Výsledky vyhledávání - "Jacques Delaye"

THIOPURINE S-METHYLTRANSFERASE GENE POLYMORPHISM IS PREDICTIVE OF AZATHIOPRINE-INDUCED MYELOSUPPRESSION IN HEART TRANSPLANT RECIPIENTS

Autor: Philippe Boucher, Jean-Jacques Vallon, Paul Davelu, Jean Ninet, Jean-François Obadia, Pascale Boissonnat, Jacques Delaye, G. Champsaur, Georges Dureau, Laurent Sebbag

Publikováno v: Scopus-Elsevier

Azathioprine (AZA) is metabolized via the cytosolic enzyme thiopurine S-methyltransferase (TPMT). TPMT activity exhibits genetic polymorphism with four prevalent (75%) mutant alleles TPMT * 2 (G238C) and TPMT * 3 (A719G and/or G460A) and a wild-type

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a81e0b662b63116834f8626b6440f9c
https://doi.org/10.1097/00007890-200004150-00057

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Liver transplantation resolves the hyperdynamic circulation in hereditary hemorrhagic telangiectasia with hepatic involvement

Autor: Jacques Delaye, Isabelle Mechet, François Mion, Pierre Paliard, Francesco Bianco, Danielle Gille, Henri Plauchu, Olivier Boillot, Jean-Paul Viale

Publikováno v: Gastroenterology. 116(1)

Background & Aims: Hepatic involvement in hereditary hemorrhagic telangiectasia is common but often asymptomatic. However, in some cases, the vascular lesions that involve the liver may lead to high-output cardiac failure and pulmonary hypertension t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d99a96cf58de8ec57187b8698d603af
https://pubmed.ncbi.nlm.nih.gov/9869617

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