Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jacques C Mbongue"'
Autor:
Nan-Sun Kim, Jacques C Mbongue, Dequina A Nicholas, Grace E Esebanmen, Juli J Unternaehrer, Anthony F Firek, William H R Langridge
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0147509 (2016)
A chimeric protein vaccine composed of the cholera toxin B subunit fused to proinsulin (CTB-INS) was shown to suppress type 1 diabetes onset in NOD mice and upregulate biosynthesis of the tryptophan catabolic enzyme indoleamine 2, 3-dioxygenase (IDO1
Externí odkaz:
https://doaj.org/article/ef6a1bb7a8324ebfaa37b98734ab72e7
Autor:
Jacques C Mbongue, Dequina A Nicholas, Kangling Zhang, Nan-Sun Kim, Brittany N Hamilton, Marco Larios, Guangyu Zhang, Kazuo Umezawa, Anthony F Firek, William H R Langridge
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0118562 (2015)
Dendritic cells (DC) interact with naïve T cells to regulate the delicate balance between immunity and tolerance required to maintain immunological homeostasis. In this study, immature human dendritic cells (iDC) were inoculated with a chimeric fusi
Externí odkaz:
https://doaj.org/article/bfd8079b8ab3400d823e6395638e5f63
Autor:
Dequina A. Nicholas, Jacques C. Mbongue, Darysbel Garcia-Pérez, Dane Sorensen, Heather Ferguson Bennit, Marino De Leon, William H. R. Langridge
Publikováno v:
Immuno, Vol 4, Iss 1, Pp 91-107 (2024)
Around 285 million people worldwide currently have type 2 diabetes and it is projected that this number will be surpassed by 2030. Therefore, it is of the utmost importance to enhance our comprehension of the disease’s development. The regulation o
Externí odkaz:
https://doaj.org/article/38fba84317d249d6bee16decbb9ae187
Publikováno v:
Immuno, Vol 3, Iss 2, Pp 217-227 (2023)
The 19th century saw the development of vaccines, which were biological preparations designed to enhance immunity against specific diseases. Edible vaccines function by stimulating both systemic and mucosal immune responses against foreign pathogens,
Externí odkaz:
https://doaj.org/article/5675089225204db1b6b5b52ff7abb41c
Publikováno v:
Immuno. 2:482-500
Bacterial lipopolysaccharides (LPS), also referred to as endotoxins, are major outer surface membrane components present on almost all Gram-negative bacteria and are major determinants of sepsis-related clinical complications including septic shock.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e70ae21eb1a5aa7c307035041cbaed1d
https://doi.org/10.3390/immuno2030030
https://doi.org/10.3390/immuno2030030
Autor:
Jacques C. Mbongue, Dequina A. Nicholas, Timothy W. Torrez, Nan-Sun Kim, Anthony F. Firek, William H.R. Langridge
Publikováno v:
Vaccines, Vol 3, Iss 3, Pp 703-729 (2015)
Indoleamine 2, 3-dioxygenase (IDO) is the first and rate limiting catabolic enzyme in the degradation pathway of the essential amino acid tryptophan. By cleaving the aromatic indole ring of tryptophan, IDO initiates the production of a variety of try
Externí odkaz:
https://doaj.org/article/996e5456eb0541558420f62c530cb9fd
Autor:
Jacques C. Mbongue, Pablo A. Garcia, Mohamed I. Husseiny, Ali Alhoshani, Jeffrey Rawson, Fouad Kandeel, Nelson Gonzalez, Kevin Ferreri
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Type 1 diabetes (T1D) arises secondary to immune-driven destruction of pancreatic β-cells and manifests as insulin-deficient hyperglycemia. We showed that oral vaccination with live attenuated Salmonella, which simultaneously delivers autoantigens a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b58fbaa22f699f8f91e7d48418818f6
https://www.frontiersin.org/article/10.3389/fimmu.2020.00712/full
https://www.frontiersin.org/article/10.3389/fimmu.2020.00712/full
Autor:
Pablo A. Garcia, Nelson Gonzalez, Fouad Kandeel, Mohamed I. Husseiny, Jacob Cobb, Kevin Ferreri, Jacques C. Mbongue, Jeffrey Rawson
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Autoimmune diseases such as type 1 diabetes (T1D) involve the loss of regulatory mechanisms resulting in increased tissue-specific cytotoxicity. The result is destruction of pancreatic insulin-producing β-cells and loss of glucose homeostasis. We ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a37e44e1bcdc3ad46985d6c5a5ee17
https://www.frontiersin.org/article/10.3389/fimmu.2019.00320/full
https://www.frontiersin.org/article/10.3389/fimmu.2019.00320/full
Autor:
Jacques C, Mbongue, Jeffrey, Rawson, Pablo A, Garcia, Nelson, Gonzalez, Jacob, Cobb, Fouad, Kandeel, Kevin, Ferreri, Mohamed I, Husseiny
Publikováno v:
Frontiers in Immunology
Autoimmune diseases such as type 1 diabetes (T1D) involve the loss of regulatory mechanisms resulting in increased tissue-specific cytotoxicity. The result is destruction of pancreatic insulin-producing β-cells and loss of glucose homeostasis. We ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::57781735114cf1b4872a20075ba90b8b
https://pubmed.ncbi.nlm.nih.gov/30863412
https://pubmed.ncbi.nlm.nih.gov/30863412
Autor:
Ayelet Lenz, Jeffrey Rawson, Mohamed I. Husseiny, Fouad Kandeel, Kevin Ferreri, Weiting Du, Jacques C. Mbongue
Publikováno v:
Vaccine. 36(52)
We previously reported the development of an oral vaccine for diabetes based on live attenuated Salmonella-expressing preproinsulin (PPI) as the autoantigen. When combined with host cell-expressed TGFβ, the vaccine prevented the onset of diabetes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c5d70aa315be2ad14bf92b6a1e7995
https://pubmed.ncbi.nlm.nih.gov/30416020
https://pubmed.ncbi.nlm.nih.gov/30416020