Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis.

Autor: Alexandra-Chloé Villani, Mathieu Lemire, Edouard Louis, Mark S Silverberg, Catherine Collette, Geneviève Fortin, Elaine R Nimmo, Yannick Renaud, Sébastien Brunet, Cécile Libioulle, Jacques Belaiche, Alain Bitton, Daniel Gaudet, Albert Cohen, Diane Langelier, John D Rioux, Ian D R Arnott, Gary E Wild, Paul Rutgeerts, Jack Satsangi, Séverine Vermeire, Thomas J Hudson, Denis Franchimont

Publikováno v: PLoS ONE, Vol 4, Iss 9, p e7154 (2009)

The familial Mediterranean fever (FMF) gene (MEFV) encodes pyrin, a major regulator of the inflammasome platform controlling caspase-1 activation and IL-1beta processing. Pyrin has been shown to interact with the gene product of NLRP3, NALP3/cryopyri

Externí odkaz: https://doaj.org/article/dd0119c4b4a24805b544a4aa771cbfb2

Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4.

Autor: Cécile Libioulle, Edouard Louis, Sarah Hansoul, Cynthia Sandor, Frédéric Farnir, Denis Franchimont, Séverine Vermeire, Olivier Dewit, Martine de Vos, Anna Dixon, Bruno Demarche, Ivo Gut, Simon Heath, Mario Foglio, Liming Liang, Debby Laukens, Myriam Mni, Diana Zelenika, André Van Gossum, Paul Rutgeerts, Jacques Belaiche, Mark Lathrop, Michel Georges

Publikováno v: PLoS Genetics, Vol 3, Iss 4, p e58 (2007)

To identify novel susceptibility loci for Crohn disease (CD), we undertook a genome-wide association study with more than 300,000 SNPs characterized in 547 patients and 928 controls. We found three chromosome regions that provided evidence of disease

Externí odkaz: https://doaj.org/article/14badae124fb4fb19fb28982d2905bee

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

Autor: Jerome I. Rotter, Elaine R. Nimmo, Jeffrey C. Barrett, Jacques Belaiche, Cynthia Sandor, Martine De Vos, Natalie J. Prescott, Mark J. Daly, André Van Gossum, Dan L. Nicolae, Alain Bitton, A. Hillary Steinhart, Christopher G. Mathew, Rhian Gwilliam, L. Philip Schumm, M. Michael Barmada, Panos Deloukas, Olivier Dewit, Severine Vermeire, Debby Laukens, Miguel Regueiro, Edouard Louis, Kent D. Taylor, Cécile Libioulle, Jonathan Marchini, Carl A. Anderson, Emily O. Kistner, Judy H. Cho, John D. Rioux, Simon Heath, Clive M. Onnie, Themistocles Dassopoulos, John C. Mansfield, Myriam Mni, Jack Satsangi, Mark Tremelling, Jean-Pierre Hugot, Hazel E. Drummond, Ramnik J. Xavier, Mark Lathrop, Michel Georges, Steven R. Brant, Lon R. Cardon, Miles Parkes, Jilur Ghori, Tariq Ahmad, Michael T. Murtha, Mark S. Silverberg, Stephan R. Targan, Suzannah Bumpstead, Ivo Gut, Todd Green, Derek P. Jewell, Richard H. Duerr, Denis Franchimont, Paul Rutgeerts, Anne M. Griffiths, Sarah Hansoul, Diana Zelenika, Sheila A. Fisher, Lisa W. Datta

Publikováno v: Barrett, J C, Hansoul, S, Nicolae, D L, Cho, J H, Duerr, R H, Rioux, J D, Brant, S R, Silverberg, M S, Taylor, K D, Barmada, M M, Bitton, A, Dassopoulos, T, Datta, L W, Green, T, Griffiths, A M, Kistner, E O, Murtha, M T, Regueiro, M D, Rotter, J I, Schumm, L P, Steinhart, A H, Targan, S R, Xavier, R J, Libioulle, C, Sandor, C, Lathrop, M, Belaiche, J, Dewit, O, Gut, I, Heath, S, Laukens, D, Mni, M, Rutgeerts, P, Van Gossum, A, Zelenika, D, Franchimont, D, Hugot, J-P, de Vos, M, Vermeire, S, Louis, E, Cardon, L R, Anderson, C A, Drummond, H, Nimmo, E, Ahmad, T, Prescott, N J, Onnie, C M, Fisher, S A, Marchini, J, Satsangi, J 2008, ' Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease ', Nature Genetics, vol. 40, no. 8, pp. 955-962 . https://doi.org/10.1038/ng.175

Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease ( a total of 3,230 cases and 4,829 controls) and carrie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30fa0ca81d62e96134d54a1b8cfb7e2a
https://ora.ox.ac.uk/objects/uuid:ab25b55e-6edf-4037-b9d3-058c8e785d37

Does co-treatment with immunosuppressors improve outcome in patients with Crohn's disease treated with adalimumab?

Autor: Satish Keshav, Catherine Reenaers, Jacques Belaiche, Simon Travis, Laurence Seidel, Edouard Louis

Summary Background There is clear benefit from combination therapy with infliximab and immunosuppressive drugs (IS), but few data are available for adalimumab (ADA). Aim To assess the efficacy of ADA monotherapy and ADA+IS for induction and maintenan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa1cc9edb2bf5f5d13aea51a9631361
https://ora.ox.ac.uk/objects/uuid:172c69a4-3e35-4986-828c-151f8ea59761

Evolution and predictive factors of relapse in ulcerative colitis patients treated with mesalazine after a first course of corticosteroids

Autor: Catherine Reenaers, Jacques Belaiche, Caroline Bello, Edouard Louis

Publikováno v: Journal of Crohn's and Colitis. 5:196-202

Introduction Mesalazine remains the first line treatment for the induction and the maintenance of remission in mild to moderate ulcerative colitis (UC). Its efficacy as a maintenance treatment after a first flare treated with corticosteroids has not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0f575bee41e7db9c5d02d66cbd01d74
https://doi.org/10.1016/j.crohns.2010.12.011