Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Jacquelyn A. Brown"'
Autor:
Mengying Xia, Mahboubeh Varmazyad, Iris Pla-Palacín, Dillon C. Gavlock, Richard DeBiasio, Gregory LaRocca, Celeste Reese, Rodrigo M. Florentino, Lanuza A. P. Faccioli, Jacquelyn A. Brown, Lawrence A. Vernetti, Mark Schurdak, Andrew M. Stern, Albert Gough, Jaideep Behari, Alejandro Soto-Gutierrez, D. Lansing Taylor, Mark T. Miedel
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a worldwide health epidemic with a global occurrence of approximately 30%. The pathogenesis of MASLD is a complex, multisystem disorder driven by multiple factors, including genetics
Externí odkaz:
https://doaj.org/article/ee7744aae33d4960a923808275c298d0
Autor:
Jacquelyn A. Brown, Shannon L. Faley, Monika Judge, Patricia Ward, Rebecca A. Ihrie, Robert Carson, Laura Armstrong, Mustafa Sahin, John P. Wikswo, Kevin C. Ess, M. Diana Neely
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 16, Iss 1, Pp 1-16 (2024)
Abstract Background Tuberous sclerosis complex (TSC) is a multi-system genetic disease that causes benign tumors in the brain and other vital organs. The most debilitating symptoms result from involvement of the central nervous system and lead to a m
Externí odkaz:
https://doaj.org/article/302796375aee43128c1c645409209e15
Autor:
Sirle Saul, Marwah Karim, Luca Ghita, Pei-Tzu Huang, Winston Chiu, Verónica Durán, Chieh-Wen Lo, Sathish Kumar, Nishank Bhalla, Pieter Leyssen, Farhang Alem, Niloufar A. Boghdeh, Do H.N. Tran, Courtney A. Cohen, Jacquelyn A. Brown, Kathleen E. Huie, Courtney Tindle, Mamdouh Sibai, Chengjin Ye, Ahmed Magdy Khalil, Kevin Chiem, Luis Martinez-Sobrido, John M. Dye, Benjamin A. Pinsky, Pradipta Ghosh, Soumita Das, David E. Solow-Cordero, Jing Jin, John P. Wikswo, Dirk Jochmans, Johan Neyts, Steven De Jonghe, Aarthi Narayanan, Shirit Einav
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
Targeting host factors exploited by multiple viruses could offer broad-spectrum solutions for pandemic preparedness. Seventeen candidates targeting diverse functions emerged in a screen of 4,413 compounds for SARS-CoV-2 inhibitors. We demonstrated th
Externí odkaz:
https://doaj.org/article/9cc9d935abdc4025aa6c81ab75a6d932
Autor:
Jacquelyn A. Brown, Shannon L. Faley, Yajuan Shi, Kathleen M. Hillgren, Geri A. Sawada, Thomas K. Baker, John P. Wikswo, Ethan S. Lippmann
Publikováno v:
Fluids and Barriers of the CNS, Vol 17, Iss 1, Pp 1-12 (2020)
Abstract Background The United States faces a national crisis involving opioid medications, where currently more than 130 people die every day. To combat this epidemic, a better understanding is needed of how opioids penetrate into the central nervou
Externí odkaz:
https://doaj.org/article/49808a32bc8148a188637c57a5c58771
Autor:
Niloufar A. Boghdeh, Kenneth H. Risner, Michael D. Barrera, Clayton M. Britt, David K. Schaffer, Farhang Alem, Jacquelyn A. Brown, John P. Wikswo, Aarthi Narayanan
Publikováno v:
Viruses, Vol 14, Iss 12, p 2799 (2022)
The blood brain barrier (BBB) is a multicellular microenvironment that plays an important role in regulating bidirectional transport to and from the central nervous system (CNS). Infections by many acutely infectious viruses such as alphaviruses and
Externí odkaz:
https://doaj.org/article/fe4563b4c86244a9a3719032e2a49db1
Autor:
Jacquelyn A. Brown, Szatmár Horváth, Krassimira A. Garbett, Martin J. Schmidt, Monika Everheart, Levente Gellért, Philip Ebert, Károly Mirnics
Publikováno v:
Neurobiology of Disease, Vol 63, Iss , Pp 210-221 (2014)
Schizophrenia is a devastating neurodevelopmental disorder that affects approximately 1% of the population. Reduced expression of the 67-kDa protein isoform of glutamic acid decarboxylase (GAD67) is a hallmark of the disease and is encoded by the GAD
Externí odkaz:
https://doaj.org/article/7abcb84a6de745aabc272aa9c75dde27
Autor:
Thomas K. Baker, John P. Wikswo, Geri A. Sawada, Shannon Faley, Kathleen M. Hillgren, Ethan S. Lippmann, Yajuan Shi, Jacquelyn A. Brown
Publikováno v:
Fluids and Barriers of the CNS, Vol 17, Iss 1, Pp 1-12 (2020)
Fluids and Barriers of the CNS
Fluids and Barriers of the CNS
Background The United States faces a national crisis involving opioid medications, where currently more than 130 people die every day. To combat this epidemic, a better understanding is needed of how opioids penetrate into the central nervous system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e40547f31670d968e99447a64cade29a
http://link.springer.com/article/10.1186/s12987-020-00200-9
http://link.springer.com/article/10.1186/s12987-020-00200-9
Publikováno v:
Clinical Pharmacology and Therapeutics
The complexity of integrating microbiota into clinical pharmacology, environmental toxicology, and opioid studies arises from bidirectional and multiscale interactions between humans and their many microbiota, notably those of the gut. Hosts and each
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711d5476a8468d3d3be4b51e969e9045
https://doi.org/10.1002/cpt.1870
https://doi.org/10.1002/cpt.1870
Autor:
Michelle D Cully, Yinling Hu, Michael P. Cancro, Nipun Jayachandran, Ellen Puré, Michael J. May, Bruce D. Freedman, Jorge I. Alvarez, James Monslow, Jacquelyn Freund-Brown, Kelly A. McCorkell, Tiffany Weinkopff
Publikováno v:
Proc Natl Acad Sci U S A
Global inactivation of IκB kinase (IKK)-α results in defective lymph node (LN) formation and B cell maturation, and loss of IKK-α–dependent noncanonical NF-κB signaling in stromal organizer and hematopoietic cells is thought to underlie these d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e0273640f68b217d3db0ba0668cb0c
https://pubmed.ncbi.nlm.nih.gov/34810256
https://pubmed.ncbi.nlm.nih.gov/34810256
Autor:
Sirle Saul, Marwah Karim, Luca Ghita, Pei-Tzu Huang, Winston Chiu, Verónica Durán, Chieh-Wen Lo, Sathish Kumar, Nishank Bhalla, Pieter Leyssen, Farhang Alem, Niloufar A. Boghdeh, Do HN Tran, Courtney A. Cohen, Jacquelyn A. Brown, Kathleen E. Huie, Courtney Tindle, Mamdouh Sibai, Chengjin Ye, Ahmed Magdy Khalil, Luis Martinez-Sobrido, John M. Dye, Benjamin A. Pinsky, Pradipta Ghosh, Soumita Das, David E. Solow-Cordero, Jing Jin, John P. Wikswo, Dirk Jochmans, Johan Neyts, Steven De Jonghe, Aarthi Narayanan, Shirit Einav
Targeting host factors exploited by multiple viruses could offer broad-spectrum solutions for pandemic preparedness. Seventeen candidates targeting diverse functions emerged in a screen of 4,413 compounds for SARS-CoV-2 inhibitors. We demonstrated th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcd80e2a2ac97bdced0f99fed6e8c8f8
https://doi.org/10.1101/2021.05.15.444128
https://doi.org/10.1101/2021.05.15.444128
