Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Jacquelyn Bond"'
Autor:
Heather L. Martin, Amy L. Turner, Julie Higgins, Anna A. Tang, Christian Tiede, Thomas Taylor, Sitthinon Siripanthong, Thomas L. Adams, Iain W. Manfield, Sandra M. Bell, Ewan E. Morrison, Jacquelyn Bond, Chi H. Trinh, Carolyn D. Hurst, Margaret A. Knowles, Richard W. Bayliss, Darren C. Tomlinson
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113184- (2023)
Summary: Kinases are important therapeutic targets, and their inhibitors are classified according to their mechanism of action, which range from blocking ATP binding to covalent inhibition. Here, a mechanism of inhibition is highlighted by capturing
Externí odkaz:
https://doaj.org/article/602d6e2e2cea4be1917c7c7c7b34ebd6
Autor:
Andrew J. Smith, Prashant Ruchaya, Robert Walmsley, Kathleen E. Wright, Fiona C. Lewis-McDougall, Jacquelyn Bond, Georgina M. Ellison-Hughes
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Receptor tyrosine kinase inhibitors improve cancer survival but their cardiotoxicity requires investigation. We investigated these inhibitors’ effects on human cardiac progenitor cells in vitro and rat heart in vivo. We applied imatinib, s
Externí odkaz:
https://doaj.org/article/6ba39ab0a0914d2691c22b3b6ff3747b
Autor:
Heather L Martin, Matthew Adams, Julie Higgins, Jacquelyn Bond, Ewan E Morrison, Sandra M Bell, Stuart Warriner, Adam Nelson, Darren C Tomlinson
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88338 (2014)
Toxicity is a major cause of failure in drug discovery and development, and whilst robust toxicological testing occurs, efficiency could be improved if compounds with cytotoxic characteristics were identified during primary compound screening. The us
Externí odkaz:
https://doaj.org/article/662c944ba0d54a6e9808ab389a227357
Autor:
Rawiah Alsiary, Anke Brüning-Richardson, Jacquelyn Bond, Ewan E Morrison, Nafisa Wilkinson, Sandra M Bell
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97059 (2014)
Mutations in the MCPH1 (Microcephalin) and ASPM (abnormal spindle-like microcephaly associated) genes cause primary microcephaly. Both are centrosomal associated proteins involved in mitosis. Microcephalin plays an important role in DNA damage respon
Externí odkaz:
https://doaj.org/article/6b650dabf57e4ffb9d1f9912c5bb0c0d
Autor:
Heather Louise Martin, Amy L. Turner, Julie Higgins, Anna A. Tang, Christian Tiede, Thomas Taylor, Thomas L. Adams, Sandra M. Bell, Ewan E. Morrison, Jacquelyn Bond, Chi H. Trinh, Carolyn D. Hurst, Margaret Knowles, Richard Bayliss, Darren C. Tomlinson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8917ff9c581be0aeeeaa231bf174caa
https://doi.org/10.2139/ssrn.4350139
https://doi.org/10.2139/ssrn.4350139
Autor:
Henry King, Alastair Droop, Ewan E. Morrison, Ruth Morton, Susan C Short, Julie Higgins, Gary Shaw, Peter Laslo, B. da Silva, Euan S. Polson, Lynette Steele, Daniel Tams, Heather L. Martin, Matthew Adams, Heiko Wurdak, Darren C. Tomlinson, Sean E. Lawler, Marjorie Boissinot, Josie Hayes, Jacquelyn Bond, Thomas Ward
Publikováno v:
Oncogene
MicroRNAs play an important role in the regulation of mRNA translation and have therapeutic potential in cancer and other diseases. To profile the landscape of microRNAs with significant cytotoxicity in the context of glioblastoma (GBM), we performed
Autor:
Andrew J, Smith, Prashant, Ruchaya, Robert, Walmsley, Kathleen E, Wright, Fiona C, Lewis-McDougall, Jacquelyn, Bond, Georgina M, Ellison-Hughes
Publikováno v:
Scientific reports. 12(1)
Receptor tyrosine kinase inhibitors improve cancer survival but their cardiotoxicity requires investigation. We investigated these inhibitors' effects on human cardiac progenitor cells in vitro and rat heart in vivo. We applied imatinib, sunitinib or
Autor:
Elizabeth A. Roundhill, Lee Jeys, Michael Parry, Kenneth S. Rankin, Richard Foster, Jacquelyn Bond, Susan Burchill
Publikováno v:
Cancer Research. 82:1847-1847
Since Ewing sarcoma (ES) is a stem cell-like cancer1, improved outcome for some patients will be realised when treatments to eradicate ES stem-like cells (ES-CSCs) are evaluated in clinical trials. Therefore, we have identified small molecules that k
Autor:
Basudha Basu, Sushma Nagaraja Grellscheid, Subaashini Natarajan, Colin A. Johnson, Rachel Trowbridge, Sunayna Best, Richard Foster, Claire E. L. Smith, Alice V.R. Lake, Jacquelyn Bond, Thomas Stevenson
Primary cilia are microtubule-based organelles that act as cellular antennae to mediate vertebrate development and growth factor signalling. Defects in primary cilia result in a group of inherited developmental conditions known as ciliopathies. Cilio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53edd59740aaf855afe893762b638608
https://doi.org/10.1101/2020.11.26.393801
https://doi.org/10.1101/2020.11.26.393801
Autor:
Susan A. Burchill, Rawiah A. Alsiary, Nicholas Griffin, Anke Brüning-Richardson, Sandra M. Bell, Jacquelyn Bond, Richard Hutson, Ewan E. Morrison, Samantha C. Brownhill
Publikováno v:
Gene. 672:34-44
Aims The aim of this study was to explore the correlation of hTERT splice variant expression with MCPH1/BRIT1 and BRCA1 expression in epithelial ovarian cancer (EOC) samples. Background Telomerase activation can contribute to the progression of tumor