Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jacques Deguine"'
Autor:
Jiarui Ding, John J. Garber, Amiko Uchida, Ariel Lefkovith, Grace T. Carter, Praveen Vimalathas, Lauren Canha, Michael Dougan, Kyle Staller, Joseph Yarze, Toni M. Delorey, Orit Rozenblatt-Rosen, Orr Ashenberg, Daniel B. Graham, Jacques Deguine, Aviv Regev, Ramnik J. Xavier
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Coordinated cell interactions within the esophagus maintain homeostasis, and disruption can lead to eosinophilic esophagitis (EoE), a chronic inflammatory disease with poorly understood pathogenesis. We profile 421,312 individual cells from
Externí odkaz:
https://doaj.org/article/0442cca45bfc4b01b6f06f0a4b36b4f3
Autor:
Jinjin Xu, Lingjia Kong, Blayne A. Oliver, Bihua Li, Elizabeth A. Creasey, Gaelen Guzman, Monica Schenone, Kimberly L. Carey, Steven A. Carr, Daniel B. Graham, Jacques Deguine, Ramnik J. Xavier
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112708- (2023)
Summary: Autophagy is an essential cellular process that is deeply integrated with innate immune signaling; however, studies that examine the impact of autophagic modulation in the context of inflammatory conditions are lacking. Here, using mice with
Externí odkaz:
https://doaj.org/article/f9611e7977944a31a27cb9364c77c01a
Autor:
Carolyn M Walsh, Rose Z Hill, Jamie Schwendinger-Schreck, Jacques Deguine, Emily C Brock, Natalie Kucirek, Ziad Rifi, Jessica Wei, Karsten Gronert, Rachel B Brem, Gregory M Barton, Diana M Bautista
Publikováno v:
eLife, Vol 8 (2019)
Chronic itch remains a highly prevalent disorder with limited treatment options. Most chronic itch diseases are thought to be driven by both the nervous and immune systems, but the fundamental molecular and cellular interactions that trigger the deve
Externí odkaz:
https://doaj.org/article/0278c3cd974b42de9fff49837b00bc9c
Autor:
Jehan Alladina, Neal P. Smith, Tristan Kooistra, Kamil Slowikowski, Isabela J. Kernin, Jacques Deguine, Henry L. Keen, Kasidet Manakongtreecheep, Jessica Tantivit, Rod A. Rahimi, Susan L. Sheng, Nhan D. Nguyen, Alexis M. Haring, Francesca L. Giacona, Lida P. Hariri, Ramnik J. Xavier, Andrew D. Luster, Alexandra-Chloé Villani, Josalyn L. Cho, Benjamin D. Medoff
Publikováno v:
Science Immunology. 8
Asthma is a chronic disease most commonly associated with allergy and type 2 inflammation. However, the mechanisms that link airway inflammation to the structural changes that define asthma are incompletely understood. Using a human model of allergen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bac21e1ceafad0c752193c03305d44e3
https://doi.org/10.1126/sciimmunol.abq6352
https://doi.org/10.1126/sciimmunol.abq6352
Autor:
Johannes F. Scheid, Basak Eraslan, Andrew Hudak, Eric M. Brown, Dallis Sergio, Toni M. Delorey, Devan Phillips, Ariel Lefkovith, Alison T. Jess, Lennard W. Duck, Charles O. Elson, Hera Vlamakis, Damian R. Plichta, Jacques Deguine, Ashwin N. Ananthakrishnan, Daniel B. Graham, Aviv Regev, Ramnik J. Xavier
Publikováno v:
Journal of Experimental Medicine. 220
Plasma cells (PCs) constitute a significant fraction of colonic mucosal cells and contribute to inflammatory infiltrates in ulcerative colitis (UC). While gut PCs secrete bacteria-targeting IgA antibodies, their role in UC pathogenesis is unknown. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51c9524b9243391c2f98718d67bd111c
https://doi.org/10.1084/jem.20220538
https://doi.org/10.1084/jem.20220538
Autor:
Basak Eraslan, Eric Brown, Maura Benson, Liat Amir-Zilberstein, Sung-Moo Park, Betsabeh Tusi, Vladislav Pokatayev, Cody Hecht, Novalia Pishesha, Devan Phillips, Andy Kim, Shuting Zhang, Anthony Gaca, Fadi Ghantous, Toni Delorey, Jonathan Livny, Lindsey Baden, Orit Rozenblatt-Rosen, Daniel Graham, Aviv Regev, Michael Seaman, Ann Woolley, Lisa Cosimi, Deborah Hung, Jacques Deguine, Ramnik Xavier
Publikováno v:
Research square.
SARS-CoV-2 infection leads to a broad range of outcomes and immune responses, with the development of neutralizing antibodies generally correlated with protection against reinfection. Here, we have characterized both neutralizing activity and T cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4b16e633205b8e33319dab6beab71b8
https://pubmed.ncbi.nlm.nih.gov/35313592
https://pubmed.ncbi.nlm.nih.gov/35313592
Autor:
Lingjia Kong, Vladislav Pokatayev, Ariel Lefkovith, Grace T. Carter, Elizabeth A. Creasey, Chirag Krishna, Sathish Subramanian, Bharati Kochar, Orr Ashenberg, Helena Lau, Ashwin N. Ananthakrishnan, Daniel B. Graham, Jacques Deguine, Ramnik J. Xavier
Publikováno v:
Immunity. 56:444-458.e5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ee4171f12e8c316a39c7fc6fe131ca4
https://doi.org/10.1016/j.immuni.2023.01.002
https://doi.org/10.1016/j.immuni.2023.01.002
Autor:
Lisa A. Cosimi, Betsabeh Khoramian Tusi, Yiska Weisblum, Kathryn E. Huey-Tubman, Andrew Hudak, Alexander A. Cohen, Orit Rozenblatt-Rosen, Lindsey R. Baden, Aviv Regev, Kara Rzasa, Frauke Muecksch, Michael S. Seaman, Xiebin Gu, Christopher O. Barnes, Jennifer R. Keeffe, Ann E. Woolley, Paul D. Bieniasz, Michael A Durney, Priyanthi N. P. Gnanapragasam, Toni Delorey, Anthony P. West, Pamela J. Bjorkman, Sung-Moo Park, Devan Phillips, Takuya Tada, Fadi Ghantous, Johannes Scheid, Deborah T. Hung, Shuting Zhang, Nathaniel R. Landau, Ramnik J. Xavier, Jacques Deguine, Daniel B. Graham, Basak Eraslan, Eric M. Brown, Theodora Hatziioanno
Publikováno v:
Cell
Monoclonal antibodies (mAbs) are a focus in vaccine and therapeutic design to counteract SARS-CoV-2 and its variants. Here, we combined B cell sorting with single-cell VDJ and RNA-seq and mAb structures to characterize B cell responses against SARS-C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1620e23fa39fd9c246a23789249c7917
https://resolver.caltech.edu/CaltechAUTHORS:20210429-090704273
https://resolver.caltech.edu/CaltechAUTHORS:20210429-090704273
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950), vol 198, iss 7
Neutrophils are generally the first immune cells recruited during the development of sterile or microbial inflammation. As these cells express many innate immune receptors with the potential to directly recognize microbial or endogenous signals, we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc5284109c912b4f1579b309707ad58
https://doi.org/10.4049/jimmunol.1601465
https://doi.org/10.4049/jimmunol.1601465
Autor:
Jessica Wei, Jamie Schwendinger-Schreck, Rachel B. Brem, Carolyn M Walsh, Karsten Gronert, Jacques Deguine, Rose Z Hill, Natalie Kucirek, Ziad Rifi, Emily C Brock, Diana M. Bautista, Gregory M. Barton
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3452ca6935c133dfb86ee801cb0d56be
https://doi.org/10.7554/elife.48448.sa2
https://doi.org/10.7554/elife.48448.sa2