Výsledky vyhledávání - "Jacqueline Wubben"

Akademický článek

Severe oxidative stress in an acute inflammatory demyelinating model in the rhesus monkey.

Autor: Jordon Dunham, Reinofke van de Vis, Jan Bauer, Jacqueline Wubben, Nikki van Driel, Jon D Laman, Bert A 't Hart, Yolanda S Kap

Publikováno v: PLoS ONE, Vol 12, Iss 11, p e0188013 (2017)

Oxidative stress is increasingly implicated as a co-factor of tissue injury in inflammatory/demyelinating disorders of the central nervous system (CNS), such as multiple sclerosis (MS). While rodent experimental autoimmune encephalomyelitis (EAE) mod

Externí odkaz: https://doaj.org/article/e926f39c6e2344469c3f3b2c7341d607

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SARS-CoV-2 causes brain inflammation and induces Lewy body formation in macaques

Autor: Eva Roos, Babs E. Verstrepen, Ernst J. Verschoor, Marianna Bugiani, Lioe-Fee de Geus-Oei, Jan A.M. Langermans, Jacqueline Wubben, Ronald E. Bontrop, Willy M. J. M. Bogers, Diana Lozovagia, Zahra Fagrouch, Bernadette Schurink, Amber Q. Mayenburg, Nikki van Driel, Marieke A. Stammes, Ingrid H.C.H.M. Philippens, Jinte Middeldorp, Kinga P. Böszörményi

SARS-CoV-2 may cause acute respiratory disease, but the infection can also initiate neurological symptoms. Here we show that SARS-CoV-2 infection causes brain inflammation in the macaque model. An increased metabolic activity in the pituitary gland o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a26d4958b42abf56a35b0790ad5ab6f
https://doi.org/10.1101/2021.02.23.432474

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Involvement of the Red Nucleus in the Compensation of Parkinsonism may Explain why Primates can develop Stable Parkinson’s Disease

Autor: Jan A.M. Langermans, Sam O. Hofman, Ingrid H.C.H.M. Philippens, Sigrid K. Franke, Jacqueline Wubben

Publikováno v: Scientific Reports, 9:880, 1-9. Nature Publishing Group
Scientific Reports
Scientific Reports, 9(1). NLM (Medline)
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Philippens, I H C H M, Wubben, J A, Franke, S K, Hofman, S & Langermans, J A M 2019, ' Involvement of the Red Nucleus in the Compensation of Parkinsonism may Explain why Primates can develop Stable Parkinson’s Disease ', Scientific Reports, vol. 9, 880, pp. 1-9 . https://doi.org/10.1038/s41598-018-37381-1

Neurological compensatory mechanisms help our brain to adjust to neurodegeneration as in Parkinson’s disease. It is suggested that the compensation of the damaged striato-thalamo-cortical circuit is focused on the intact thalamo-rubro-cerebellar pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae090b2248635460ea4d302005f1399c
https://research.vu.nl/en/publications/1ece4d82-5f1b-4609-8fd6-35bfdddf40f8

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Individual and Familial Susceptibility to MPTP in a Common Marmoset Model for Parkinson's Disease

Autor: August B. Smit, Sam O. Hofman, Ronald E. van Kesteren, Sigrid K. Franke, Jacqueline Wubben, Ingrid H.C.H.M. Philippens

Publikováno v: van Kesteren, R E, Hofman, S, Wubben, J A M, Smit, A B & Philippens, I H C H M 2016, ' Individual and Familial Susceptibility to MPTP in a Common Marmoset Model for Parkinson's Disease ', Neurodegenerative Diseases, vol. 16, no. 5-6, pp. 293-303 . https://doi.org/10.1159/000442574
Neurodegenerative Diseases, 16(5-6), 293-303. S. Karger AG

Introduction: Insight into susceptibility mechanisms underlying Parkinson's disease (PD) would aid the understanding of disease etiology, enable target finding and benefit the development of more refined disease-modifying strategies. Methods: We used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1cf0e693d00d416092a73f222888f1
https://doi.org/10.1159/000442574

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Progression and recovery of Parkinsonism in a chronic progressive MPTP-induction model in the marmoset without persistent molecular and cellular damage

Autor: Jacqueline Wubben, August B. Smit, R.E. van Kesteren, Sam O. Hofman, Iryna Paliukhovich, R.C. van der Schors, P. van Nierop, S.K. Franke, Ingrid H.C.H.M. Philippens

Publikováno v: Neuroscience, 312, 247-259. Elsevier Limited
Franke, S K, van Kesteren, R E, Wubben, J A, Hofman, S, Paliukhovich, I, van der Schors, R C, van Nierop, P, Smit, A B & Philippens, I H C H M 2016, ' Progression and recovery of Parkinsonism in a chronic progressive MPTP-induction model in the marmoset without persistent molecular and cellular damage ', Neuroscience, vol. 312, pp. 247-259 . https://doi.org/10.1016/j.neuroscience.2015.09.065

Chronic exposure to low-dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in marmoset monkeys was used to model the prodromal stage of Parkinson's disease (PD), and to investigate mechanisms underlying disease progression and recovery. Marmose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac8051a49ae329c83c47190f4bf61950
https://doi.org/10.1016/j.neuroscience.2015.09.065

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Lymphoid-Like Structures with Distinct B Cell Areas in Kidney Allografts are not Predictive for Graft Rejection. A Non-human Primate Study

Autor: Margreet Jonker, Krista G. Haanstra, Jacqueline Wubben, Bert A. 't Hart

Publikováno v: Inflammation, 38(6), 2191-2202

Kidney allograft biopsies were analyzed for the presence of B cell clusters/aggregates using CD20 staining. Few B cells were found in the diffuse interstitial infiltrates, but clusters of B cells were found in nodular infiltrates. These nodular infil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c21b43cd1ff66ed6406a5a4b294d6b
https://research.rug.nl/en/publications/b5daa1e4-147a-4c2b-bdfe-f96ea674a24c

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Severe oxidative stress in an acute inflammatory demyelinating model in the rhesus monkey

Autor: Reinofke van de Vis, Jordon Dunham, Jan Bauer, Bert A. 't Hart, Yolanda S. Kap, Jacqueline Wubben, Nikki van Driel, Jon D. Laman

Publikováno v: PLoS ONE
PLoS ONE, 12(11):e0188013. PUBLIC LIBRARY SCIENCE
PLoS ONE, Vol 12, Iss 11, p e0188013 (2017)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::705f7c019730ca59ac27b7b4c9dec0c8
http://europepmc.org/articles/PMC5685592

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Oral Treatment with the NADPH Oxidase Antagonist Apocynin Mitigates Clinical and Pathological Features of Parkinsonism in the MPTP marmoset Model

Autor: Bert A. 't Hart, Jacqueline Wubben, Ingrid H. C. H. M. Philippens, Bente Finsen

Publikováno v: Philippens, I H C H M, Wubben, J A, Finsen, B & 't Hart, B A 2013, ' Oral treatment with the NADPH oxidase antagonist apocynin mitigates clinical and pathological features of parkinsonism in the MPTP marmoset model ', Journal of Neuroimmune Pharmacology, vol. 8, no. 3, pp. 715-726 . https://doi.org/10.1007/s11481-013-9450-z
Journal of neuroimmune pharmacology, 8(3), 715-726. SPRINGER

This study evaluates the therapeutic efficacy of the NADPH oxidase inhibitor apocynin, isolated as principal bioactive component from the medicinal plant Picrorhiza kurroa, in a marmoset MPTP model of Parkinson's disease (PD). The methoxy-substituted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d07976d5de32ad802c6d76dfc76b7634
https://hdl.handle.net/11370/fd41a0d1-081e-4c1b-baa7-074579d4b562

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