Výsledky vyhledávání - "Jacques, Grober"

Akademický článek

Increased Phospholipid Transfer Protein Activity Is Associated With Markers of Enhanced Lipopolysaccharide Clearance in Human During Cardiopulmonary Bypass

Autor: Maxime Nguyen, Thomas Gautier, Guillaume Reocreux, Gaëtan Pallot, Guillaume Maquart, Pierre-Alain Bahr, Annabelle Tavernier, Jacques Grober, David Masson, Belaid Bouhemad, Pierre-Grégoire Guinot

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 8 (2021)

Introduction: Lipopolysaccharide (LPS) is a component of gram-negative bacteria, known for its ability to trigger inflammation. The main pathway of LPS clearance is the reverse lipopolysaccharide transport (RLT), with phospholipid transfer protein (P

Externí odkaz: https://doaj.org/article/8853f1b0e5eb49409b7d1efd34a823d0

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Akademický článek

Human cholesteryl ester transfer protein lacks lipopolysaccharide transfer activity, but worsens inflammation and sepsis outcomes in mice

Autor: Aloïs Dusuel, Valérie Deckert, Jean-Paul Pais de Barros, Kevin van Dongen, Hélène Choubley, Émilie Charron, Naig Le Guern, Jérôme Labbé, Stéphane Mandard, Jacques Grober, Laurent Lagrost, Thomas Gautier

Publikováno v: Journal of Lipid Research, Vol 62, Iss , Pp 100011- (2021)

Bacterial lipopolysaccharides (LPSs or endotoxins) can bind most proteins of the lipid transfer/LPS-binding protein (LT/LBP) family in host organisms. The LPS-bound LT/LBP proteins then trigger either an LPS-induced proinflammatory cascade or LPS bin

Externí odkaz: https://doaj.org/article/44bb1260f336492c90708a2cd50fdd02

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Akademický článek

Deletion of lysophosphatidylcholine acyltransferase 3 in myeloid cells worsens hepatic steatosis after a high-fat diet

Publikováno v: Journal of Lipid Research, Vol 62, Iss , Pp 100013- (2021)

Recent studies have highlighted an important role for lysophosphatidylcholine acyltransferase 3 (LPCAT3) in controlling the PUFA composition of cell membranes in the liver and intestine. In these organs, LPCAT3 critically supports cell-membrane-assoc

Externí odkaz: https://doaj.org/article/83c4b2a37855418097b19c9a61a1428a

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Akademický článek

Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion

Autor: Lorène J. Lebrun, Kaatje Lenaerts, Dorien Kiers, Jean-Paul Pais de Barros, Naig Le Guern, Jiri Plesnik, Charles Thomas, Thibaut Bourgeois, Cornelis H.C. Dejong, Matthijs Kox, Inca H.R. Hundscheid, Naim Akhtar Khan, Stéphane Mandard, Valérie Deckert, Peter Pickkers, Daniel J. Drucker, Laurent Lagrost, Jacques Grober

Publikováno v: Cell Reports, Vol 21, Iss 5, Pp 1160-1168 (2017)

Summary: Glucagon-like peptide 1 (GLP-1) is a hormone released from enteroendocrine L cells. Although first described as a glucoregulatory incretin hormone, GLP-1 also suppresses inflammation and promotes mucosal integrity. Here, we demonstrate that

Externí odkaz: https://doaj.org/article/54c442ddf2554e8d93b3af382d5f41cd

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Akademický článek

Recombinant human plasma phospholipid transfer protein (PLTP) to prevent bacterial growth and to treat sepsis

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)

Abstract Although plasma phospholipid transfer protein (PLTP) has been mainly studied in the context of atherosclerosis, it shares homology with proteins involved in innate immunity. Here, we produced active recombinant human PLTP (rhPLTP) in the mil

Externí odkaz: https://doaj.org/article/38bc086aee0d4b64bfb9adb2801c05a8

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Evidence for Constitutive Microbiota-Dependent Short-Term Control of Food Intake in Mice: Is There a Link with Inflammation, Oxidative Stress, Endotoxemia, and GLP-1?

Publikováno v: Antioxidants and Redox Signaling
Antioxidants and Redox Signaling, 2022, 37 (4-6), pp.349-369. ⟨10.1089/ars.2021.0095⟩

International audience; AIMS: Although prebiotics, probiotics, and fecal transplantation can alter the sensation of hunger and/or feeding behavior, the role of the constitutive gut microbiota in the short-term regulation of food intake during normal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858f4a298e1bf0e846e2bdb61536f668
https://doi.org/10.1089/ars.2021.0095

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Akademický článek

Immune Cell Toll-like Receptor 4 Mediates the Development of Obesity- and Endotoxemia-Associated Adipose Tissue Fibrosis

Autor: Isabelle K. Vila, Pierre-Marie Badin, Marie-Adeline Marques, Laurent Monbrun, Corinne Lefort, Lucile Mir, Katie Louche, Virginie Bourlier, Balbine Roussel, Philippe Gui, Jacques Grober, Vladimír Štich, Lenka Rossmeislová, Alexia Zakaroff-Girard, Anne Bouloumié, Nathalie Viguerie, Cedric Moro, Geneviève Tavernier, Dominique Langin

Publikováno v: Cell Reports, Vol 7, Iss 4, Pp 1116-1129 (2014)

Adipose tissue fibrosis development blocks adipocyte hypertrophy and favors ectopic lipid accumulation. Here, we show that adipose tissue fibrosis is associated with obesity and insulin resistance in humans and mice. Kinetic studies in C3H mice fed a

Externí odkaz: https://doaj.org/article/9e538370a29c4ef6a42f016c190cdfe4

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Akademický článek

Farnesoid X receptor activation increases cholesteryl ester transfer protein expression in humans and transgenic mice

Autor: Thomas Gautier, Willeke de Haan, Jacques Grober, Dan Ye, Matthias J. Bahr, Thierry Claudel, Niels Nijstad, Theo J.C. Van Berkel, Louis M. Havekes, Michael P. Manns, Stefan M. Willems, Pancras C.W. Hogendoorn, Laurent Lagrost, Folkert Kuipers, Miranda Van Eck, Patrick C.N. Rensen, Uwe J.F. Tietge

Publikováno v: Journal of Lipid Research, Vol 54, Iss 8, Pp 2195-2205 (2013)

Cholesteryl ester transfer protein (CETP) activity results in a proatherogenic lipoprotein profile. In cholestatic conditions, farnesoid X receptor (FXR) signaling by bile acids (BA) is activated and plasma HDL cholesterol (HDL-C) levels are low. Thi

Externí odkaz: https://doaj.org/article/70b732072eac42ef9a7951d48e70bab0

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Activation of TLRs Triggers GLP-1 Secretion in Mice

Autor: Lorène J. Lebrun, Alois Dusuel, Marion Xolin, Naig Le Guern, Jacques Grober

Publikováno v: International Journal of Molecular Sciences. 24:5333

The gastrointestinal tract constitutes a large interface with the inner body and is a crucial barrier against gut microbiota and other pathogens. As soon as this barrier is damaged, pathogen-associated molecular patterns (PAMPs) are recognized by imm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7794d9ad854827d87d6a38eac2664f7
https://doi.org/10.3390/ijms24065333

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