Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Jacques Couquelet"'
Autor:
Christine Courteix, Catherine Rubat, Joseph Fialip, Pascal Coudert, Jacques Couquelet, Monique Bebot
Publikováno v:
Web of Science
A series of 5-[4-(arylpiperazin-1-yl)alkylamino]-4-benzyl-3-methy1-1,2-oxazin-6-ones was synthesized and evaluated for analgesic activity. The structures of these new oxazine derivatives were confirmed by IR, 1 H-NMR spectra and by elemental analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19406e06bf4d3cd6743de64fb5a0ca06
https://doi.org/10.1055/s-0031-1300214
https://doi.org/10.1055/s-0031-1300214
Autor:
Daniel Gardette, Jean Claude Gramain, M. Madesclaire, Eliane Duroux, Danielle Vallee-Goyet, Pascal Coudert, Fernand Leal, Marc Bria, Jacques Couquelet, Valérie Weber, Eliane Albuisson, Catherine Rubat
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:1647-1658
In order to study the effect of phenol moieties on biological activities of ascorbic acid derivatives, we synthesized 13 novel 4,5-diaryl-3-hydroxy-2(5H)-furanones 5a-m with various substitution patterns. Compound 5 g bearing a 2,3-dihydroxy phenyl r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f808ab58500372a1ad40de0f846d59a2
https://doi.org/10.1016/s0968-0896(02)00053-6
https://doi.org/10.1016/s0968-0896(02)00053-6
Autor:
Catherine Rubat, Eliane Duroux, Pascal Coudert, Jacques Couquelet, Fernand Leal, Valérie Weber
Publikováno v:
Journal of Pharmacy and Pharmacology. 52:523-530
Structural modifications of ascorbic acid by the introduction of lipophilic moieties has led to derivatives with increased stability against thermal and oxidative degradation. Two series of new lipophilic ascorbic analogues were synthesized to obtain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc7b86f93f33302938c7a532e58968c6
https://doi.org/10.1211/0022357001774318
https://doi.org/10.1211/0022357001774318
Publikováno v:
Chemistry of Heterocyclic Compounds. 35:474-478
The reaction of paraformaldehyde with (1S,2S)-2-aryl(hetaryl)methylamino-1-(4-nitrophenyl)-1,3-propanediols produces a mixture of isomeric 3-aryl(hetaryl)methyl-4-hydroxymethyl-5-(4-nitrophenyl)- and 3-aryl(hetary)methyl-4-hydroxy(4-nitrophenyl)methy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0189d6a144da054e5bc548f0c8637e71
https://doi.org/10.1007/bf02319337
https://doi.org/10.1007/bf02319337
Publikováno v:
Bioorganic & Medicinal Chemistry. 6:349-354
Four pyrrolo[1,2-d][1,2,4]triazines and four thiazolo[3,4-d][1,2,4]triazines were synthesized from trans-4-hydroxy-L-proline and L-thiaproline, respectively. The synthetic route involved formation of hydrazides followed by cyclization with orthoester
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bcb27447b2a13e29509c7cfd8126698
https://doi.org/10.1016/s0968-0896(97)10052-9
https://doi.org/10.1016/s0968-0896(97)10052-9
Publikováno v:
Chemical and Pharmaceutical Bulletin. 44:980-986
A series of 4,6-diaryl pyridazinones, chemically related to trazodone, ws synthesized and evaluated for analgesic activity. With ED50 values ranging from 8.4 to 46.7 mg kg(-1) i.p. in the phenylbenzoquinone-induced writhing test (PBQ test), most comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f075779c28b0a923dcb9c37e41323286
https://doi.org/10.1248/cpb.44.980
https://doi.org/10.1248/cpb.44.980
Publikováno v:
European Journal of Medicinal Chemistry. 31:717-723
Summary In order to improve the water solubility of some previously reported immunoactive dioxothiadiazabicyclo[3.3.0]octanes, we synthesized a series of new diazabicyclo[3.3.0]octanols from the trans -4-hydroxy- l -proline methyl ester in two steps.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2aa7dcc09e783c86fd18d929b4a2624d
https://doi.org/10.1016/0223-5234(96)85881-8
https://doi.org/10.1016/0223-5234(96)85881-8
Publikováno v:
Pharmaceutica Acta Helvetiae. 69:29-37
The CNS activities of thirteen triazaspirodecanediones have been compared by multivariate statistical analysis. The response parameters used in this study were spontaneous motor activity, potentiation of pentobarbital effect, anticonvulsant and anxio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5932554dbd5bc87b2edbe1956e0b3b05
https://doi.org/10.1016/0031-6865(94)90028-0
https://doi.org/10.1016/0031-6865(94)90028-0
Publikováno v:
Journal of Heterocyclic Chemistry. 31:77-80
Thiazolidine-2,4-dicarboxylic acid 2 was obtained as a diastereoisomeric mixture from the condensation of glyoxylic acid with L(-)R-cysteine 1. In solution behaviour studies suggested that the reaction proceeded through an acid catalyzed epimerizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44e3939861b40d5fc36216583dcf030c
https://doi.org/10.1002/jhet.5570310114
https://doi.org/10.1002/jhet.5570310114
Autor:
Laurence Nicod, S. Harraga, Jean-François Robert, P. Tronche, Bernard Refouvelet, E. Seilles, Jacques Couquelet
Publikováno v:
Chemical and Pharmaceutical Bulletin
Chemical and Pharmaceutical Bulletin, Pharmaceutical Society of Japan, 1994, 42 (5), pp.1076-1083
Chemical and Pharmaceutical Bulletin, Pharmaceutical Society of Japan, 1994, 42 (5), pp.1076-1083
International audience; A series of 6,8-dioxo-3-thia-1,7-diazabicyclo[3.3.0]octanes and a series of 6,8-dioxo-3-thia-1,7-diazabicyclo[3.3.0]octane 2-spiro derivatives were synthesized from L-(-)-R-cysteine ethyl ester in two steps. The synthetic rout
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5aa24700665d3524ea93e0e553c02a3
https://doi.org/10.1248/cpb.42.1076
https://doi.org/10.1248/cpb.42.1076