Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jacqueline Saenz"'
Autor:
Jacqueline Saenz, Elnaz Khezerlou, Meha Aggarwal, Amina Shaikh, Naga Ganti, Freja Herborg, Ping-Yue Pan
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Missense mutations of PARK20/SYNJ1 (synaptojanin1/Synj1) were found in complex forms of familial Parkinsonism. However, the Synj1-regulated molecular and cellular changes associated with dopaminergic dysfunction remain unknown. We now report
Externí odkaz:
https://doaj.org/article/2d552f412571417fb6cc6fb18eb2aa83
Publikováno v:
STAR Protocols, Vol 5, Iss 4, Pp 103358- (2024)
Summary: Surface availability of the dopamine (DA) transporter (DAT) critically influences DA transmission. Here, we present a protocol that describes the preparation of mouse ventral midbrain neurons, the expression of a new optical sensor, DAT-pHlu
Externí odkaz:
https://doaj.org/article/963453784d444760acddee61f96e93b1
Autor:
Jennifer I. Mejaes, Jacqueline Saenz, Chris O’Brien, Carina M. Pizzano, Ping-Yue Pan, David J. Barker
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 18 (2024)
The synaptojanin-1 (SYNJ1) gene is known to be important for dopamine-related disorders. Recent evidence has demonstrated that Synj1 deficient mice (Synj1+/−) have impairments in dopaminergic synaptic vesicular recycling. However, less is known abo
Externí odkaz:
https://doaj.org/article/ca2696e408a74e8686d9fde09b2a9ae8
Autor:
Jacqueline Saenz, Oscar Yao, Elnaz Khezerlou, Meha Aggarwal, Xiaofeng Zhou, David J. Barker, Emanuel DiCicco-Bloom, Ping-Yue Pan
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105782- (2023)
Summary: Cocaine acts by inhibiting plasma membrane dopamine transporter (DAT) function and altering its surface expression. The precise manner and mechanism by which cocaine regulates DAT trafficking, especially at neuronal processes, are poorly und
Externí odkaz:
https://doaj.org/article/15c8027ce0134503a40e41d24439786c
Autor:
Jacqueline Saenz, Oscar Yao, Meha Aggarwal, Xiaofeng Zhou, David J. Barker, Emanuel DiCicco-Bloom, Ping-Yue Pan
The dopamine transporter (DAT) mediated DA reuptake is a major molecular mechanism for termination of dopaminergic signaling in the brain. Psychoactive substances such as cocaine act by inhibition of plasma membrane DAT function as well as by alterin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e64d9f6e94ea118dd7aafe74f7f44f4b
https://doi.org/10.1101/2022.10.12.511970
https://doi.org/10.1101/2022.10.12.511970
Autor:
Cindy S. Malone, Jacqueline Saenz, William Van Trigt, Ruslan L Nuryyev, Randy W. Cohen, Jessica Ochoa, Menaga Shanmugam, Andrew P St. Julian, Celavie Biosciences Llc, Oxnard, Ca Usa, Toni L. Uhlendorf, Alex Kopyov, Sabrina K Uppal, Oleg V. Kopyov
Publikováno v:
AIMS Medical Science. 8:252-268
It has been established that the CA3 region of the hippocampus is involved in consolidating short-term memory to long-term memory and aids in spatial navigation retention. Seizures and many neurologic diseases induce damage to that region of the hipp
Autor:
Jing Wang, Jacqueline Saenz, Dongming Cai, Ping Yue Pan, Patricia Sheehan, Qian Wang, Yuanxi Zhang, Zhenyu Yue, Xianting Li, Xinyu Zhu, Insup Choi, Li Zhu, Justin Zhu, Farida El Gaamouch
Publikováno v:
Hum Mol Genet
Synaptojanin1 (synj1) is a phosphoinositide phosphatase with dual SAC1 and 5′-phosphatase enzymatic activities in regulating phospholipid signaling. The brain-enriched isoform has been shown to participate in synaptic vesicle (SV) recycling. More r