Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jacques Cercus"'
Autor:
Herbert Mühle, Joachim Nozulak, Jacques Cercus, Ernst Küsters, Ulrich Beutler, Gerhard Penn, Werner Zaugg
Publikováno v:
CHIMIA, Vol 50, Iss 5 (1996)
cis-4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]naphthyridine (rac-4) (SDZ SER-082) is a selective and potent 5-HT2C/2B receptor antagonist, exerting weak affinity towards the 5-HT2A receptor site. The compound 4 was found to be a
Externí odkaz:
https://doaj.org/article/24902d95c9ae4a5a82a9b258e18f8a68
Publikováno v:
Organic Process Research & Development. 9:259-271
Herein, we report the formal synthesis of (+)-discodermolide (1), a promising anticancer agent of sponge origin, in 24 linear steps, with 35 steps in total. The route proceeds from lactone 2, a building block containing the common 1,2-anti-2,3-syn st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c37e82d46087e648abdf313c8e0b2b58
https://doi.org/10.1021/op049807s
https://doi.org/10.1021/op049807s
Autor:
Gottfried Sedelmeier, Xu David, Thomas Allmendinger, Olivier Loiseleur, Murat Acemoglu, Calienni John Vincent, Jacques Cercus
Publikováno v:
Tetrahedron. 60:11571-11586
Various new N-aryl oxindoles were synthesized as intermediates for the preparation of pharmacologically active 2-(N-arylamino)-phenylacetic acids. Two novel approaches were explored for the construction of diarylamine and N-aryl oxindole core structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0da4ec04d41a36f1113f675d7905f54
https://doi.org/10.1016/j.tet.2004.09.064
https://doi.org/10.1016/j.tet.2004.09.064
Autor:
Wen-Chung Shieh, Robert Daeffler, Run-Ming Wang, Remo Gamboni, Song Xue, Friedrich Schuerch, Loeser Eric M, Gordon Florence and, Ian Paterson, Guang-Pei Chen, Daniel Niederer, Adnan Osmani, Frederick Ray Kinder, Kapa Prasad, Joseph Mckenna, Jacques Cercus, Klaus Schreiner, Gottfried Sedelmeier, Manuela Seger, Olivier Loiseleur, Kurt Königsberger, Timothy Michael Ramsey, Larry Rogers, Andrew Bach, Oljan Repic, Weichun Chen, Noela Reel, Dominique Bixel, Peng Geng, and Liladhar Waykole, and Karl Schaer, Stuart J. Mickel, Hans Stettler, George T. Lee
Publikováno v:
Organic Process Research & Development. 8:113-121
Coupling of C9-14 (4) and C15-21 (5a) fragments to produce the cis-trisubstituted olefin was achieved using Suzuki-type coupling conditions employed by Marshall (5a/tert-BuLi/B-OMe-9-BBN added to 4/Cs2CO3/Pd(dppf)2). The terminal (Z)-diene moiety was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::636e79cabb468b439dd0390f88424064
https://doi.org/10.1021/op034133r
https://doi.org/10.1021/op034133r
Autor:
Markus Bänziger, Hans Hirt, Christophe Malan, Kurt Laumen, Troxler Thomas J, Felix Spindler, Jacques Cercus, Fritz Struber
Publikováno v:
Tetrahedron: Asymmetry. 14:3469-3477
The decahydroisoquinoline derivative NVP-ACQ090 is a potent and selective antagonist at the somatostatin sst3 receptor. The original research synthesis of NVP-ACQ090 comprises a main chain of nine linear steps and two side chains of three and steps,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26306db1c8d1fba3cf32e2702b077d42
https://doi.org/10.1016/j.tetasy.2003.07.024
https://doi.org/10.1016/j.tetasy.2003.07.024
Publikováno v:
Organic Process Research & Development. 4:460-466
3- Substituted octahydrobenzo[g]quinolines are important intermediates for pharmaceutically active compounds. A short, efficient synthesis, which is feasible for large-scale manufacturing of rac-(3S,4aR,10aR)-6-methoxy-1-propyl-1,2,3,4,4a,5,10,10a-oc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a4adbc9a3950e206e3e5218bba8f5c2
https://doi.org/10.1021/op0000531
https://doi.org/10.1021/op0000531
Publikováno v:
ChemInform. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3612e3be4628456a17841520a2dd8aee
https://doi.org/10.1002/chin.200115140
https://doi.org/10.1002/chin.200115140
Autor:
Herbert Mühle, Joachim Nozulak, Jacques Cercus, Ernst Küsters, Ulrich Beutler, Gerhard Penn, Werner Zaugg
Publikováno v:
CHIMIA, Vol 50, Iss 5 (1996)
cis-4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]naphthyridine (rac-4) (SDZ SER-082) is a selective and potent 5-HT2C/2B receptor antagonist, exerting weak affinity towards the 5-HT2A receptor site. The compound 4 was found to be a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8e37dd81ec7f7b16e9e78ee98e51d1
https://doi.org/10.2533/chimia.1996.209
https://doi.org/10.2533/chimia.1996.209
Autor:
Hans Braunschweiger, Silvio Roggo, Jacques Cercus, Dieter Seebach, Thomas Maetzke, Manfred Krieger
Publikováno v:
Helvetica Chimica Acta. 70:1605-1615
Diastereo- and Enantioselective Reduction of beta;-Keto Esters Derived from Cyclopentanone, Cyclohexanone, Piperidone and Tetralone by ‘Non-fermenting’ Baker's Yeast Under ‘non-fermenting’ conditions, i.e. in tap water, in the absence of nutr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60e88b3fdbd9c344148df091b83c4b1a
https://doi.org/10.1002/hlca.19870700618
https://doi.org/10.1002/hlca.19870700618