Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Jacqueline Unsinger"'
Autor:
Sun Ryu, Jintao Zhang, Roli Simoes, Xuemei Liu, Zhaohua Guo, Li Feng, Jacqueline Unsinger, Richard S. Hotchkiss, Yu-Qing Cao
Publikováno v:
The Journal of Headache and Pain, Vol 25, Iss 1, Pp 1-19 (2024)
Abstract Background Medication overuse headache (MOH) is the most common secondary headache disorder, resulting from chronic and excessive use of medication to treat headaches, for example, sumatriptan. In a recent study, we have shown that the perip
Externí odkaz:
https://doaj.org/article/0afc7094512b452f9250ba1226d66939
Autor:
Thomas Daix, Armelle Mathonnet, Scott Brakenridge, Pierre-François Dequin, Jean-Paul Mira, Frederique Berbille, Michel Morre, Robin Jeannet, Teresa Blood, Jacqueline Unsinger, Jane Blood, Andrew Walton, Lyle L. Moldawer, Richard Hotchkiss, Bruno François
Publikováno v:
Annals of Intensive Care, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Background Profound lymphopenia is an independent predictor of adverse clinical outcomes in sepsis. Interleukin-7 (IL-7) is essential for lymphocyte proliferation and survival. A previous phase II study showed that CYT107, a glycosylated rec
Externí odkaz:
https://doaj.org/article/ac01ea5bbb564dde939f73024683bed3
Publikováno v:
Neurobiology of Pain, Vol 12, Iss , Pp 100096- (2022)
Low-dose interleukin-2 (LD-IL-2) treatment has been shown to effectively reverse chronic migraine-related behaviors and the sensitization of trigeminal ganglion (TG) neurons through expansion and activation of peripheral regulatory T cells (Tregs) in
Externí odkaz:
https://doaj.org/article/394e24f1d66e4d9ebfb5d5b3c25549bc
Autor:
Kenneth E. Remy, Monty Mazer, David A. Striker, Ali H. Ellebedy, Andrew H. Walton, Jacqueline Unsinger, Teresa M. Blood, Philip A. Mudd, Daehan J. Yi, Daniel A. Mannion, Dale F. Osborne, R. Scott Martin, Nitin J. Anand, James P. Bosanquet, Jane Blood, Anne M. Drewry, Charles C. Caldwell, Isaiah R. Turnbull, Scott C. Brakenridge, Lyle L. Moldwawer, Richard S. Hotchkiss
Publikováno v:
JCI Insight, Vol 5, Iss 17 (2021)
COVID-19–associated morbidity and mortality have been attributed to a pathologic host response. Two divergent hypotheses have been proposed: hyperinflammatory cytokine storm; and failure of host protective immunity that results in unrestrained vira
Externí odkaz:
https://doaj.org/article/e8dd85cce0b24e16aeb05e045c745304
Autor:
Karine Lélu, Clarisse Dubois, Alexei Evlachev, Morgane Crausaz, Marie Baldazza, Nadine Kehrer, Renée Brandely, Yasmin Schlesinger, Nathalie Silvestre, Jean-Baptiste Marchand, Bérangère Bastien, Stéphane Leung-Theung-Long, Jacqueline Unsinger, Perrine Martin, Geneviève Inchauspé
Publikováno v:
The Journal of Immunology. 209:99-117
Persistence of an immunosuppressive state plays a role in septic patient morbidity and late mortality. Both innate and adaptive pathways are impaired, pointing toward the need for immune interventions targeting both arms of the immune system. We deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c75a95d1caddb33b59d0854c467194c
https://doi.org/10.4049/jimmunol.2101145
https://doi.org/10.4049/jimmunol.2101145
Autor:
Daniel J. Tenney, Anne M. Drewry, Richard S. Hotchkiss, Jacqueline Unsinger, Teresa M. Blood, Andrew H. Walton, Michael Quigley
Publikováno v:
J Leukoc Biol
A defining feature of protracted sepsis is development of immunosuppression that is thought to be a major driving force in the morbidity and mortality associated with the syndrome. The immunosuppression that occurs in sepsis is characterized by profo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323837b1dec80ef4fc46a0aa4d06f2f7
https://doi.org/10.1002/jlb.5hi0720-043r
https://doi.org/10.1002/jlb.5hi0720-043r
Autor:
Ali H. Ellebedy, Daehan J. Yi, Teresa M. Blood, Dale F. Osborne, Anne M. Drewry, Nitin J. Anand, Daniel A. Mannion, Andrew H. Walton, Jane Blood, Jacqueline Unsinger, Isaiah R. Turnbull, Charles C. Caldwell, Lyle L. Moldwawer, Scott C. Brakenridge, Kenneth E. Remy, Philip A. Mudd, Richard S. Hotchkiss, R. Scott Martin, David A. Striker, Monty Mazer, James P. Bosanquet
Publikováno v:
JCI Insight, Vol 5, Iss 17 (2021)
JCI Insight
JCI Insight
COVID-19–associated morbidity and mortality have been attributed to a pathologic host response. Two divergent hypotheses have been proposed: hyperinflammatory cytokine storm; and failure of host protective immunity that results in unrestrained vira
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::731dd661f4222fa7fde9bbbf23f3687b
https://doaj.org/article/e8dd85cce0b24e16aeb05e045c745304
https://doaj.org/article/e8dd85cce0b24e16aeb05e045c745304
Autor:
Peter Buontempo, Cecille D. Browne, Chun-Shiang Chung, Gabriel M. Gutierrez, James Pannucci, Alfred Ayala, Vinayaka Kotraiah, Kenneth E. Remy, Richard S. Hotchkiss, Monty Mazer, Marc Mansour, Timothy W. Phares, Jacqueline Unsinger
Publikováno v:
Shock (Augusta, Ga.)
Sepsis-induced immunosuppression involves both innate and adaptive immunity and is associated with the increased expression of checkpoint inhibitors, such as programmed cell-death protein 1 (PD-1). The expression of PD-1 is associated with poor outco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4bb1b92ba39b8c2bb7eb0af0052366
https://pubmed.ncbi.nlm.nih.gov/33065715
https://pubmed.ncbi.nlm.nih.gov/33065715
Autor:
Jacqueline Unsinger, Grant V. Bochicchio, Tim Eitas, Anja Fuchs, Christopher G. Davis, Yuichiro Shindo, Carey-Ann D. Burnham, Jonathan M. Green, Richard S. Hotchkiss, Michel Morre
Publikováno v:
Journal of Leukocyte Biology. 101:543-554
Patients with protracted sepsis develop impaired immunity, which predisposes them to acquiring secondary infections. One of the most common and lethal secondary infections is Pseudomonas aeruginosa pneumonia. Immunoadjuvant therapy is a promising app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a80039059717e18a3593bfc2567d27a
https://doi.org/10.1189/jlb.4a1215-581r
https://doi.org/10.1189/jlb.4a1215-581r
Autor:
Matthew S. Shotwell, Robin Jeannet, Michel Morre, Thomas Daix, Scott K. Durum, Bruno François, Anne Gregoire, Andrew H. Walton, Guillaume Monneret, Edward R. Sherwood, Richard S. Hotchkiss, Jacqueline Unsinger, Jane Blood, Gail A. Mayo, Teresa M. Blood, Thomas Rimmelé
Publikováno v:
JCI Insight, Vol 3, Iss 5 (2018)
BACKGROUND. A defining pathophysiologic feature of sepsis is profound apoptosis-induced death and depletion of CD4+ and CD8+ T cells. Interleukin-7 (IL-7) is an antiapoptotic common γ-chain cytokine that is essential for lymphocyte proliferation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5556b9b4785445298e860aa025bc324
https://doaj.org/article/8a46c6fc273440f19af24d6a067b24e3
https://doaj.org/article/8a46c6fc273440f19af24d6a067b24e3