Optimizing human in vivo dosing and delivery of ß-alanine supplements for muscle carnosine synthesis

Autor: Trent Stellingwerff, Roger Harris, Jacques Décombaz, Chris Boesch

Publikováno v: Amino acids
Stellingwerff, Trent; Decombaz, Jacques; Harris, Roger C; Boesch, Chris (2012). Optimizing human in vivo dosing and delivery of β-alanine supplements for muscle carnosine synthesis. Amino acids, 43(1), pp. 57-65. Wien: Springer 10.1007/s00726-012-1245-7

Interest into the effects of carnosine on cellular metabolism is rapidly expanding. The first study to demonstrate in humans that chronic β-alanine (BA) supplementation (~3-6 g BA/day for ~4 weeks) can result in significantly augmented muscle carnos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40df034bc6248cafcb596dbf1ae64170

Effect of two β-alanine dosing protocols on muscle carnosine synthesis and washout

Autor: Helen Anwander, Roland Kreis, Jacques Décombaz, Tania Buehler, Trent Stellingwerff, Chris Boesch, Andrea Egger

Publikováno v: Stellingwerff, Trent; Anwander, Helen; Egger, Andrea; Buehler, Tania; Kreis, Roland; Decombaz, Jacques; Boesch, Chris (2012). Effect of two beta-alanine dosing protocols on muscle carnosine synthesis and washout. Amino acids, 42(6), pp. 2461-72. Wien: Springer 10.1007/s00726-011-1054-4
Amino acids

Carnosine (β-alanyl-L-histidine) is found in high concentrations in skeletal muscle and chronic β-alanine (BA) supplementation can increase carnosine content. This placebo-controlled, double-blind study compared two different 8-week BA dosing regim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33beec62b8989328c41c632796f2d21c
https://doi.org/10.1007/s00726-011-1054-4

Intramyocellular lipid stores increase markedly in athletes after 1.5 days lipid supplementation and are utilized during exercise in proportion to their content

Autor: Emanuel Christ, Jacques Décombaz, Kevin J. Acheson, Roland Kreis, Monica Zehnder, Roman Trepp, Etienne Pouteau, Chris Boesch, Michael Ith, Peter Diem

Publikováno v: Zehnder, Monica; Christ, Emanuel R; Ith, Michael; Acheson, Kevin J; Pouteau, Etienne; Kreis, Roland; Trepp, Roman; Diem, Peter; Boesch, Chris; Décombaz, Jacques (2006). Intramyocellular lipid stores increase markedly in athletes after 1.5 days lipid supplementation and are utilized during exercise in proportion to their content. European journal of applied physiology, 98(4), pp. 341-54. Heidelberg: Springer 10.1007/s00421-006-0279-5

Intramyocellular lipids (IMCL) and muscle glycogen provide local energy during exercise (EX). The objective of this study was to clarify the role of high versus low IMCL levels at equal initial muscle glycogen on fuel selection during EX. After 3 h o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::163db181705697fdaac53a65e1d99d68
https://doi.org/10.1007/s00421-006-0279-5

Interaction Between Dietary Lipids and Physical Inactivity on Insulin Sensitivity and on Intramyocellular Lipids in Healthy Men

Autor: Michael Ith, Christophe Binnert, Chris Boesch, Rodrigue Stettler, Kevin J. Acheson, Luc Tappy, Jacques Décombaz

Publikováno v: Diabetes Care. 28:1404-1409

OBJECTIVE—To assess the effect of a possible interaction between dietary fat and physical inactivity on whole-body insulin sensitivity and intramyocellular lipids (IMCLs). RESEARCH DESIGN AND METHODS—Eight healthy male volunteers were studied on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd018b93dbb53eb43ecfc8ddead9dfd
https://doi.org/10.2337/diacare.28.6.1404

Effect of short-duration lipid supplementation on fat oxidation during exercise and cycling performance

Autor: Dominik Grathwohl, Fabio Borrani, Philippe Pollien, Virgile Lecoultre, Jacques Décombaz, Jeroen A. J. Schmitt

Publikováno v: Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. 38(7)

The effect of intramyocellular lipids (IMCLs) on endurance performance with high skeletal muscle glycogen availability remains unclear. Previous work has shown that a lipid-supplemented high-carbohydrate (CHO) diet increases IMCLs while permitting no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2828356b38754f0d236b7d16376d6c6
https://pubmed.ncbi.nlm.nih.gov/23980735