Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Jacques Briand"'
Autor:
Gaochao Tian, Steven R. Katchur, Yong Jiang, Jacques Briand, Michael Schaber, Constantine Kreatsoulas, Benjamin Schwartz, Sara Thrall, Alicia M. Davis, Sam Duvall, Brett A. Kaufman, William L. Rumsey
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract 8-Oxoguanine DNA glycosylase (OGG1) initiates base excision repair of the oxidative DNA damage product 8-oxoguanine. OGG1 is bifunctional; catalyzing glycosyl bond cleavage, followed by phosphodiester backbone incision via a β-elimination a
Externí odkaz:
https://doaj.org/article/6865606e68fe4a83a2797cb46fc67eee
Autor:
Peter A. Jones, Ashley K. Wiseman, Helai P. Mohammad, Christopher S. Kershaw, Bryan W. King, Ian D. Waddell, Thau F. Ho, Stephen B. Baylin, Morris Muliaditan, Marcus Bantscheff, Elisabeth A. Minthorn, Thilo Werner, Alan P. Graves, Wendy A. Kellner, Phil Chapman, Mehul Patel, Anthony J. Jurewicz, Allan M. Jordan, Emma E. Fairweather, Rab K. Prinjha, Nino Campobasso, Anna Rutkowska, H. Christian Eberl, Ryan G. Kruger, Charles F. McHugh, Michael T. McCabe, Kristin M. Goldberg, Jon Paul Jaworski, Christopher L. Carpenter, Michael Steidel, Stuart Paul Romeril, Dirk A. Heerding, Lourdes Rueda, David T. Fosbenner, Amy N. Taylor, Jacques Briand, Shawn W. Foley, Arthur Groy, Andrew B. Benowitz, Xiaodong Cheng, Donald J. Ogilvie, Paola Grandi, Cunyu Zhang, Mei Li, Sarath Pathuri, Aidan G. Gilmartin, Christian S. Sherk, Juan I. Luengo, Mark Cockerill, Ali Raoof, Alexandra Stowell, Kathryn Keenan, Melissa B. Pappalardi, Makda Mebrahtu, Kristen Wong, Xing Zhang, Jessica L. Handler, Roger J. Butlin, John R. Horton, Susan Merrihew, Charlotte Burt, Dean E. McNulty
Publikováno v:
Nature Cancer. 2:1002-1017
DNA methylation, a key epigenetic driver of transcriptional silencing, is universally dysregulated in cancer. Reversal of DNA methylation by hypomethylating agents, such as the cytidine analogs decitabine or azacytidine, has demonstrated clinical ben
Autor:
Gaochao Tian, Steven Katchur, Yong Jiang, Jacques Briand, Michael Schaber, Constantine Kreatsoulas, Benjamin Schwartz, Sara Thrall, Alicia Davis, Sam Duvall, Brett Kaufman, William Rumsey
8-Oxoguanine DNA glycosylase (OGG1) initiates base excision repair of the oxidative DNA damage product 8-oxoguanine. OGG1 is bifunctional; catalyzing glycosyl bond cleavage, followed by phosphodiester backbone incision via a β-elimination apurinic l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cf3fcdf75087760c207faf2a8a930eb
https://doi.org/10.21203/rs.3.rs-1786284/v1
https://doi.org/10.21203/rs.3.rs-1786284/v1
Autor:
John J. McAtee, Jacques Briand, David J. Behm, Karl F. Erhard, Andrew D. Roberts, Ralph A. Rivero, Brian G. Lawhorn, Joseph E. Pero, Grazyna Graczyk-Millbrandt, Dennis A. Holt
Publikováno v:
ACS Med Chem Lett
[Image: see text] GSK2798745, an antagonist of the transient receptor potential vanilloid 4 (TRPV4) ion channel, was recently investigated in clinical trials for the treatment of cardiac and respiratory diseases. Human plasma and urine samples collec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b6d51b5ede72ceaac42c737d6c5900d
https://europepmc.org/articles/PMC8436415/
https://europepmc.org/articles/PMC8436415/
Autor:
Mary Ann Hardwicke, Hong Lin, Karl F. Erhard, John D. Martin, Ren Xie, Kaushik Raha, Rosanna Tedesco, Jin Zeng, Yanqiu Qian, Patricia M. Kratz, Yong Jiang, Ted Cecconie, Stan F. Martens, Angela Smallwood, Patrick McDevitt, James F. Mack, Baoguang Zhao, Stephenie B. Chen, Anthony J. Jurewicz, Juan I. Luengo, Mark J. Schulz, Nino Campobasso, Catherine A. Oleykowski, Lawrence M. Szewczuk, Alan R. Rendina, Cynthia M. Rominger, Benjamin J. Schwartz, Leng Nickels, Junya Qu, Jacques Briand
Publikováno v:
ACS Medicinal Chemistry Letters. 7:217-222
A novel series of potent and selective hexokinase 2 (HK2) inhibitors, 2,6-disubstituted glucosamines, has been identified based on HTS hits, exemplified by compound 1. Inhibitor-bound crystal structures revealed that the HK2 enzyme could adopt an "in
Autor:
Michael L. Moore, Liping Wang, Mary Ann Hardwicke, Kristin K. Brown, Rachel D. Totoritis, William Burkhart, Ramona Plant, Shawn P. Williams, Guofeng Zhang, Alan R. Rendina, Cynthia A. Parrish, Julie A. Krueger, Jacques Briand
Publikováno v:
Nature Chemical Biology. 10:774-779
Human fatty acid synthase (hFAS) is a complex, multifunctional enzyme that is solely responsible for the de novo synthesis of long chain fatty acids. hFAS is highly expressed in a number of cancers, with low expression observed in most normal tissues
Autor:
Kristen Wong, Jessica L. Handler, Michael T. McCabe, Helai P. Mohammad, Bryan W. King, Dirk A. Heerding, Melissa B. Pappalardi, Ryan G. Kruger, Lourdes Rueda, Mehul Patel, David T. Fosbenner, Allan M. Jordan, Elisabeth A. Minthorn, Andrew B. Benowitz, Kathryn Keenan, Christian S. Sherk, Ali Raoof, Charlotte Burt, Alexandra Stowell, Mark Cockerill, Jacques Briand, Charles F. McHugh, Rab K. Prinjha
Publikováno v:
Cancer Research. 78:2994-2994
Aberrant DNA hypermethylation within promoter regions and subsequent gene silencing are near universal hallmarks of human cancer. Reversal of DNA methylation by a hypomethylating agent, such as decitabine (Dacogen) or azacytidine (Vidaza), has shown
Autor:
David G. Tew, Mark Alan Levy, Thaddeus A. Tomaszek, Thomas D. Meek, Daniel F. Veber, Stacie Halpert, Michael J. Huddleston, Steven A. Carr, Carl F. Ijames, Jacques Briand, Scott K. Thompson, Mary J. Bossard
Publikováno v:
Biochemistry. 38:15893-15902
The nature of the inhibition of thiol proteases by a new class of mechanism-based inhibitors, 1,5-diacylcarbohydrazides, is described. These potent, time-dependent, active-site spanning inhibitors include compounds that are selective for cathepsin K,
Publikováno v:
Journal of Magnetic Resonance. 139:443-446
A novel multidimensional NMR pulse sequence tool, spin-state-selective time-proportional phase incrementation (S(3) TPPI), is introduced. It amounts to application of different TPPIs on the two components of doublets so that their frequencies can be
Publikováno v:
Molecular Physics. 95:1137-1142
The spin-state-selective coherence transfer (S3CT) pulse sequence element has earlier been introduced as a means of editing the two resonances of a doublet (S⊘rensen, M. D., et al. 1997, J. Biomol. NMR, 10, 181). This paper demonstrates how two con