Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jacques C, Migeon"'
Publikováno v:
Molecular Biology of the Cell. 10:1733-1744
We identified a new Drosophila gene, peter pan (ppan), in a screen for larval growth–defective mutants. ppan mutant larvae do not grow and show minimal DNA replication but can survive until well after their heterozygotic siblings have pupariated. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67f6d6029f74fb352920b0e750f9929
https://doi.org/10.1091/mbc.10.6.1733
https://doi.org/10.1091/mbc.10.6.1733
Publikováno v:
Annals of the New York Academy of Sciences. 757:180-185
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2264d8799a320dbb9b89f462b1f21f08
https://doi.org/10.1111/j.1749-6632.1995.tb17473.x
https://doi.org/10.1111/j.1749-6632.1995.tb17473.x
Autor:
Phyllis S. Goldman, Neil M. Nathanson, Lise A. McKinnon, Darrell A. Jackson, Jacques C. Migeon, Sarabeth L. Thomas, Beth A. Habecker, Susan E. Hamilton
Publikováno v:
Life Sciences. 56:939-943
We have investigated the molecular mechanisms involved in the regulation of muscarinic acetylcholine receptor gene expression and localization and generated knockout mice to study the role of the M1 muscarinic receptor in vivo. We have used the MDCK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63491c51bdb17da5f280b07a59fb9663
https://doi.org/10.1016/0024-3205(95)00031-z
https://doi.org/10.1016/0024-3205(95)00031-z
Publikováno v:
Journal of Biological Chemistry. 269:29146-29152
We have used a luciferase reporter gene under the transcriptional control of a cAMP response element (CRE) to monitor the effects of G-protein alpha subunits on cAMP-regulated gene expression and to examine muscarinic acetylcholine receptor (mAChR) f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db9612dc454f82a7628ac0a766f26dbf
https://doi.org/10.1016/s0021-9258(19)62023-5
https://doi.org/10.1016/s0021-9258(19)62023-5
Autor:
Neil M. Nathanson, Jacques C. Migeon
Publikováno v:
Journal of Biological Chemistry. 269:9767-9773
We have used a luciferase reporter gene under the transcriptional control of a cAMP response element as a sensitive monitor of the regulation by muscarinic acetylcholine receptors (mAChRs) of intracellular cAMP levels and cAMP-regulated gene expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef2afe940fc54bfabb28507fb7e4895e
https://doi.org/10.1016/s0021-9258(17)36949-1
https://doi.org/10.1016/s0021-9258(17)36949-1
Autor:
Lise A. Parenteau, Kathleen M. Tietje, Phyllis S. Goldman, Chris J. van Koppen, Beth A. Habecker, Sharon A. Creason, Neil M. Nathanson, Jacques C. Migeon
Publikováno v:
Life Sciences. 52:429-432
The regulation of expression and function of the muscarinic acetylcholine receptor has been studied using several different systems. The role of glycosylation of the m2 receptor was examined by removal of glycosylation sites using site-directed mutag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8bddb6288fcfe1037c6e9f70d0fd0cf
https://doi.org/10.1016/0024-3205(93)90298-h
https://doi.org/10.1016/0024-3205(93)90298-h
Autor:
Gary Yellen, Jacques C. Migeon
Publikováno v:
Gene. 86:145-152
We have produced the four subunits of the nicotinic acetylcholine receptor of Torpedo californica, an integral membrane protein, in the yeast Saccharomyces cerevisiae. Two of the subunits (alpha and delta) were readily produced from their cDNAs after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0241b51bf74c3d787221ba80561a93cf
https://doi.org/10.1016/0378-1119(90)90273-t
https://doi.org/10.1016/0378-1119(90)90273-t
Autor:
Cecile M, Krejsa, Dragos, Horvath, Sherri L, Rogalski, Julie E, Penzotti, Boryeu, Mao, Frédérique, Barbosa, Jacques C, Migeon
Publikováno v:
Current opinion in drug discoverydevelopment. 6(4)
Computational methods are increasingly used to streamline and enhance the lead discovery and optimization process. However, accurate prediction of absorption, distribution, metabolism and excretion (ADME) and adverse drug reactions (ADR) is often dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0bcd7ce6338b86dfc9f5255b2c50ec38
https://pubmed.ncbi.nlm.nih.gov/12951810
https://pubmed.ncbi.nlm.nih.gov/12951810
Publikováno v:
The American journal of physiology. 277(6)
We have characterized the muscarinic ACh receptors (mAChRs) expressed in Madin- Darby canine kidney (MDCK) strain II epithelial cells. Binding studies with the membrane-impermeable antagonist N-[3H]methylscopolamine demonstrated that mAChRs are ∼2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2b4d1a6dc671fb2844f3f01fad5023
https://pubmed.ncbi.nlm.nih.gov/10600774
https://pubmed.ncbi.nlm.nih.gov/10600774
Publikováno v:
The Journal of biological chemistry. 270(27)
We compared the G-protein requirements for coupling of human and chicken m2 and m4 muscarinic acetylcholine receptors (mAChRs) to inhibition of adenylyl cyclase, using a luciferase reporter gene under the transcriptional control of a cAMP response el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28097c437f7a66162977961ff0b70919
https://pubmed.ncbi.nlm.nih.gov/7608168
https://pubmed.ncbi.nlm.nih.gov/7608168