Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jacquelyn Lyons"'
Autor:
Thao Ung, Ronald Robinson, Chrysanthe Spais, Justin Schreiber, Hussein Hallak, Jean Husten, Thelma S. Angeles, Jacquelyn Lyons, Yun Liu
Publikováno v:
Bioanalysis. 13:575-585
Aim: To quantify the free form of a protein as a target-engagement biomarker in nonhuman primate serum, a Meso Scale Discovery ligand-binding assay was developed and qualified. Results: The initial assay produced an unexpected artifact when used to m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ce1411ff5e30f589db719afc908cd8
https://doi.org/10.4155/bio-2020-0307
https://doi.org/10.4155/bio-2020-0307
Autor:
Danyal Butt, Jacquelyn Lyons, Matthew Pollard, Anthony Gerard Doyle, Chen Tian, Doris Shim, Jean Husten, David Mabon, Lynn Dorothy Poulton, Adam Clarke, Vanya Pande
Publikováno v:
mAbs
TL1A is an attractive therapeutic target for the treatment of mucosal inflammation associated with inflammatory bowel disease (IBD) and asthma. Blockade of the TL1A pathway has been shown to reduce inflammatory responses while leaving baseline immuni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::654c0360ea2a1513a8b707f3d470befb
https://doi.org/10.1080/19420862.2018.1440164
https://doi.org/10.1080/19420862.2018.1440164
Autor:
Mark, Liddament, Jean, Husten, Tanya, Estephan, David, Laine, David, Mabon, Laurie, Pukac, Jacquelyn, Lyons, Adam W, Clarke, Anthony, Doyle
Publikováno v:
Allergy, Asthma & Immunology Research
Reslizumab and mepolizumab are recently approved monoclonal antibodies for the treatment of severe (uncontrolled) eosinophilic asthma. Both are effective in neutralizing the function of interleukin-5 (IL-5). This study is the first to compare the bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e844824c9033a5dc7d7f33c9925d4657
https://pubmed.ncbi.nlm.nih.gov/30661320
https://pubmed.ncbi.nlm.nih.gov/30661320
Autor:
Laurie Pukac, Anthony Gerard Doyle, Jacquelyn Lyons, Jean Husten, David Mabon, Adam Clarke, Mark T. Liddament, Tanya Estephan, David Jose Simon Laine
Publikováno v:
Allergy, Asthma & Immunology Research. 11:291
Reslizumab and mepolizumab are recently approved monoclonal antibodies for the treatment of severe (uncontrolled) eosinophilic asthma. Both are effective in neutralizing the function of interleukin-5 (IL-5). This study is the first to compare the bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb6a44f168394b55c103983a312f94f2
https://doi.org/10.4168/aair.2019.11.2.291
https://doi.org/10.4168/aair.2019.11.2.291
Autor:
Ming, Tao, Lisa D, Aimone, Zeqi, Huang, Joanne, Mathiasen, Rita, Raddatz, Jacquelyn, Lyons, Robert L, Hudkins
Publikováno v:
Journal of medicinal chemistry. 55(1)
Previous studies have shown that (5-{4-[3-(R)-2-methylpyrrolin-1-yl-propoxy]phenyl}-2H-pyridazin-3-one) 2 had high affinity for both the human (hH(3)R K(i) = 2.8 nM) and rat H(3)Rs (rH(3)R K(i) = 8.5 nM) but displayed low oral bioavailability in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c5e9a91d12df785b118140656369f3d4
https://pubmed.ncbi.nlm.nih.gov/22107017
https://pubmed.ncbi.nlm.nih.gov/22107017
Autor:
Robert L, Hudkins, Lisa D, Aimone, Thomas R, Bailey, Robert J, Bendesky, Reddeppa Reddy, Dandu, Derek, Dunn, John A, Gruner, Kurt A, Josef, Yin-Guo, Lin, Jacquelyn, Lyons, Val R, Marcy, Joanne R, Mathiasen, Babu G, Sundar, Ming, Tao, Allison L, Zulli, Rita, Raddatz, Edward R, Bacon
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(18)
H(3)R structure-activity relationships on a novel class of pyridazin-3-one H(3)R antagonists/inverse agonists are disclosed. Modifications of the pyridazinone core, central phenyl ring and linker led to the identification of molecules with excellent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::751b027788338fa7af0c76f12a30b863
https://pubmed.ncbi.nlm.nih.gov/21782432
https://pubmed.ncbi.nlm.nih.gov/21782432
Autor:
Babu G, Sundar, Thomas, Bailey, Edward, Bacon, Lisa, Aimone, Zeqi, Huang, Jacquelyn, Lyons, Rita, Raddatz, Robert, Hudkins
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(18)
Pyridazinone 1 was recently reported as a potent H(3)R antagonist with good drug-like properties and in vivo activity. A series of constrained amine analogs of 1 was synthesized to identify compounds with improved pharmacokinetic profiles. From these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a8196628b9170a7a7ccee21d28ca165b
https://pubmed.ncbi.nlm.nih.gov/21824776
https://pubmed.ncbi.nlm.nih.gov/21824776
Autor:
Ming Tao, Lisa D. Aimone, Zeqi Huang, Joanne Mathiasen, Rita Raddatz, Jacquelyn Lyons, Robert L. Hudkins
Publikováno v:
Journal of Medicinal Chemistry; Jan2012, Vol. 55 Issue 1, p414-423, 10p