks, Eva Vidacs, Clemence Virely, Keith C.S. Sia, Lauryn S. Bracken, Racquel Collins-Underwood, Christina Drenberg, Laura B. Ramsey, Sara C. Meyer, Megumi Takiguchi, Ross A. Dickins, Ross Levine, Jacques Ghysdael, Mark A. Dawson, Richard B. Lock, Charles G. Mullighan, Ricky W. Johnstone
Publikováno v:
Cell Reports, Vol 5, Iss 4, Pp 1047-1059 (2013)
To design rational therapies for JAK2-driven hematological malignancies, we functionally dissected the key survival pathways downstream of hyperactive JAK2. In tumors driven by mutant JAK2, Stat1, Stat3, Stat5, and the Pi3k and Mek/Erk pathways were
Externí odkaz:
https://doaj.org/article/038b13b134c84948ae45ebf210800b23
Autor:
Edwin D Hawkins, Jane Oliaro, Kelly M Ramsbottom, Stephen B Ting, Faruk Sacirbegovic, Michael Harvey, Tanja Kinwell, Jacques Ghysdael, Ricky W Johnstone, Patrick O Humbert, Sarah M Russell
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87376 (2014)
In epithelial and stem cells, lethal giant larvae (Lgl) is a potent tumour suppressor, a regulator of Notch signalling, and a mediator of cell fate via asymmetric cell division. Recent evidence suggests that the function of Lgl is conserved in mammal
Externí odkaz:
https://doaj.org/article/21030384c0c046c3b08fa7383b62b3dc
Autor:
Ana Leticia Maragno, Martine Pironin, Hélène Alcalde, Xiuli Cong, Klaus-Peter Knobeloch, Frederic Tangy, Dong-Er Zhang, Jacques Ghysdael, Christine Tran Quang
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26068 (2011)
Activation of erythropoietin receptor allows erythroblasts to generate erythrocytes. In a search for genes that are up-regulated during this differentiation process, we have identified ISG15 as being induced during late erythroid differentiation. ISG
Externí odkaz:
https://doaj.org/article/9c01e5d590c24c1d92496e5dc622cded
Autor:
Nuno R dos Santos, Maryvonne Williame, Stéphanie Gachet, Françoise Cormier, Anne Janin, Debra Weih, Falk Weih, Jacques Ghysdael
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2555 (2008)
BACKGROUND: The Rel/NF-kappaB transcription factors are often activated in solid or hematological malignancies. In most cases, NF-kappaB activation is found in malignant cells and results from activation of the canonical NF-kappaB pathway, leading to
Externí odkaz:
https://doaj.org/article/93370d6cf1e54611a04af7bff76c713b
Autor:
Vahid Asnafi, Jacques Ghysdael, Elizabeth Macintyre, Olivier Hermine, David-Alexandre Gross, Lucienne Chatenoud, Salvatore Spicuglia, Hervé Dombret, Norbert Ifrah, Françoise Pflumio, Els Verhoeyen, François-Loïc Cosset, Michael Dussiot, Melania Tesio, Ludovic Lhermitte, Cindy Da Costa de Jesus, Mohamed Belhocine, Benedetta Zaniboni, Francesca Rocchetti, Christine Tran Quang, Nuno R. dos Santos, Amélie Trinquand
Supplementary Methods, Figure Legends, Table Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d1117aba1e2c5684481469fa8f41cb6
https://doi.org/10.1158/2159-8290.22531314
https://doi.org/10.1158/2159-8290.22531314