Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Jacques A Nunès"'
Autor:
Vladimir Laletin, Pierre-Louis Bernard, Camille Montersino, Yuji Yamanashi, Daniel Olive, Rémy Castellano, Geoffrey Guittard, Jacques A. Nunès
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Targeting intracellular inhibiting proteins has been revealed to be a promising strategy to improve CD8+ T cell anti-tumor efficacy. Here, we are focusing on intracellular inhibiting proteins specific to TCR signaling: DOK1 and DOK2 expresse
Externí odkaz:
https://doaj.org/article/e174b2b3812347648dc4451f697c6c33
Autor:
Besma Aouar, Denisa Kovarova, Sebastien Letard, Albert Font-Haro, Jonathan Florentin, Jan Weber, David Durantel, Laurence Chaperot, Joel Plumas, Katerina Trejbalova, Jiri Hejnar, Jacques A Nunès, Daniel Olive, Patrice Dubreuil, Ivan Hirsch, Ruzena Stranska
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156063 (2016)
Crosslinking of regulatory immunoreceptors (RR), such as BDCA-2 (CD303) or ILT7 (CD85g), of plasmacytoid dendritic cells (pDCs) efficiently suppresses production of type-I interferon (IFN)-α/β and other cytokines in response to Toll-like receptor (
Externí odkaz:
https://doaj.org/article/31bcf670f149405b9ee89d6a63e165cf
Autor:
Berna Bou-Tayeh, Vladimir Laletin, Nassim Salem, Sylvaine Just-Landi, Joanna Fares, Raphael Leblanc, Marielle Balzano, Yann M. Kerdiles, Ghislain Bidaut, Olivier Hérault, Daniel Olive, Michel Aurrand-Lions, Thierry Walzer, Jacques A. Nunès, Cyril Fauriat
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Natural Killer (NK) cells are potent anti-leukemic immune effectors. However, they display multiple defects in acute myeloid leukemia (AML) patients leading to reduced anti-tumor potential. Our limited understanding of the mechanisms underlying these
Externí odkaz:
https://doaj.org/article/4769fe68b51142dbbb9fe377ecb4b15a
Autor:
Rebecca B. Delconte, Geoffrey Guittard, Wilford Goh, Soroor Hediyeh-Zadeh, Robert J. Hennessy, Jai Rautela, Melissa J. Davis, Fernando Souza-Fonseca-Guimaraes, Jacques A. Nunès, Nicholas D. Huntington
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Natural killer (NK) cell activation is controlled by a balance of activating and inhibitory signals and cytokines such as IL-15. We previously identified cytokine-inducible SH2-containing protein (CIS) as a negative regulator of IL-15 signaling in NK
Externí odkaz:
https://doaj.org/article/a6b379b2eae14f5581252c091472fc1b
Autor:
Nicla Porciello, Paola Grazioli, Antonio F. Campese, Martina Kunkl, Silvana Caristi, Marta Mastrogiovanni, Michela Muscolini, Francesca Spadaro, Cédric Favre, Jacques A. Nunès, Aldo Borroto, Balbino Alarcon, Isabella Screpanti, Loretta Tuosto
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
CD28 transmits co-stimulatory signals for the activation of both mouse and human T cells, but in vivo hyperactivation of CD28 has opposite effects on system immunity. Here, the authors show that a single amino acid difference between mouse and human
Externí odkaz:
https://doaj.org/article/e98ff31ccbfc47539c572574b4d9cb31
Autor:
Esma Karkeni, Stéphanie O. Morin, Berna Bou Tayeh, Armelle Goubard, Emmanuelle Josselin, Rémy Castellano, Cyril Fauriat, Geoffrey Guittard, Daniel Olive, Jacques A. Nunès
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Women with low levels of vitamin D have a higher risk of developing breast cancer. Numerous studies associated the presence of a CD8+ T cell infiltration with a good prognosis. As vitamin D may play a key role in the modulation of the immune system,
Externí odkaz:
https://doaj.org/article/cd15c40f262c44d5a7df9375f3e9fdac
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
We created APC-mimetic synthetic substrates to study the impact of ligand clustering on T cell activation and spreading. The substrates exhibit antibodies directed against the TCR-complex in the form of a patterned array of sub micrometric dots surro
Externí odkaz:
https://doaj.org/article/44e434638684494785ab07e1a8823048
Autor:
Stéphanie Gon, Marie Loosveld, Thomas Crouzet, Delphine Potier, Mélanie Bonnet, Stéphanie O. Morin, Gérard Michel, Norbert Vey, Jacques A. Nunès, Bernard Malissen, Romain Roncagalli, Bertrand Nadel, Dominique Payet-Bornet
Publikováno v:
Haematologica, Vol 103, Iss 6 (2018)
Signaling through the αβT cell receptor (TCR) is a crucial determinant of T-cell fate and can induce two opposite outcomes during thymocyte development: cell death or survival and differentiation. To date, the role played by T-cell receptor in the
Externí odkaz:
https://doaj.org/article/5f4b2022c7054c69b8bfac278d0e4523
Publikováno v:
Trends in Pharmacological Sciences
Trends in Pharmacological Sciences, 2022, ⟨10.1016/j.tips.2022.08.004⟩
Trends in Pharmacological Sciences, 2022, ⟨10.1016/j.tips.2022.08.004⟩
International audience; The antitumor activity of exercise by means of enhanced immune activation is documented, but better identification of the underlying mechanisms is required to develop new therapeutic strategies. Recent work from the Dr Bar-Sag
Autor:
Amira Ben Amara, Marie-Sarah Rouviere, Stéphane Fattori, Julia Wlosik, Emilie Gregori, Nicolas Boucherit, Pierre-Louis Bernard, Jacques A. Nunès, Norbert Vey, Herve Luche, Laurent Gorvel, Daniel Olive, Anne-Sophie Chretien
Publikováno v:
STAR protocols. 3(4)
This protocol details the step-by-step procedure for in-depth immune phenotyping of peripheral blood natural killer (NK) cells from clinical samples by mass cytometry. The protocol consists of three main steps: PBMC incubation with a mix of metal-con