Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Jacques, Simiand"'
Autor:
Jacques Simiand, Gérard Le Fur, Xavier Emonds-Alt, Liliane Rouquier, J.-C Michaud, Philippe Soubrie, Régis Steinberg, C. Desvignes, M. Jung, Annie Cudennec, Guy Griebel, R. Alonso
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 303:1180-1188
SSR240600 [(R)-2-(1-[2-[4-[2-[3,5-bis(trifluoromethyl)phenyl]acetyl]-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl]-4-piperidinyl)-2-methylpropanamide], a new nonpeptide tachykinin neurokinin 1 (NK1) receptor antagonist, was evaluated against the neuroc
Autor:
J P Maffrand, Jean Wagnon, Claudine Serradeil-Le Gal, Jacques Simiand, Guy Griebel, Bernard Scatton, Marc Pascal, Philippe Soubrie
Publikováno v:
Proceedings of the National Academy of Sciences. 99:6370-6375
The limbic localization of the arginine vasopressin V 1b receptor has prompted speculation as to a potential role of this receptor in the control of emotional processes. To investigate this possibility, we have studied the behavioral effects of SSR14
Autor:
M. Jung, Pierre Roger, Michel Geslin, Jacques Simiand, Jean-Pierre Maffrand, Guy Griebel, Régis Steinberg, Philippe Soubrie, Danielle Gully, Bernard Scatton
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 301:333-345
The present study investigated the effects of the novel corticotrophin-releasing factor (CRF) 1 receptor antagonist 4-(2-chloro-4-methoxy-5-methylphenyl)- N -[(1 S )-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl- N -(2-propynyl)-1,3-thiazol
Autor:
Régis Steinberg, Jean-Pierre Maffrand, Pierre Roger, Georgette Gout, Philippe Soubrie, Evelyne Fontaine, Christine Lair, Danielle Gully, Marc Pascal, Valerie Darre, Michel Geslin, Jacques Simiand, Gérard Le Fur, Rebecca M. Pruss, Pierre-Eric Rouby, Bernard Scatton, Laurence Serva, Josette Guitard, Claudine Marcy, D. Rodier, Guy Griebel
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 301:322-332
4-(2-Chloro-4-methoxy-5-methylphenyl)- N -[(1 S )-2-cyclopropyl-1- (3-fluoro-4-methylphenyl)ethyl]5-methyl- N -(2-propynyl)-1,3-thiazol-2-amine hydrochloride (SSR125543A), a new 2-aminothiazole derivative, shows nanomolar affinity for human cloned or
Autor:
Rebecca M. Pruss, Claude Barberis, Jacques Simiand, Colette Lacour, D. Nisato, Gabrielle Brossard, Philippe Soubrie, Jean Wagnon, Guy Griebel, Claudine Serradeil-Le Gal, Gérard Le Fur, J P Maffrand, Marc Pascal, Bernard Scatton, Gilles Guillon
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 300:1122-1130
(2S,4R)-1-[5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), the first selective, nonpeptide vasopressin V1b receptor antagonist yet describe
Autor:
F. Oury-Donat, Christian Congy, David Shire, Monsif Bouaboula, Jacques Simiand, Philippe Soubrie, Pierre Casellas, Murielle Rinaldi-Carmona, Jean-Claude Breliere, Gérard Le Fur
Publikováno v:
European Journal of Pharmacology: Molecular Pharmacology. 246:73-80
Chronic administration (twice a day for three days and on the morning of the fourth day) of SR 46349B (trans-4-[(3Z)3-(2-dimethylaminoethyl)oxyimino-3-(2-fluoroph enyl)propen-1- yl]phenol hemifumarate) (10 mg/kg, orally), a selective 5-HT2 receptor a
Autor:
Patrice Venault, Marie-Josee Raffalli-Sebille, Georges Chapouthier, Jacques Simiand, Robert H. Dodd
Publikováno v:
Psychobiology. 19:58-63
Benzodiazepines are known to induce profound amnesia in man. In this report, we show, in mice, that whereas benzodiazepine diazepam indeed impairs performance, methyl beta-carboline-3-carboxylate gB-CCM), an inverse agonist of the benzodiazepine rece
Autor:
Rolf C. Gaillard, Gilles Guillon, Guy Griebel, Maurice Manning, Jacques Simiand, Sylvain Derick, Gabrielle Brossard, Claudine Serradeil-Le Gal
Publikováno v:
Stress (Amsterdam, Netherlands). 6(3)
By activating three distinct vasopressin receptor isoforms called V1a-R, V1b-R (V3-R) and V2-R, vasopressin (VP) mediates a wide number of biological effects in mammals and may be involved in several pathological states. Up to now only specific V1a a
Autor:
Bernard Scatton, Michel Decobert, Ronan Depoortère, Philippe Soubrie, Jacques Simiand, Denis Boulay, Olivier Bergis, Dominique Françon, M. Jung, Ghislaine Perrault
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 28(11)
SSR181507 ((3-exo)-8-benzoyl-N-(((2S)7-chloro-2,3-dihydro-1,4-benzodioxin-1-yl)methyl)-8-azabicyclo(3.2.1)octane-3-methanamine monohydrochloride) is a novel tropanemethanamine benzodioxane that displays antagonist activity at dopamine D(2) receptors
Autor:
Patrick Avenet, Jacques Simiand, Yannick Evanno, Mireille Sevrin, Caroline Cohen, Pascal George, Patrick Granger, Henri Depoortere, Guy Griebel, Ghislaine Perrault, Dominique Françon, Hans Schoemaker, Bernard Scatton
Publikováno v:
CNS drug reviews. 9(1)
SL651498 (6-fluoro-9-methyl-2-phenyl-4-(pyrrolidin-1-yl-carbonyl)-2,9-dihydro-1H-pyrido[3,4-b]indol-1-one) was identified as a drug development candidate from a research program designed to discover subtype-selective GABA(A) receptor agonists for the